A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
Launched by JANSSEN RESEARCH & DEVELOPMENT, LLC · Feb 23, 2023
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a medication called milvexian to see if it can help reduce the risk of serious heart problems in patients who have recently experienced an acute coronary syndrome (ACS), which includes conditions like heart attacks. The goal is to find out if milvexian works better than a placebo (a harmless pill with no active ingredients) when given alongside standard heart care treatments.
To be eligible for this study, participants should be aged 65 or older and must have had a recent heart issue that meets specific criteria, such as elevated heart-related markers in the blood. They should also have at least two additional risk factors for heart disease, such as having diabetes or a history of heart problems. If you or a loved one is interested in participating, you'll receive regular check-ups and monitoring throughout the trial. It's important to note that women who can become pregnant will need to take precautions, as pregnancy is not allowed during the study. Overall, this trial aims to find new ways to protect heart health after serious events.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction \[STEMI\], non-STEMI, or unstable angina \[UA\]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB \[CK-MB\]) above the upper limit of normal as determined by the local laboratory
- • Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention \[PCI\] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (\>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- • All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- • A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
- Exclusion Criteria:
- • MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- • Planned CABG or staged PCI after randomization
- • Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- • Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
About Janssen Research & Development, Llc
Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson, is a leading pharmaceutical company dedicated to advancing innovative therapies in multiple therapeutic areas, including oncology, immunology, neuroscience, infectious diseases, and cardiovascular health. With a strong commitment to scientific excellence and patient-centered research, Janssen leverages cutting-edge technology and collaborative partnerships to drive the development of transformative treatments. The company is focused on addressing unmet medical needs through rigorous clinical trials and a robust pipeline, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Fort Worth, Texas, United States
Winnipeg, Manitoba, Canada
Patna, , India
Nishinomiya Shi, , Japan
Barcelona, , Spain
Shinagawa, , Japan
Fremont, California, United States
Birmingham, Alabama, United States
Mobile, Alabama, United States
Phoenix, Arizona, United States
Scottsdale, Arizona, United States
Tucson, Arizona, United States
La Jolla, California, United States
Munster, Indiana, United States
Saginaw, Michigan, United States
Bridgewater, New Jersey, United States
Sherman, Texas, United States
Austria, , Austria
Wiener Neustadt, , Austria
Brussels, , Belgium
Curitiba, , Brazil
Passo Fundo, , Brazil
Porto Alegre, , Brazil
Ribeirao Preto, , Brazil
Salvador, , Brazil
Vitória, , Brazil
Newmarket, Ontario, Canada
Beijing, , China
Hangzhou, , China
Nanjing, , China
Suzhou, , China
Tianjin, , China
Wuhan, , China
Xi'an, Shaanxi, China
Krapinske Toplice, , Croatia
Ostrava, , Czechia
Prague, , Czechia
Frankfurt, , Germany
Luedenscheid, , Germany
Magdeburg, , Germany
Mainz, , Germany
Zalaegerszeg, , Hungary
Bangalore, , India
Belgaum, , India
Kolkata, , India
Mumbai, , India
Milano, , Italy
Roma, , Italy
Seoul, , Korea, Republic Of
Athens, , Greece
Seoul, , Korea, Republic Of
Yangsan Si, , Korea, Republic Of
Kaunas, , Lithuania
Panevezys, , Lithuania
Kota Bharu, , Malaysia
Kota Kinabalu, , Malaysia
Guadalajara, , Mexico
Xalapa, , Mexico
Almelo, , Netherlands
