A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
Launched by JANSSEN RESEARCH & DEVELOPMENT, LLC · Feb 23, 2023
Trial Information
Current as of August 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a medication called milvexian to see if it can help reduce the risk of serious heart problems in patients who have recently experienced an acute coronary syndrome (ACS), which includes conditions like heart attacks. The goal is to find out if milvexian works better than a placebo (a harmless pill with no active ingredients) when given alongside standard heart care treatments.
To be eligible for this study, participants should be aged 65 or older and must have had a recent heart issue that meets specific criteria, such as elevated heart-related markers in the blood. They should also have at least two additional risk factors for heart disease, such as having diabetes or a history of heart problems. If you or a loved one is interested in participating, you'll receive regular check-ups and monitoring throughout the trial. It's important to note that women who can become pregnant will need to take precautions, as pregnancy is not allowed during the study. Overall, this trial aims to find new ways to protect heart health after serious events.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction \[STEMI\], non-STEMI, or unstable angina \[UA\]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB \[CK-MB\]) above the upper limit of normal as determined by the local laboratory
- • Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention \[PCI\] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (\>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- • All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- • A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
- Exclusion Criteria:
- • MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- • Planned CABG or staged PCI after randomization
- • Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- • Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
About Janssen Research & Development, Llc
Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson, is a leading pharmaceutical company dedicated to advancing innovative therapies in multiple therapeutic areas, including oncology, immunology, neuroscience, infectious diseases, and cardiovascular health. With a strong commitment to scientific excellence and patient-centered research, Janssen leverages cutting-edge technology and collaborative partnerships to drive the development of transformative treatments. The company is focused on addressing unmet medical needs through rigorous clinical trials and a robust pipeline, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Fort Worth, Texas, United States
Winnipeg, Manitoba, Canada
Patna, , India
Nishinomiya Shi, , Japan
Barcelona, , Spain
Shinagawa, , Japan
Fremont, California, United States
Birmingham, Alabama, United States
Mobile, Alabama, United States
Phoenix, Arizona, United States
Scottsdale, Arizona, United States
Tucson, Arizona, United States
La Jolla, California, United States
Munster, Indiana, United States
Saginaw, Michigan, United States
Bridgewater, New Jersey, United States
Sherman, Texas, United States
Austria, , Austria
Wiener Neustadt, , Austria
Brussels, , Belgium
Curitiba, , Brazil
Passo Fundo, , Brazil
Porto Alegre, , Brazil
Ribeirao Preto, , Brazil
Salvador, , Brazil
Vitória, , Brazil
Newmarket, Ontario, Canada
Beijing, , China
Hangzhou, , China
Nanjing, , China
Suzhou, , China
Tianjin, , China
