Weight Loss and CLOCK 3111T/C Polymorphism

Launched by HACETTEPE UNIVERSITY · Feb 20, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a specific gene variant called CLOCK 3111T/C and how it may relate to weight, eating habits, sleep patterns, and health in people who are overweight or obese. The researchers want to find out if people with this gene variant have different eating habits, sleep schedules, or responses to weight loss diets compared to those with normal body weight. To do this, they will gather information through questionnaires, measure participants' body size and weight, and analyze blood samples to look for the gene variant and certain hormones related to metabolism.

To join the study, participants need to be between 20 and 50 years old. Those who are overweight should have a body mass index (BMI) between 25 and 40, while individuals with normal weight should have a BMI between 18.5 and 24.9. The trial is currently recruiting participants, and those who qualify will follow a weight loss diet for three months while providing information about their eating and activity levels. This study could help us understand how genetics may influence weight loss and overall health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Be in the 20-50 age range
• • BMI in the range of 25-40 kg/m2 for the study group
• • BMI of 18.5-24.9 kg/m2 for the control group
• Exclusion Criteria:
• • Those with type 1 diabetes
• • Those with Type 2 diabetes who take insulin therapy or use oral diabetes medication
• • Those who use drugs for weight loss
• • Those with unstable cardiovascular disease
• • Those with kidney or liver failure
• • Presence of diagnosed malabsorption (celiac disease, Crohn's, ulcerative colitis)
• • Those who have undergone bariatric surgery
• • Those who are pregnant or breastfeeding
• • Menopausal women
• • Those who use corticosteroids
• • Those with severe endocrine disorders (hypothyroidism, hyperthyroidism, hypopituitarism)
• • Those with psychiatric or neurological disease
• • Weight change of \>5% in the last 6 months
• • Those with malignant tumors
• • Those with eating disorders
• • Shift workers
• • Relatives
• • People from different ethnic backgrounds