Den Haag, , Netherlands
Goes, , Netherlands
Gouda, , Netherlands
Muntinlupa, , Philippines
Pasig City, , Philippines
Ostrowiec Swietokrzyski, , Poland
Adana, , Turkey
Antalya, , Turkey
Malatya, , Turkey
Samsun, , Turkey
Blackpool, , United Kingdom
Ho Chi Minh, , Vietnam
Saint Louis, Missouri, United States
Cordoba, , Argentina
Yichang, , China
Yinchuan, , China
Mainz, , Germany
Heraklion, , Greece
Hanoi, , Vietnam
Bialystok, , Poland
Houston, Texas, United States
Cordoba, , Argentina
Sao Bernardo Do Campo, , Brazil
Kingston Upon Thames, , United Kingdom
Ho Chi Minh, , Vietnam
São Paulo, , Brazil
Vitória, , Brazil
Changchun, , China
Bonn Beuel, , Germany
Leverkusen, , Germany
Brasov, , Romania
Taunton, , United Kingdom
Jacksonville, Florida, United States
Cartersville, Georgia, United States
El Paso, Texas, United States
Votuporanga, , Brazil
Plovdiv, , Bulgaria
Creteil, , France
Nice Cedex 1, , France
Rouen, , France
Bielefeld, , Germany
Szeged, , Hungary
Bologna, , Italy
Centurion, , South Africa
Taoyuan County, , Taiwan
Stevenage, , United Kingdom
Bangor, Maine, United States
Hangzhou, Zhejiang, China
Xuzhou, , China
Yanji, , China
Kolin, , Czechia
Auckland, , New Zealand
Otahuhu, , New Zealand
Rotorua, , New Zealand
Springfield, Ohio, United States
Pembroke Pines, Florida, United States
Cordoba, , Argentina
Peterborough, , United Kingdom
Cordoba, , Argentina
Terrebonne, Quebec, Canada
Budapest, , Hungary
Vila Real, , Portugal
Niska Banja, , Serbia
Redding, California, United States
Amarillo, Texas, United States
Manila, , Philippines
Bournemouth, , United Kingdom
Mobile, Alabama, United States
Tampa, Florida, United States
Nashville, Tennessee, United States
Recife, , Brazil
Dongguan, , China
Wenzhou, , China
Guiyang, , China
Hiratsuka Shi, , Japan
Toyama Shi, , Japan
Tiel, , Netherlands
Englewood, New Jersey, United States
Praha 2, , Czechia
Valhalla, New York, United States
Concord, , Australia
Quebec, , Canada
Zhanjiang, , China
Rijeka, , Croatia
Szolnok, , Hungary
Tokyo, , Japan
Mazatlan, , Mexico
Nieuwegein, , Netherlands
Tetovo, , North Macedonia
Cavite, , Philippines
Mandaluyong, , Philippines
Olsztyn, , Poland
Coimbra, , Portugal
Santa Maria Da Feira, , Portugal
Hanoi, , Vietnam
Braga, , Portugal
Gurnee, Illinois, United States
Baltimore, Maryland, United States
Tomball, Texas, United States
Wien, , Austria
Cambridge, Ontario, Canada
Temuco, , Chile
Targu Mures, , Romania
Singapore, , Singapore
Somerset West, , South Africa
Hanoi, , Vietnam
Ho Chi Minh, , Vietnam
Chongqing, , China
Taipei, , Taiwan
Springfield, Missouri, United States
Tsu, , Japan
Aguascalientes, , Mexico
Prague, , Czechia
Brasov, , Romania
Bursa, , Turkey
Plymouth, , United Kingdom
Sao Paulo, , Brazil
Vandoeuvre Les Nancy Cedex, , France
Bakersfield, California, United States
Santa Monica, California, United States
Orange, Florida, United States
Sarasota, Florida, United States
Sarasota, Florida, United States
Atlanta, Georgia, United States
Sofia, , Bulgaria
Stara Zagora, , Bulgaria
Calgary, Alberta, Canada
Moncton, New Brunswick, Canada
Alexandroupolis, , Greece
Athens, , Greece
Chennai, , India
Hastings, , New Zealand
Durban, , South Africa
Madrid, , Spain
Somerset West, , South Africa
Barcelona, , Spain
Swansea, , United Kingdom
Chambersburg, Pennsylvania, United States
New Taipei, , Taiwan
Sao Paulo, , Brazil
Bonn, , Germany
Aveiro, , Portugal
Madrid, , Spain
Ho Chi Minh, , Vietnam
Nijmegen, , Netherlands
Jacksonville, Florida, United States
Peterborough, Ontario, Canada
Elkhart, Indiana, United States
Philadelphia, Pennsylvania, United States
Cordoba, , Argentina
Jihlava, , Czechia
Poitiers, , France
Bitburg, , Germany
Littleton, Colorado, United States
Wroclaw, , Poland
Covilha, , Portugal
Bucuresti, , Romania
Cape Town, , South Africa
Mossel Bay, , South Africa
Kasuga Shi, , Japan
Gijon, , Spain
London, , United Kingdom
Hyderbad, , India
Izmir, , Turkey
Moenchengladbach, , Germany
Dorchester, , United Kingdom
Shiwa Gun, , Japan
Kuching, , Malaysia
Bucuresti, , Romania
Yilan County, , Taiwan
London, , United Kingdom