Wuhan, , China
Xi'an, Shaanxi, China
Krapinske Toplice, , Croatia
Ostrava, , Czechia
Prague, , Czechia
Frankfurt, , Germany
Luedenscheid, , Germany
Magdeburg, , Germany
Mainz, , Germany
Zalaegerszeg, , Hungary
Bangalore, , India
Belgaum, , India
Kolkata, , India
Mumbai, , India
Milano, , Italy
Roma, , Italy
Seoul, , Korea, Republic Of
Athens, , Greece
Seoul, , Korea, Republic Of
Yangsan Si, , Korea, Republic Of
Kaunas, , Lithuania
Panevezys, , Lithuania
Kota Bharu, , Malaysia
Kota Kinabalu, , Malaysia
Guadalajara, , Mexico
Xalapa, , Mexico
Almelo, , Netherlands
Den Haag, , Netherlands
Goes, , Netherlands
Gouda, , Netherlands
Muntinlupa, , Philippines
Pasig City, , Philippines
Ostrowiec Swietokrzyski, , Poland
Adana, , Turkey
Antalya, , Turkey
Malatya, , Turkey
Saint Louis, Missouri, United States
Cordoba, , Argentina
Yichang, , China
Samsun, , Turkey
Blackpool, , United Kingdom
Ho Chi Minh, , Vietnam
Mainz, , Germany
Heraklion, , Greece
Hanoi, , Vietnam
Yinchuan, , China
Bialystok, , Poland
Sao Bernardo Do Campo, , Brazil
Kingston Upon Thames, , United Kingdom
Houston, Texas, United States
Cordoba, , Argentina
São Paulo, , Brazil
Vitória, , Brazil
Changchun, , China
Bonn Beuel, , Germany
Ho Chi Minh, , Vietnam
Leverkusen, , Germany
Brasov, , Romania
Jacksonville, Florida, United States
Cartersville, Georgia, United States
Taunton, , United Kingdom
El Paso, Texas, United States
Nice Cedex 1, , France
Rouen, , France
Bielefeld, , Germany
Votuporanga, , Brazil
Szeged, , Hungary
Bologna, , Italy
Centurion, , South Africa
Taoyuan County, , Taiwan
Stevenage, , United Kingdom
Bangor, Maine, United States
Plovdiv, , Bulgaria
Hangzhou, Zhejiang, China
Creteil, , France
Kolin, , Czechia
Auckland, , New Zealand
Otahuhu, , New Zealand
Xuzhou, , China
Yanji, , China
Springfield, Ohio, United States
Pembroke Pines, Florida, United States
Cordoba, , Argentina
Rotorua, , New Zealand
Cordoba, , Argentina
Terrebonne, Quebec, Canada
Budapest, , Hungary
Peterborough, , United Kingdom
Redding, California, United States
Amarillo, Texas, United States
Manila, , Philippines
Vila Real, , Portugal
Niska Banja, , Serbia
Bournemouth, , United Kingdom
Nashville, Tennessee, United States
Mobile, Alabama, United States
Recife, , Brazil
Dongguan, , China
Tampa, Florida, United States
Wenzhou, , China
Hiratsuka Shi, , Japan
Toyama Shi, , Japan
Tiel, , Netherlands
Englewood, New Jersey, United States
Praha 2, , Czechia
Guiyang, , China
Valhalla, New York, United States
Concord, , Australia
Rijeka, , Croatia
Szolnok, , Hungary
Tokyo, , Japan
Mazatlan, , Mexico
Nieuwegein, , Netherlands
Tetovo, , North Macedonia
Cavite, , Philippines
Mandaluyong, , Philippines
Quebec, , Canada
Zhanjiang, , China
Santa Maria Da Feira, , Portugal
Olsztyn, , Poland
Coimbra, , Portugal
Braga, , Portugal
Gurnee, Illinois, United States
Hanoi, , Vietnam
Baltimore, Maryland, United States
Tomball, Texas, United States
Wien, , Austria
Cambridge, Ontario, Canada
Temuco, , Chile
Hanoi, , Vietnam
Targu Mures, , Romania
Singapore, , Singapore
Ho Chi Minh, , Vietnam
Somerset West, , South Africa
Chongqing, , China
Taipei, , Taiwan
Tsu, , Japan
Aguascalientes, , Mexico
Springfield, Missouri, United States
Prague, , Czechia
Bursa, , Turkey
Plymouth, , United Kingdom
Sao Paulo, , Brazil
Vandoeuvre Les Nancy Cedex, , France
Bakersfield, California, United States
Santa Monica, California, United States
Brasov, , Romania
Sofia, , Bulgaria
Orange, Florida, United States
Stara Zagora, , Bulgaria
Sarasota, Florida, United States
Calgary, Alberta, Canada
