The Microbiome in (Non-) Obese Pregnancy and Pregnancy Outcomes

Launched by ERASMUS MEDICAL CENTER · Feb 22, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how obesity in pregnant women might affect their health and the health of their babies. Researchers are particularly interested in understanding the role of gut bacteria, which are tiny organisms living in our intestines, in these health outcomes. By investigating this, the study aims to find ways to prevent complications during pregnancy and improve long-term health for both mothers and their children.

Women who are interested in participating should be between 18 and 45 years old, planning to become pregnant or currently less than 13 weeks pregnant, and have a body mass index (BMI) of either over 30 (considered obese) or between 18-25 (considered normal weight). Participants will need to understand Dutch and be willing to give their consent to join. Those who smoke, have certain health conditions, or are further along in their pregnancy won’t be eligible. If you join, you can expect to contribute to important research that could help improve pregnancy outcomes for many women in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Participation in Predict study
• • Preconceptional women who wish to become pregnant or pregnancy \<13 weeks of gestational age.
• • BMI \> 30 kg/m2 or 18-25 kg/m2
• • Understanding of Dutch in speaking and reading
• • Willingness to give written informed consent
• Exclusion Criteria:
• • Age \< 18 years and \> 45 years.
• • ≥13 weeks of gestational age
• • Multiple pregnancy
• • Smoking
• • Gastro-intestinal diseases, heart diseases, liver, pancreas and kidney diseases.
• • Use of antibiotics \< 2 weeks before sampling
• • Pre-existent diabetes mellitus