Florencio Varela, , Argentina
Camperdown, , Australia
Hamburg, , Germany
Cheongju Si, , Korea, Republic Of
Culiacan, , Mexico
Madrid, , Spain
Springfield, Illinois, United States
Olsztyn, , Poland
Afula, , Israel
Haifa, , Israel
Pavia, , Italy
Hradec Kralove, , Czechia
Gainesville, Georgia, United States
Redhill, , United Kingdom
New York, New York, United States
Natal, , Brazil
Miri, , Malaysia
Birmingham, , United Kingdom
Hanoi, , Vietnam
Dubrovnik, , Croatia
Haifa, , Israel
La Spezia, , Italy
San Luis Potosí, , Mexico
Madrid, , Spain
Brasilia, , Brazil
Remscheid, , Germany
Helmond, , Netherlands
Venlo, , Netherlands
Ramat Gan, , Israel
Mobile, Alabama, United States
San Diego, California, United States
Santa Rosa, California, United States
Saint Paul, Minnesota, United States
Bern, , Switzerland
Lenoir, North Carolina, United States
Kansas City, Missouri, United States
Birtinya, , Australia
Minot, North Dakota, United States
Curitiba, , Brazil
Curitiba, , Brazil
Kyle, Texas, United States
Brno, , Czechia
Athens, , Greece
Athens, , Greece
Milano, , Italy
Guiyang, , China
Saga, , Japan
Shinagawa, , Japan
Huizhou, , China
Tokyo, , Japan
Harderwijk, , Netherlands
Ureshino Shi, , Japan
Kuala Lumpur, , Malaysia
Leiderdorp, , Netherlands
Krakow, , Poland
Leeds, , United Kingdom
New Taipei, , Taiwan
Ciudad Autonoma Buenos Aires, , Argentina
Tainan, , Taiwan
Nagpur, , India
Taipei, , Taiwan
Alkmaar, , Netherlands
Bath, , United Kingdom
Wuxi, , China
Selayang, , Malaysia
Sao Paulo, , Brazil
Linfen, , China
Sofia, , Bulgaria
Amersfoort, , Netherlands
Osaka Shi, , Japan
Nanjing, , China
Basel, , Switzerland
Seberang Jaya, , Malaysia
Vilnius, , Lithuania
Zajecar, , Serbia
Birmingham, Alabama, United States
Boca Raton, Florida, United States
Las Vegas, Nevada, United States
Nashville, Tennessee, United States
New York, New York, United States
Everett, Washington, United States
Porto Alegre, , Brazil
Zalaegerszeg, , Hungary
Quebec, , Canada
Ashkelon, , Israel
Seoul, , Korea, Republic Of
Beijing, , China
Kota Bahru, , Malaysia
Bronx, New York, United States
Huntsville, Alabama, United States
Newport Beach, California, United States
West Bromwich, , United Kingdom
Gainesville, Georgia, United States
Chicago, Illinois, United States
Fort Wayne, Indiana, United States
Bethesda, Maryland, United States
Hazel Crest, Illinois, United States
Salisbury, Maryland, United States
Saginaw, Michigan, United States
Tupelo, Mississippi, United States
Kansas City, Missouri, United States
Bronx, New York, United States
Lincoln, Nebraska, United States
Chapel Hill, North Carolina, United States
Kettering, Ohio, United States
Jackson, Tennessee, United States
Rock Hill, South Carolina, United States
Nashville, Tennessee, United States
Amarillo, Texas, United States
El Paso, Texas, United States
Leesburg, Virginia, United States
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Tacoma, Washington, United States
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Junin, , Argentina
Quilmes, , Argentina
Rosario, , Argentina
Cordoba, , Argentina
Rosario, , Argentina
Salta, , Argentina
Salta, , Argentina
San Miguel De Tucuman, , Argentina
San Nicolas, , Argentina
Santa Fe, , Argentina
Santa Fe, , Argentina
Villa Maria, , Argentina
Santa Fe, , Argentina
Ballarat, , Australia
Adelaide, , Australia
Cairns, , Australia
Innsbruck, , Austria
Clayton, , Australia
Linz, , Austria
Graz, , Austria
Vienna, , Austria
Wien, , Austria
Brugge, , Belgium
Brasschaat, , Belgium
Bruxelles, , Belgium
Genk, , Belgium
Liege, , Belgium
Bruxelles, , Belgium
Liège, , Belgium
Mechelen, , Belgium
Mol, , Belgium
Roeselare, , Belgium
Belo Horizonte, , Brazil
Belo Horizonte, , Brazil
Brasília, , Brazil
Campinas, , Brazil
Curitiba, , Brazil
Criciúma, , Brazil
Marilia, , Brazil
Natal, , Brazil
Porto Alegre, , Brazil
Salvador, , Brazil
Santo André, , Brazil
Goiania, , Brazil
Sao Jose Do Rio Preto, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
São Jose Do Rio Preto, , Brazil
São José, , Brazil
Uberaba, , Brazil
Burgas, , Bulgaria
Gabrovo, , Bulgaria