Moncton, New Brunswick, Canada
Alexandroupolis, , Greece
Athens, , Greece
Chennai, , India
Hastings, , New Zealand
Durban, , South Africa
Somerset West, , South Africa
Barcelona, , Spain
Madrid, , Spain
Swansea, , United Kingdom
Chambersburg, Pennsylvania, United States
Aveiro, , Portugal
New Taipei, , Taiwan
Sao Paulo, , Brazil
Bonn, , Germany
Sarasota, Florida, United States
Atlanta, Georgia, United States
Nijmegen, , Netherlands
Peterborough, Ontario, Canada
Jacksonville, Florida, United States
Littleton, Colorado, United States
Madrid, , Spain
Ho Chi Minh, , Vietnam
Elkhart, Indiana, United States
Philadelphia, Pennsylvania, United States
Cordoba, , Argentina
Jihlava, , Czechia
Bitburg, , Germany
Kasuga Shi, , Japan
Wroclaw, , Poland
Poitiers, , France
Mossel Bay, , South Africa
Gijon, , Spain
Izmir, , Turkey
Covilha, , Portugal
Bucuresti, , Romania
Cape Town, , South Africa
London, , United Kingdom
Hyderbad, , India
Moenchengladbach, , Germany
Dorchester, , United Kingdom
Shiwa Gun, , Japan
Kuching, , Malaysia
Bucuresti, , Romania
Yilan County, , Taiwan
London, , United Kingdom
Afula, , Israel
Haifa, , Israel
Pavia, , Italy
Hamburg, , Germany
Florencio Varela, , Argentina
Cheongju Si, , Korea, Republic Of
Culiacan, , Mexico
Camperdown, , Australia
Madrid, , Spain
Gainesville, Georgia, United States
Springfield, Illinois, United States
Olsztyn, , Poland
Haifa, , Israel
Hradec Kralove, , Czechia
La Spezia, , Italy
Redhill, , United Kingdom
New York, New York, United States
Hanoi, , Vietnam
Dubrovnik, , Croatia
San Luis Potosí, , Mexico
Madrid, , Spain
Brasilia, , Brazil
Remscheid, , Germany
Ramat Gan, , Israel
Bern, , Switzerland
Helmond, , Netherlands
Mobile, Alabama, United States
San Diego, California, United States
Venlo, , Netherlands
Santa Rosa, California, United States
Saint Paul, Minnesota, United States
Kansas City, Missouri, United States
Birtinya, , Australia
Lenoir, North Carolina, United States
Curitiba, , Brazil
Curitiba, , Brazil
Guiyang, , China
Minot, North Dakota, United States
Huizhou, , China
Kyle, Texas, United States
Milano, , Italy
Brno, , Czechia
Saga, , Japan
Athens, , Greece
Athens, , Greece
Ureshino Shi, , Japan
Kuala Lumpur, , Malaysia
Harderwijk, , Netherlands
Leiderdorp, , Netherlands
Shinagawa, , Japan
Krakow, , Poland
New Taipei, , Taiwan
Tainan, , Taiwan
Taipei, , Taiwan
Leeds, , United Kingdom
Ciudad Autonoma Buenos Aires, , Argentina
Nagpur, , India
Alkmaar, , Netherlands
Bath, , United Kingdom
Tokyo, , Japan
Wuxi, , China
Selayang, , Malaysia
Sao Paulo, , Brazil
Linfen, , China
Osaka Shi, , Japan
Sofia, , Bulgaria
Amersfoort, , Netherlands
Nanjing, , China
Basel, , Switzerland
Seberang Jaya, , Malaysia
Zajecar, , Serbia
Birmingham, Alabama, United States
Boca Raton, Florida, United States
Las Vegas, Nevada, United States
New York, New York, United States
Vilnius, , Lithuania
Nashville, Tennessee, United States
Everett, Washington, United States
Porto Alegre, , Brazil
Quebec, , Canada
Zalaegerszeg, , Hungary
Ashkelon, , Israel
Beijing, , China
West Bromwich, , United Kingdom
Seoul, , Korea, Republic Of
Bronx, New York, United States
Kota Bahru, , Malaysia
Newport Beach, California, United States
Gainesville, Georgia, United States
Huntsville, Alabama, United States
Hazel Crest, Illinois, United States
Fort Wayne, Indiana, United States
Bethesda, Maryland, United States
Salisbury, Maryland, United States
Saginaw, Michigan, United States
Tupelo, Mississippi, United States
Chicago, Illinois, United States
Kansas City, Missouri, United States
