Analgesia-First Sedation in Trauma Patients

Launched by MEMORIALCARE HEALTH SYSTEM · Feb 28, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Analgesia-First Sedation in Trauma Patients," is exploring the best way to manage pain and sedation for patients who have experienced trauma and need help breathing with a machine called a ventilator. Traditionally, doctors give patients a steady drip of sedatives and pain relief, waking them up once a day to assess their brain function. However, this study is looking at an alternative method where patients receive pain relief but only get sedatives when absolutely necessary. This approach has not been tested specifically in trauma patients before.

To participate in this trial, individuals must be at least 18 years old, be on a ventilator for at least 48 hours, and have started receiving continuous sedatives and pain medications from the ICU team. Some people may not be eligible, such as those who have had a cardiac arrest, have significant long-term neurological issues, or have a history of substance abuse. Participants in the trial can expect to receive either the standard sedation method or the new approach, helping researchers understand which is more effective for managing pain and sedation in trauma patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ≥ 18 years of age
• • 2. Mechanically ventilated with an expected duration of MV ≥ 48h
• • 3. Initiated continuous sedative/analgesic infusions by the ICU team
• • 4. Patient is a candidate for MV weaning
• Exclusion Criteria:
• • 1. Admission after resuscitation from cardiac arrest
• • 2. Significant neurological deficit due to a chronic disorder
• • 3. History of alcohol dependence and/or other illicit drug abuse
• • 4. Prior administration of continuous sedative/analgesic from a transferring institution
• • 5. Patient receiving neuromuscular blocking agents
• • 6. Allergy to midazolam, lorazepam, and/or propofol