Panagyurishte, , Bulgaria
Pernik, , Bulgaria
Pleven, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Edmonton, Alberta, Canada
Sao Paulo, , Brazil
Vancouver, British Columbia, Canada
Hamilton, Ontario, Canada
Windsor, Ontario, Canada
Montreal, Quebec, Canada
London, Ontario, Canada
St Jean Sur Richelieu, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Montreal, Quebec, Canada
Talcahuano, , Chile
Quebec, , Canada
Baotou, , China
Beijing, , China
Beijing, , China
Beijing, , China
Beijing, , China
Changsha, , China
Changzhou, , China
Beijing, , China
Chengdu, , China
Fuzhou, , China
Chengdu, , China
Hangzhou, , China
Guiyang, , China
Jinan, , China
Jining, , China
Lanzhou, , China
Nanchang, , China
Nanjing, , China
Shenzhen, , China
Su Zhou, , China
Wenzhou, , China
Wenzhou, , China
Wulumuqi, , China
Hangzhou, , China
Zunyi, , China
Cakovec, , Croatia
Zabok, , Croatia
Zagreb, , Croatia
Wuhan, , China
Thessaloniki, , Greece
Jerusalem, , Israel
Brno, , Czechia
Ceske Budejovice, , Czechia
Liberec, , Czechia
Plzen, , Czechia
Slavonski Brod, , Croatia
Praha 2, , Czechia
Prague, , Czechia
Frederiksberg, , Denmark
Copenhagen S, , Denmark
Holbæk, , Denmark
Hvidovre, , Denmark
Koge, , Denmark
Slagelse, , Denmark
ålborg, , Denmark
Tallinn, , Estonia
Chambray Les Tours, , France
Corbeil Essonnes Cedex, , France
Brno, , Czechia
San Martin, , Argentina
La Tronche, , France
Le Coudray, , France
Lille Cedex, , France
Lyon, , France
Nîmes Cedex 9, , France
Paris, , France
Rouen Cedex, , France
Berlin, , Germany
Berlin, , Germany
Montauban, , France
Coburg, , Germany
Dortmund, , Germany
Duesseldorf, , Germany
Greifswald, , Germany
Berlin, , Germany
Neuwied, , Germany
Rostock, , Germany
Worms, , Germany
Athens Attica, , Greece
Athens, , Greece
Ioannina, , Greece
Hamburg, , Germany
Larissa, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Patra, , Greece
Budapest, , Hungary
Debrecen, , Hungary
Gyula, , Hungary
Miskolc, , Hungary
Pecs, , Hungary
Szekszárd, , Hungary
Amritsar, , India
Bangalore, , India
Delhi, , India
Faridabad, , India
Hyderabad, , India
Kolkata, , India
Kolkata, , India
Mangalore, , India
Gyor, , Hungary
Mysore, , India
Nagpur, , India
Nagpur, , India
Pune, , India
Ulhasnagar, , India
Ashdod, , Israel
Haifa, , Israel
Holon, , Israel
Jerusalem, , Israel
Jerusalem, , Israel
Kfar Sava, , Israel
Beersheba, , Israel
Rechovot, , Israel
Tiberias, , Israel
Safed, , Israel
Milano, , Italy
Pisa, , Italy
Roma, , Italy
Sassari, , Italy
Seriate, , Italy
Treviso, , Italy
Chiba, , Japan
Fukuoka Shi, , Japan
Himeji Shi, , Japan
Treviglio, , Italy
Hiroshima, , Japan
Isehara, , Japan
Kitakyushu Shi, , Japan
Koga, , Japan
Kure Shi, , Japan
Matsumoto Shi, , Japan
Meguro Ku, , Japan
Minato Ku, , Japan
Miyazaki Shi, , Japan
Okayama Shi, , Japan
Sendai, , Japan
Shinjuku Ku, , Japan
Suita Shi, , Japan
Saitama, , Japan
Tokyo, , Japan
Tokyo, , Japan
Tokyo, , Japan
Ube, , Japan
Tokyo, , Japan
Busan, , Korea, Republic Of
Urayasu Shi, , Japan
Busan, , Korea, Republic Of
Chuncheon, , Korea, Republic Of
Gangseo Gu, , Korea, Republic Of
Gwangju, , Korea, Republic Of
Incheon, , Korea, Republic Of
Busan, , Korea, Republic Of
Sejong Si, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Wonju, , Korea, Republic Of
Daugavpils, , Latvia
Liepaja, , Latvia
Kaunas, , Lithuania
Klaipeda, , Lithuania
Riga, , Latvia
Jalapa, , Mexico
San Luis Potosí, , Mexico
Tijuana, , Mexico
Amsterdam, , Netherlands
Ede, , Netherlands
Eindhoven, , Netherlands
Siauliai, , Lithuania
Roermond, , Netherlands
Rotterdam, , Netherlands
Veldhoven, , Netherlands
Zutphen, , Netherlands
Dunedin, , New Zealand
Tauranga, , New Zealand
Enschede, , Netherlands
Quezon, , Philippines
Dasmarinas, , Philippines
San Juan, , Philippines
Lublin, , Poland
Lodz, , Poland
Oswiecim, , Poland
Torun, , Poland
Warszawa, , Poland
Naleczow, , Poland
Wroclaw, , Poland
Wałbrzych, , Poland
Wroclaw, , Poland
Zabrze, , Poland
Coimbra, , Portugal
Guimarães, , Portugal
Lisbon, , Portugal
Baia Mare, , Romania
Bucuresti, , Romania
Lisboa, , Portugal
Cluj Napoca, , Romania