Lincoln, Nebraska, United States
Bronx, New York, United States
Chapel Hill, North Carolina, United States
Kettering, Ohio, United States
Jackson, Tennessee, United States
Rock Hill, South Carolina, United States
Amarillo, Texas, United States
El Paso, Texas, United States
Leesburg, Virginia, United States
Nashville, Tennessee, United States
Tacoma, Washington, United States
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Junin, , Argentina
Quilmes, , Argentina
Cordoba, , Argentina
Rosario, , Argentina
Salta, , Argentina
Salta, , Argentina
Rosario, , Argentina
San Miguel De Tucuman, , Argentina
San Nicolas, , Argentina
Santa Fe, , Argentina
Santa Fe, , Argentina
Villa Maria, , Argentina
Santa Fe, , Argentina
Ballarat, , Australia
Cairns, , Australia
Adelaide, , Australia
Clayton, , Australia
Graz, , Austria
Innsbruck, , Austria
Vienna, , Austria
Wien, , Austria
Brasschaat, , Belgium
Brugge, , Belgium
Bruxelles, , Belgium
Bruxelles, , Belgium
Genk, , Belgium
Liege, , Belgium
Linz, , Austria
Mechelen, , Belgium
Mol, , Belgium
Roeselare, , Belgium
Liège, , Belgium
Belo Horizonte, , Brazil
Brasília, , Brazil
Belo Horizonte, , Brazil
Campinas, , Brazil
Criciúma, , Brazil
Curitiba, , Brazil
Goiania, , Brazil
Marilia, , Brazil
Natal, , Brazil
Porto Alegre, , Brazil
Salvador, , Brazil
Santo André, , Brazil
Sao Jose Do Rio Preto, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
São Jose Do Rio Preto, , Brazil
São José, , Brazil
Uberaba, , Brazil
Burgas, , Bulgaria
Gabrovo, , Bulgaria
Panagyurishte, , Bulgaria
Pernik, , Bulgaria
Sofia, , Bulgaria
Pleven, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Edmonton, Alberta, Canada
Vancouver, British Columbia, Canada
Sofia, , Bulgaria
London, Ontario, Canada
Windsor, Ontario, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
St Jean Sur Richelieu, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Quebec, , Canada
Talcahuano, , Chile
Hamilton, Ontario, Canada
Baotou, , China
Beijing, , China
Beijing, , China
Beijing, , China
Beijing, , China
Beijing, , China
Changsha, , China
Changzhou, , China
Chengdu, , China
Chengdu, , China
Fuzhou, , China
Guiyang, , China
Hangzhou, , China
Hangzhou, , China
Jinan, , China
Lanzhou, , China
Nanchang, , China
Nanjing, , China
Jining, , China
Shenzhen, , China
Wenzhou, , China
Wenzhou, , China
Wulumuqi, , China
Zunyi, , China
Cakovec, , Croatia
Slavonski Brod, , Croatia
Su Zhou, , China
Zabok, , Croatia
Zagreb, , Croatia
Wuhan, , China
Thessaloniki, , Greece
Brno, , Czechia
Ceske Budejovice, , Czechia
Liberec, , Czechia
Plzen, , Czechia
Prague, , Czechia
Praha 2, , Czechia
Copenhagen S, , Denmark
Jerusalem, , Israel
Frederiksberg, , Denmark
Holbæk, , Denmark
Brno, , Czechia
Koge, , Denmark
Slagelse, , Denmark
ålborg, , Denmark
Hvidovre, , Denmark
Tallinn, , Estonia
Chambray Les Tours, , France
San Martin, , Argentina
La Tronche, , France
Le Coudray, , France
Corbeil Essonnes Cedex, , France
Lille Cedex, , France
Lyon, , France
Nîmes Cedex 9, , France
Montauban, , France
Rouen Cedex, , France
Berlin, , Germany
Berlin, , Germany
Paris, , France
Coburg, , Germany
Dortmund, , Germany
Duesseldorf, , Germany
Berlin, , Germany
Greifswald, , Germany
Neuwied, , Germany
Rostock, , Germany
Worms, , Germany
Athens Attica, , Greece
Hamburg, , Germany
Ioannina, , Greece
Larissa, , Greece
Athens, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Patra, , Greece
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Budapest, , Hungary
Gyula, , Hungary
Miskolc, , Hungary
Gyor, , Hungary