Pitesti, , Romania
Cluj Napoca, , Romania
Timisoara, , Romania
Timisoara, , Romania
Targu Mures, , Romania
Belgrade, , Serbia
Kragujevac, , Serbia
Uzice, , Serbia
Bardejov, , Slovakia
Singapore, , Singapore
Kosice, , Slovakia
Kosice, , Slovakia
Bratislava, , Slovakia
Lucenec, , Slovakia
Košice, , Slovakia
Presov, , Slovakia
Moldava Nad Bodvou, , Slovakia
Zilina, , Slovakia
Svidnik, , Slovakia
Johannesburg, , South Africa
Bloemfontein, , South Africa
Alicante, , Spain
Manchester, , United Kingdom
Madrid, , Spain
Pamplona, , Spain
Cary, North Carolina, United States
Ciudad Autonoma De Buenos Aires, , Argentina
Budapest, , Hungary
Zuerich, , Switzerland
Kaohsiung, , Taiwan
Ankara, , Turkey
Pathum Wan, , Thailand
Lublin, , Poland
Lleida, , Spain
Ankara, , Turkey
Basingstoke, , United Kingdom
Gunma, , Japan
Northridge, California, United States
Louisville, Kentucky, United States
Istanbul, , Turkey
Falls Church, Virginia, United States
Porto Alegre, , Brazil
Takamatsu, , Japan
Maastricht, , Netherlands
Brandenburg An Der Havel, , Germany
Toledo, Ohio, United States
La Plata, , Argentina
Mar Del Plata, , Argentina
Rosario, , Argentina
Salta, , Argentina
Elizabeth Vale, , Australia
Sanford, North Carolina, United States
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Wollongong, , Australia
Porto Alegre, , Brazil
Woodville South, , Australia
Recife, , Brazil
Tartu, , Estonia
Recife, , Brazil
Limoges, , France
Paris, , France
Pessac, , France
Tradate, , Italy
Nagoya Shi, , Japan
Dijon Cedex, , France
Tsukuba City, , Japan
Daegu, , Korea, Republic Of
Riga, , Latvia
Davao City, Davao Del Sur, , Philippines
Bydgoszcz, , Poland
Elbląg, , Poland
Krakow, , Poland
Ilocos Sur, , Philippines
Warszawa, , Poland
Iloilo City, , Philippines
Leiria, , Portugal
Wroclaw, , Poland
Almada, , Portugal
Vila Nova De Gaia, , Portugal
Bucharest, , Romania
Bucuresti, , Romania
Aveiro, , Portugal
Cluj Napoca, , Romania
Belgrade, , Serbia
Ha Noi, , Vietnam
Paris, , France
Belgrade, , Serbia
Toulouse Cedex 9, , France
Berlin, , Germany
Bucuresti, , Romania
Brasilia, , Brazil
Sopot, , Poland
Campina Grande Do Sul, , Brazil
Nagoya Shi, , Japan
Daejeon, , Korea, Republic Of
Akron, Ohio, United States
Guimaraes, , Portugal
Barcelona, , Spain
Kaposvar, , Hungary
Campinas, , Brazil
Barcelona, , Spain
Christchurch, , New Zealand
Manises, , Spain
Pomona, New Jersey, United States
Saitama Shi, , Japan
Angers, , France
Taipei, , Taiwan
Taipei, , Taiwan
Gyeonggi Do, , Korea, Republic Of
Kaohsiung, , Taiwan
Zaragoza, , Spain
Bergamo, , Italy
Hirosaki, , Japan
Amagasaki Shi, , Japan
Thessaloniki, , Greece
Salvador, , Brazil
Nagpur, , India
Jacksonville, Florida, United States
Duluth, Minnesota, United States
Singapore, , Singapore
Martin, , Slovakia
Winchester, Virginia, United States
Stockton, California, United States
Katowice, , Poland
El Paso, Texas, United States
Krakow, , Poland
Ankara, , Turkey
Petah Tikva, , Israel
Danbury, Connecticut, United States
Stamford, Connecticut, United States
Fort Lauderdale, Florida, United States
Angers, , France
Poitiers, , France
Little Rock, Arkansas, United States
Southport, , Australia
Levis, Quebec, Canada
Palo Alto, California, United States
San Diego, California, United States
Trumbull, Connecticut, United States
Gilbert, Arizona, United States
Richmond, Indiana, United States
Shreveport, Louisiana, United States
Slidell, Louisiana, United States
Haverhill, Massachusetts, United States
Bay City, Michigan, United States
Grand Blanc, Michigan, United States
Peoria, Illinois, United States
Poughkeepsie, New York, United States
Caba, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Adelaide, South Australia, Australia
Herston, , Australia
Braunau Am Inn, , Austria
Edegem, , Belgium
Gent, , Belgium
Hasselt, , Belgium
Rosario, , Argentina
Belo Horizonte, , Brazil
Curitiba, , Brazil
Pelotas, , Brazil
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
Haskovo, , Bulgaria
São Paulo, , Brazil
Puerto Varas, , Chile
Santiago, , Chile
Dongguan, , China
Guangzhou, , China
Hefei, , China