Pecs, , Hungary
Szekszárd, , Hungary
Bangalore, , India
Amritsar, , India
Faridabad, , India
Delhi, , India
Kolkata, , India
Kolkata, , India
Mangalore, , India
Hyderabad, , India
Mysore, , India
Nagpur, , India
Pune, , India
Nagpur, , India
Ulhasnagar, , India
Ashdod, , Israel
Beersheba, , Israel
Haifa, , Israel
Holon, , Israel
Jerusalem, , Israel
Jerusalem, , Israel
Kfar Sava, , Israel
Rechovot, , Israel
Tiberias, , Israel
Milano, , Italy
Pisa, , Italy
Roma, , Italy
Safed, , Israel
Sassari, , Italy
Seriate, , Italy
Treviglio, , Italy
Treviso, , Italy
Fukuoka Shi, , Japan
Chiba, , Japan
Himeji Shi, , Japan
Isehara, , Japan
Kitakyushu Shi, , Japan
Hiroshima, , Japan
Kure Shi, , Japan
Koga, , Japan
Matsumoto Shi, , Japan
Minato Ku, , Japan
Miyazaki Shi, , Japan
Okayama Shi, , Japan
Saitama, , Japan
Meguro Ku, , Japan
Sendai, , Japan
Shinjuku Ku, , Japan
Suita Shi, , Japan
Tokyo, , Japan
Tokyo, , Japan
Tokyo, , Japan
Tokyo, , Japan
Ube, , Japan
Urayasu Shi, , Japan
Busan, , Korea, Republic Of
Busan, , Korea, Republic Of
Busan, , Korea, Republic Of
Gangseo Gu, , Korea, Republic Of
Gwangju, , Korea, Republic Of
Incheon, , Korea, Republic Of
Sejong Si, , Korea, Republic Of
Seoul, , Korea, Republic Of
Chuncheon, , Korea, Republic Of
Wonju, , Korea, Republic Of
Seoul, , Korea, Republic Of
Daugavpils, , Latvia
Riga, , Latvia
Kaunas, , Lithuania
Klaipeda, , Lithuania
Siauliai, , Lithuania
Liepaja, , Latvia
Jalapa, , Mexico
San Luis Potosí, , Mexico
Tijuana, , Mexico
Ede, , Netherlands
Eindhoven, , Netherlands
Amsterdam, , Netherlands
Enschede, , Netherlands
Roermond, , Netherlands
Rotterdam, , Netherlands
Zutphen, , Netherlands
Veldhoven, , Netherlands
Tauranga, , New Zealand
Dasmarinas, , Philippines
Dunedin, , New Zealand
San Juan, , Philippines
Quezon, , Philippines
Lodz, , Poland
Lublin, , Poland
Oswiecim, , Poland
Torun, , Poland
Naleczow, , Poland
Warszawa, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Zabrze, , Poland
Coimbra, , Portugal
Guimarães, , Portugal
Lisboa, , Portugal
Wałbrzych, , Poland
Baia Mare, , Romania
Lisbon, , Portugal
Cluj Napoca, , Romania
Cluj Napoca, , Romania
Bucuresti, , Romania
Pitesti, , Romania
Timisoara, , Romania
Timisoara, , Romania
Belgrade, , Serbia
Kragujevac, , Serbia
Uzice, , Serbia
Singapore, , Singapore
Bardejov, , Slovakia
Targu Mures, , Romania
Bratislava, , Slovakia
Kosice, , Slovakia
Kosice, , Slovakia
Lucenec, , Slovakia
Moldava Nad Bodvou, , Slovakia
Košice, , Slovakia
Presov, , Slovakia
Svidnik, , Slovakia
Zilina, , Slovakia
Bloemfontein, , South Africa
Johannesburg, , South Africa
Manchester, , United Kingdom
Alicante, , Spain
Madrid, , Spain
Pamplona, , Spain
Cary, North Carolina, United States
Budapest, , Hungary
Ciudad Autonoma De Buenos Aires, , Argentina
Zuerich, , Switzerland
Lublin, , Poland
Kaohsiung, , Taiwan
Ankara, , Turkey
Pathum Wan, , Thailand
Ankara, , Turkey
Istanbul, , Turkey
Lleida, , Spain
Gunma, , Japan
Northridge, California, United States
Louisville, Kentucky, United States
Basingstoke, , United Kingdom
Falls Church, Virginia, United States
Maastricht, , Netherlands
Porto Alegre, , Brazil
Brandenburg An Der Havel, , Germany
Sanford, North Carolina, United States
Takamatsu, , Japan
Toledo, Ohio, United States
Mar Del Plata, , Argentina
Rosario, , Argentina
Salta, , Argentina
Elizabeth Vale, , Australia
Wollongong, , Australia
Woodville South, , Australia
La Plata, , Argentina
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Recife, , Brazil
Tartu, , Estonia
Porto Alegre, , Brazil
Recife, , Brazil
Dijon Cedex, , France