Oakville, Ontario, Canada
Ningbo, , China
Ostrava Poruba, , Czechia
Tianjin, , China
Pardubice, , Czechia
Praha 4, , Czechia
Praha 10, , Czechia
Viborg, , Denmark
Montpellier, , France
Vandoeuvre Les Nancy Cedex, , France
Versailles Cedex, , France
Bad Krozingen, , Germany
Bremen, , Germany
Dresden, , Germany
Erfurt, , Germany
Tübingen, , Germany
New Delhi, , India
Surat, , India
Mestre, , Italy
Milano, , Italy
Aichi, , Japan
Ishikawa, , Japan
Kisarazu Shi, , Japan
Herlev, , Denmark
Matsudo Shi, , Japan
Nagano Shi, , Japan
Osaka, , Japan
Tokyo, , Japan
Yokohama, , Japan
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Monterrey, , Mexico
Kumamoto Shi, , Japan
Kurashiki, , Japan
Torreon, , Mexico
Nijmegen, , Netherlands
New Plymouth, , New Zealand
Baguio City, , Philippines
Quezon City, , Philippines
Auckland, , New Zealand
Nitra, , Slovakia
Craiova, , Romania
Tg. Mures, , Romania
Worcester, , South Africa
El Palmar, , Spain
Valencia, , Spain
Taipei, , Taiwan
Urbana, Illinois, United States
Jackson, Mississippi, United States
Raleigh, North Carolina, United States
Harrisburg, Pennsylvania, United States
Wynnewood, Pennsylvania, United States
Feldkirch, , Austria
Santiago De Compostela, , Spain
Criciúma, , Brazil
Porto Alegre, , Brazil
Chengdu, , China
Sao Paulo, , Brazil
Jinan, , China
Mulhouse Cedex, , France
Fukui Shi, , Japan
Fukuoka, , Japan
Gifu, , Japan
Wakayama, , Japan
Seoul, , Korea, Republic Of
Hampstead, , United Kingdom
Harefield, , United Kingdom
San Diego, California, United States
Ann Arbor, Michigan, United States
Lansing, Michigan, United States
Sherman, Texas, United States
Naples, Florida, United States
Wellington, Florida, United States
Vancouver, British Columbia, Canada
Trois Rivières, Quebec, Canada
Salvador, , Brazil
Sao Jose Do Rio Preto, , Brazil
Tianjin, , China
Tianjin, , China
Trinec, , Czechia
Budapest, , Hungary
Kecskemet, , Hungary
Pune, , India
Birmingham, Alabama, United States
Sarasota, Florida, United States
Turnhout, , Belgium
Belo Horizonte, , Brazil
Ceske Budejovice, , Czechia
Pardubice, , Czechia
Herning, , Denmark
Whangarei, , New Zealand
Przemysl, , Poland
Nove Zamky, , Slovakia
Wuhan, , China
Phoenix, Arizona, United States
Coeur D'alene, Idaho, United States
Omaha, Nebraska, United States
Somerset, New Jersey, United States
Palo Alto, California, United States
Muncie, Indiana, United States
Cordoba, , Argentina
Vina Del Mar, , Chile
Downers Grove, Illinois, United States
Mainz, , Germany
Sta Rosa, , Philippines
Bialystok, , Poland
Bahia Blanca, , Argentina
Elblag, , Poland
Krakow, , Poland
Lublin, , Poland
Bydgoszcz, , Poland
Poznan, , Poland
Sopot, , Poland
Wigan, , United Kingdom
Wroclaw, , Poland
Athens, , Greece
Wroclaw, , Poland
Kumamoto City, , Japan
Wroclaw, , Poland
Belgrade, , Serbia
Cebu, , Philippines
Olsztyn, , Poland
Vitoria, , Brazil
Davao, , Philippines
Temuco, , Chile
Marikina City, , Philippines
Aahus N, , Denmark
Chieti, , Italy
Leicester, , United Kingdom
Lincoln, , United Kingdom
Pulau Pinang, , Malaysia
Szombathely, , Hungary
Oklahoma City, Oklahoma, United States
Tatuí, , Brazil
Changzhou, , China
Hangzhou, , China
Lipa City, , Philippines
Kielce, , Poland
Smederevo, , Serbia
Istanbul, , Turkey
Kyoto Shi, , Japan
Kuala Lumpur, , Malaysia
Queretaro, , Mexico
Bad Friedrichshall, , Germany
Iloilo, , Philippines
Mersin, , Turkey
Bristol, , United Kingdom
Fort Lauderdale, Florida, United States
Caen Cedex, , France
Chattanooga, Tennessee, United States
Houston, Texas, United States
Poços De Caldas, , Brazil
Pleven, , Bulgaria
Milano, , Italy
Dudley, , United Kingdom
Thomasville, Georgia, United States
Miami, Florida, United States
New Orleans, Louisiana, United States
West Monroe, Louisiana, United States
Rouen Cedex, , France
Trinity, Florida, United States
Sagamihara, , Japan
Tokyo, , Japan
Bruxelles, , Belgium
Bruxelles, , Belgium
Zhongshan, , China
Bonheiden, , Belgium
Sendai, , Japan
Bytom, , Poland
Tokyo, , Japan
Heerlen, , Netherlands
Torun, , Poland
Lugano, Ticino, Switzerland
Greensboro, North Carolina, United States
Walbrzych, , Poland