Limoges, , France
Paris, , France
Nagoya Shi, , Japan
Tsukuba City, , Japan
Daegu, , Korea, Republic Of
Riga, , Latvia
Davao City, Davao Del Sur, , Philippines
Ilocos Sur, , Philippines
Iloilo City, , Philippines
Bydgoszcz, , Poland
Elbląg, , Poland
Krakow, , Poland
Warszawa, , Poland
Pessac, , France
Tradate, , Italy
Wroclaw, , Poland
Almada, , Portugal
Leiria, , Portugal
Aveiro, , Portugal
Bucharest, , Romania
Vila Nova De Gaia, , Portugal
Belgrade, , Serbia
Bucuresti, , Romania
Cluj Napoca, , Romania
Belgrade, , Serbia
Ha Noi, , Vietnam
Paris, , France
Toulouse Cedex 9, , France
Berlin, , Germany
Sopot, , Poland
Bucuresti, , Romania
Akron, Ohio, United States
Brasilia, , Brazil
Campina Grande Do Sul, , Brazil
Nagoya Shi, , Japan
Daejeon, , Korea, Republic Of
Guimaraes, , Portugal
Barcelona, , Spain
Kaposvar, , Hungary
Christchurch, , New Zealand
Barcelona, , Spain
Manises, , Spain
Saitama Shi, , Japan
Campinas, , Brazil
Pomona, New Jersey, United States
Angers, , France
Zaragoza, , Spain
Taipei, , Taiwan
Taipei, , Taiwan
Gyeonggi Do, , Korea, Republic Of
Thessaloniki, , Greece
Bergamo, , Italy
Kaohsiung, , Taiwan
Hirosaki, , Japan
Salvador, , Brazil
Nagpur, , India
Amagasaki Shi, , Japan
Singapore, , Singapore
Jacksonville, Florida, United States
Duluth, Minnesota, United States
Martin, , Slovakia
Winchester, Virginia, United States
El Paso, Texas, United States
Stockton, California, United States
Katowice, , Poland
Krakow, , Poland
Angers, , France
Ankara, , Turkey
Petah Tikva, , Israel
Danbury, Connecticut, United States
Poitiers, , France
Stamford, Connecticut, United States
Little Rock, Arkansas, United States
Fort Lauderdale, Florida, United States
Gilbert, Arizona, United States
Southport, , Australia
Palo Alto, California, United States
San Diego, California, United States
Levis, Quebec, Canada
Peoria, Illinois, United States
Richmond, Indiana, United States
Shreveport, Louisiana, United States
Slidell, Louisiana, United States
Haverhill, Massachusetts, United States
Bay City, Michigan, United States
Grand Blanc, Michigan, United States
Poughkeepsie, New York, United States
Trumbull, Connecticut, United States
Ciudad Autonoma De Buenos Aires, , Argentina
Rosario, , Argentina
Adelaide, South Australia, Australia
Herston, , Australia
Caba, , Argentina
Edegem, , Belgium
Gent, , Belgium
Braunau Am Inn, , Austria
Belo Horizonte, , Brazil
Curitiba, , Brazil
Hasselt, , Belgium
Pelotas, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
São Paulo, , Brazil
Haskovo, , Bulgaria
Oakville, Ontario, Canada
Puerto Varas, , Chile
Santiago, , Chile
Dongguan, , China
Guangzhou, , China
Hefei, , China
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Ningbo, , China
Ostrava Poruba, , Czechia
Tianjin, , China
Pardubice, , Czechia
Praha 10, , Czechia
Praha 4, , Czechia
Herlev, , Denmark
Montpellier, , France
Viborg, , Denmark
Vandoeuvre Les Nancy Cedex, , France
Versailles Cedex, , France
Bad Krozingen, , Germany
Bremen, , Germany
Dresden, , Germany
Erfurt, , Germany
Tübingen, , Germany
New Delhi, , India
Surat, , India
Mestre, , Italy
Milano, , Italy
Aichi, , Japan
Ishikawa, , Japan
Kumamoto Shi, , Japan
Kurashiki, , Japan
Matsudo Shi, , Japan
Nagano Shi, , Japan
Kisarazu Shi, , Japan
Osaka, , Japan
Tokyo, , Japan
Yokohama, , Japan
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Torreon, , Mexico
Monterrey, , Mexico
Auckland, , New Zealand
Nijmegen, , Netherlands
Baguio City, , Philippines
Quezon City, , Philippines
New Plymouth, , New Zealand
Worcester, , South Africa