Vila Nova De Gaia, , Portugal
Sremska Kamenica, , Serbia
Newport News, Virginia, United States
Erie, Pennsylvania, United States
Bytom, , Poland
Londonderry, , United Kingdom
Bartlesville, Oklahoma, United States
North Miami Beach, Florida, United States
Alexander City, Alabama, United States
Svendborg, , Denmark
La Tronche, , France
Goyang Si, , Korea, Republic Of
Banska Bystrica, , Slovakia
Nis, , Serbia
Angeles, , Philippines
Singapore, , Singapore
Madrid, , Spain
Loxahatchee Groves, Florida, United States
Ciudad Autonoma Buenos Aires, , Argentina
Jerusalem, , Israel
Naharya, , Israel
Parma, , Italy
Nanjing, , China
Hamburg, , Germany
Sremska Kamenica, , Serbia
Chiangmai, , Thailand
Zhengzhou, , China
Taipei, , Taiwan
Kanazawa Shi, , Japan
San Diego, California, United States
Alexandria, Louisiana, United States
Flint, Michigan, United States
Santo Andre, , Brazil
Zhongshan, , China
Szekszárd, , Hungary
Alessandria, , Italy
Bergamo, , Italy
Roma, , Italy
Tsuchiura City, , Japan
Seoul, , Korea, Republic Of
Eskisehir, , Turkey
Birmingham, , United Kingdom
Palos Hills, Illinois, United States
Rishon Lezion, , Israel
Kamogawa, , Japan
Shantou, , China
Chieti, , Italy
Rozzano, , Italy
Bucharest, , Romania
Iasi, , Romania
Brezno, , Slovakia
Tainan, , Taiwan
Swansea, , United Kingdom
Langhorne, Pennsylvania, United States
Bahia Blanca, , Argentina
Shanghai, , China
Concepcion, , Chile
Shanghai, , China
Aligarh, , India
Changhua, , Taiwan
Pancevo, , Serbia
Blagoevgrad, , Bulgaria
Siedlce, , Poland
Cape Town, , South Africa
Taichung, , Taiwan
Eindhoven, Brabant, Netherlands
Duluth, Minnesota, United States
Emmen, , Netherlands
Constanta, , Romania
Pomona, New Jersey, United States
Buffalo, New York, United States
Oradea, , Romania
Chicago, Illinois, United States
Valencia, , Spain
Greenville, South Carolina, United States
Jackson, Michigan, United States
Humble, Texas, United States
Garran, , Australia
Sao Paulo, , Brazil
Ottawa, Ontario, Canada
Bikaner, , India
Mumbai, , India
Vijayawada, , India
Porto Alegre, , Brazil
Brick, New Jersey, United States
Gangseo Gu, , Korea, Republic Of
Mexico, , Mexico
Davao City, , Philippines
Nantes Cedex 1, , France
Cleveland, Ohio, United States
Zvolen, , Slovakia
Amagasaki Shi, , Japan
Izunokuni Shi, , Japan
Nishinomiya Shi, , Japan
Venado Tuerto, , Argentina
Hialeah, Florida, United States
Guimaraes, , Portugal
Washington, District Of Columbia, United States
Greenville, South Carolina, United States
Surrey, British Columbia, Canada
Ferrara, , Italy
Roma, , Italy
Manila, , Philippines
Hobart, , Australia
Kingswood, , Australia
Milton, , Australia
Slany, , Czechia
Frankfurt, , Germany
Wakayama, , Japan
Newark, New Jersey, United States
Pau Cedex, , France
Osaka, , Japan
Seoul, , Korea, Republic Of
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Viña Del Mar, , Chile
Ciudad Autonoma Buenos Aires, , Argentina
Salvador, , Brazil
Utrecht, , Netherlands
Belgrade, , Serbia
Torun, , Poland
Tarragona, , Spain
Skierniewice, , Poland
Cape Town, , South Africa
Cape Town, , South Africa
Malaga, , Spain
Kayseri, , Turkey
Przemysl, , Poland
Shanghai, , China
Wenzhou, , China
Lisboa, , Portugal
Belgrade, , Serbia
Fukuoka, , Japan
Viña Del Mar, , Chile
New York, New York, United States
Ribeirao Preto, , Brazil
Dongguan, , China
Hangzhou, , China
Shanghai, , China
Xian, , China
Montpellier, , France
Napoli, , Italy
Torrette Di Ancona, , Italy
Urayasu Shi, , Japan
Bucheon Si, , Korea, Republic Of
Kaohsiung, , Taiwan
Matthews, North Carolina, United States
Belo Horizonte, , Brazil
Torquay, , United Kingdom
Yeovil, , United Kingdom
Chesterfield, Missouri, United States
Campinas, , Brazil
Hanoi, , Vietnam
Tacoma, Washington, United States
Strasbourg, , France
Chiba, , Japan
Taipei, , Taiwan
Botucatu, , Brazil
Bangkoknoi, , Thailand
Taichung, , Taiwan
Lubbock, Texas, United States
Bahia Blanca, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Manila, , Philippines
Manila, , Philippines
Manila, , Philippines
Hialeah, Florida, United States
Peoria, Illinois, United States
Tulsa, Oklahoma, United States
Kingwood, Texas, United States
La Crosse, Wisconsin, United States
Coronel Suarez, , Argentina
Taiyuan, , China
New Delhi, , India
Sesto San Giovanni, , Italy
Kamogawa, , Japan
Daejeon, , Korea, Republic Of
Seoul, , Korea, Republic Of
Sremska Mitrovica, , Serbia
Barcelona, , Spain
Afyon, , Turkey
San Diego, California, United States
Anderson, South Carolina, United States
Rapid City, South Dakota, United States
Murdoch, , Australia
Sydney, , Australia
Gyeonggi Do, , Korea, Republic Of
Seoul, , Korea, Republic Of
Greenville, South Carolina, United States
Nanyang, , China
Xinxiang, , China
Pelotas, , Brazil
Plovdiv, , Bulgaria
Kyoto, , Japan
Matsudo Shi, , Japan
Nagoya Shi, , Japan
Okayama Shi, , Japan
Saitama Shi, , Japan
Enschede, Overijssel, Netherlands
Gouda, Zuid Holland, Netherlands
Salvador, , Brazil
Ho Chi Minh, , Vietnam
Sao Paulo, , Brazil
Thomasville, Georgia, United States
Sofia, , Bulgaria
Sofia, , Bulgaria
Nanchang, , China
S Hertogenbosch, , Netherlands
Tokushima, , Japan
Timisoara, , Romania
Rockville, Maryland, United States
Ahmedabad, , India
Shimoga, , India
Ludhiana, , India
Barcelona, , Spain
Bangkok, , Thailand
Middlesbrough, , United Kingdom
Bad Nauheim, , Germany
Dresden, , Germany
Tokyo, , Japan
Zutphen, , Netherlands
Chikushino Shi, , Japan
Sejong Si, , Korea, Republic Of
Geneve 14, , Switzerland
Porto Alegre, , Brazil
Edinburgh, , United Kingdom
Isleworth, , United Kingdom
Portsmouth, , United Kingdom
Guangzhou, , China
Itabashi Ku, , Japan
Deventer, Overijssel, Netherlands
Maastricht, Limburg, Netherlands
Sneek, , Netherlands
Vigo, , Spain
Taipei City, , Taiwan
Nai Mueang Subdistrict Mueang, , Thailand
Newcastle Upon Tyne, , United Kingdom
Itabashi Ku, , Japan
Kochi, , Japan
Wuhan, , China
Chennai, , India
Kolkata, , India
Exeter, , United Kingdom
Vishakhapatnam, , India
Kfar Sava, , Israel
East Kilbride, , United Kingdom
Jamaica, New York, United States
Incheon, , Korea, Republic Of
Seoul, , Korea, Republic Of
Kanagawa, , Japan
Madrid, , Spain
Lanham, Maryland, United States
Paris Cedex 14, , France
Haifa, , Israel
Roosendaal, , Netherlands
Malaga, , Spain
Kuala Lumpur, , Malaysia
Skopje, , North Macedonia
Davao City, , Philippines
Ludwigshafen, , Germany
Belgaum, , India
Chiba, , Japan
Tokyo, , Japan
Tsukuba Shi, , Japan
Yokohama, , Japan
Busan, , Korea, Republic Of
Karabuk, , Turkey
Kutahya, , Turkey
Columbia, Missouri, United States
Pasadena, California, United States
Warszawa, , Poland
Coimbra, , Portugal
Lugano, , Switzerland
Gainesville, Florida, United States
Louisville, Kentucky, United States
Brasilia, , Brazil
St Catharines, Ontario, Canada
Houma, Louisiana, United States
Singapore, , Singapore
High Point, North Carolina, United States
Bethlehem, Pennsylvania, United States
Traralgon, , Australia
Mons, , Belgium
Fort Wayne, Indiana, United States
Overland Park, Kansas, United States
Bloomfield Hills, Michigan, United States
Norfolk, Virginia, United States
Marshfield, Wisconsin, United States
Belo Horizonte, , Brazil
Santa Rosa, California, United States
Sao Jose Do Rio Preto, , Brazil
Zagreb, , Croatia
Szolnok, , Hungary
Worms, , Germany
Athens, , Greece
Chiba, , Japan
Chicago, Illinois, United States
Newmarket, Ontario, Canada
Santiago, , Chile
Beijing, , China
Athens, , Greece
Yangsan Si, , Korea, Republic Of
Poznan, , Poland
Deventer, , Netherlands
Przemysl, , Poland
Cincinnati, Ohio, United States
Chengdu, , China
Columbus, Ohio, United States
Seoul, , Korea, Republic Of
Adelaide, , Australia
Xalapa, , Mexico
Halifax, Nova Scotia, Canada
Toronto, Ontario, Canada
Fukuoka Shi, , Japan
Clearwater, Florida, United States
Safety Harbor, Florida, United States
Oak Ridge, Tennessee, United States
Lille Cedex, , France
Potigny, , France
Mannheim, , Germany
Cochin, , India
Surat, , India
Patients applied
Trial Officials
Janssen Research & Development, LLC Clinical Trial
Study Director
Janssen Research & Development, LLC
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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