Nitra, , Slovakia
Craiova, , Romania
El Palmar, , Spain
Santiago De Compostela, , Spain
Tg. Mures, , Romania
Taipei, , Taiwan
Valencia, , Spain
Raleigh, North Carolina, United States
Urbana, Illinois, United States
Harrisburg, Pennsylvania, United States
Jackson, Mississippi, United States
Wynnewood, Pennsylvania, United States
Feldkirch, , Austria
Chengdu, , China
Criciúma, , Brazil
Sao Paulo, , Brazil
Jinan, , China
Porto Alegre, , Brazil
Mulhouse Cedex, , France
Wakayama, , Japan
Seoul, , Korea, Republic Of
Fukui Shi, , Japan
Fukuoka, , Japan
Gifu, , Japan
San Diego, California, United States
Naples, Florida, United States
Wellington, Florida, United States
Hampstead, , United Kingdom
Ann Arbor, Michigan, United States
Lansing, Michigan, United States
Sherman, Texas, United States
Harefield, , United Kingdom
Salvador, , Brazil
Sao Jose Do Rio Preto, , Brazil
Vancouver, British Columbia, Canada
Tianjin, , China
Tianjin, , China
Trinec, , Czechia
Budapest, , Hungary
Trois Rivières, Quebec, Canada
Kecskemet, , Hungary
Whangarei, , New Zealand
Przemysl, , Poland
Nove Zamky, , Slovakia
Birmingham, Alabama, United States
Sarasota, Florida, United States
Turnhout, , Belgium
Belo Horizonte, , Brazil
Ceske Budejovice, , Czechia
Pardubice, , Czechia
Pune, , India
Wuhan, , China
Phoenix, Arizona, United States
Herning, , Denmark
Coeur D'alene, Idaho, United States
Omaha, Nebraska, United States
Muncie, Indiana, United States
Palo Alto, California, United States
Somerset, New Jersey, United States
Downers Grove, Illinois, United States
Bahia Blanca, , Argentina
Cordoba, , Argentina
Vina Del Mar, , Chile
Sta Rosa, , Philippines
Mainz, , Germany
Elblag, , Poland
Krakow, , Poland
Bialystok, , Poland
Bydgoszcz, , Poland
Poznan, , Poland
Sopot, , Poland
Lublin, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Wigan, , United Kingdom
Athens, , Greece
Belgrade, , Serbia
Kumamoto City, , Japan
Olsztyn, , Poland
Vitoria, , Brazil
Temuco, , Chile
Aahus N, , Denmark
Chieti, , Italy
Pulau Pinang, , Malaysia
Cebu, , Philippines
Davao, , Philippines
Marikina City, , Philippines
Leicester, , United Kingdom
Lincoln, , United Kingdom
Oklahoma City, Oklahoma, United States
Tatuí, , Brazil
Changzhou, , China
Hangzhou, , China
Lipa City, , Philippines
Kielce, , Poland
Szombathely, , Hungary
Kyoto Shi, , Japan
Smederevo, , Serbia
Istanbul, , Turkey
Kuala Lumpur, , Malaysia
Mersin, , Turkey
Queretaro, , Mexico
Bad Friedrichshall, , Germany
Iloilo, , Philippines
Bristol, , United Kingdom
Fort Lauderdale, Florida, United States
Miami, Florida, United States
New Orleans, Louisiana, United States
Caen Cedex, , France
West Monroe, Louisiana, United States
Poços De Caldas, , Brazil
Pleven, , Bulgaria
Milano, , Italy
Dudley, , United Kingdom
Chattanooga, Tennessee, United States
Thomasville, Georgia, United States
Houston, Texas, United States
Rouen Cedex, , France
Trinity, Florida, United States
Sagamihara, , Japan
Bruxelles, , Belgium
Bruxelles, , Belgium
Tokyo, , Japan
Lugano, Ticino, Switzerland
Bonheiden, , Belgium
Sendai, , Japan
Bytom, , Poland
Tokyo, , Japan
Heerlen, , Netherlands
Torun, , Poland
Walbrzych, , Poland
Zhongshan, , China
Vila Nova De Gaia, , Portugal
Sremska Kamenica, , Serbia
Greensboro, North Carolina, United States
Erie, Pennsylvania, United States
Newport News, Virginia, United States
North Miami Beach, Florida, United States
Bytom, , Poland
Londonderry, , United Kingdom
Bartlesville, Oklahoma, United States
Svendborg, , Denmark
Alexander City, Alabama, United States
La Tronche, , France
Goyang Si, , Korea, Republic Of
Banska Bystrica, , Slovakia
Nis, , Serbia
Singapore, , Singapore
Madrid, , Spain
Angeles, , Philippines
Loxahatchee Groves, Florida, United States
Ciudad Autonoma Buenos Aires, , Argentina
Jerusalem, , Israel
Naharya, , Israel
Parma, , Italy
Nanjing, , China
Hamburg, , Germany
Sremska Kamenica, , Serbia
Chiangmai, , Thailand
Taipei, , Taiwan
Rishon Lezion, , Israel
Zhengzhou, , China
Kanazawa Shi, , Japan
San Diego, California, United States
Alexandria, Louisiana, United States
Kamogawa, , Japan
Zhongshan, , China
Szekszárd, , Hungary
Alessandria, , Italy
Bergamo, , Italy
Roma, , Italy
Tsuchiura City, , Japan
Flint, Michigan, United States
Santo Andre, , Brazil
Eskisehir, , Turkey
Birmingham, , United Kingdom
Palos Hills, Illinois, United States
Langhorne, Pennsylvania, United States
Shantou, , China
Chieti, , Italy
Rozzano, , Italy
Bucharest, , Romania
Seoul, , Korea, Republic Of
Iasi, , Romania
Brezno, , Slovakia
Swansea, , United Kingdom
Tainan, , Taiwan
Concepcion, , Chile
Shanghai, , China
Bahia Blanca, , Argentina
Aligarh, , India
Shanghai, , China
Pancevo, , Serbia
Changhua, , Taiwan
Eindhoven, Brabant, Netherlands
Emmen, , Netherlands
Cape Town, , South Africa
Taichung, , Taiwan
Duluth, Minnesota, United States
Pomona, New Jersey, United States
Blagoevgrad, , Bulgaria
Siedlce, , Poland
Buffalo, New York, United States
Constanta, , Romania
Chicago, Illinois, United States
Oradea, , Romania
Jackson, Michigan, United States
Valencia, , Spain
Sao Paulo, , Brazil
Ottawa, Ontario, Canada
Greenville, South Carolina, United States
Bikaner, , India
Mumbai, , India
Humble, Texas, United States
Vijayawada, , India
Gangseo Gu, , Korea, Republic Of
Mexico, , Mexico
Davao City, , Philippines
Brick, New Jersey, United States
Garran, , Australia
Nantes Cedex 1, , France
Zvolen, , Slovakia
Cleveland, Ohio, United States
Porto Alegre, , Brazil
Hialeah, Florida, United States
Amagasaki Shi, , Japan
Izunokuni Shi, , Japan
Venado Tuerto, , Argentina
Guimaraes, , Portugal
Pau Cedex, , France
Nishinomiya Shi, , Japan
Washington, District Of Columbia, United States
Osaka, , Japan
Greenville, South Carolina, United States
Surrey, British Columbia, Canada
Seoul, , Korea, Republic Of
Ferrara, , Italy
Hobart, , Australia
Kingswood, , Australia
Milton, , Australia
Roma, , Italy
Manila, , Philippines
Slany, , Czechia
Frankfurt, , Germany
Wakayama, , Japan
Newark, New Jersey, United States
Ciudad Autonoma Buenos Aires, , Argentina
Salvador, , Brazil
Sao Paulo, , Brazil
Utrecht, , Netherlands
Torun, , Poland
Belgrade, , Serbia
Tarragona, , Spain
Przemysl, , Poland
Skierniewice, , Poland
Cape Town, , South Africa
Cape Town, , South Africa
Malaga, , Spain
Sao Paulo, , Brazil
Viña Del Mar, , Chile
Kayseri, , Turkey
Viña Del Mar, , Chile
Fukuoka, , Japan
New York, New York, United States
Matthews, North Carolina, United States
Shanghai, , China
Wenzhou, , China
Belo Horizonte, , Brazil
Ribeirao Preto, , Brazil
Lisboa, , Portugal
Dongguan, , China
Belgrade, , Serbia
Hangzhou, , China
Napoli, , Italy
Shanghai, , China
Xian, , China
Torrette Di Ancona, , Italy
Montpellier, , France
Urayasu Shi, , Japan
Kaohsiung, , Taiwan
Bucheon Si, , Korea, Republic Of
Taichung, , Taiwan
Chesterfield, Missouri, United States
Campinas, , Brazil
Torquay, , United Kingdom
Hanoi, , Vietnam
Tacoma, Washington, United States
Yeovil, , United Kingdom
Taipei, , Taiwan
Botucatu, , Brazil
Strasbourg, , France
Bangkoknoi, , Thailand
Chiba, , Japan
Lubbock, Texas, United States
Bahia Blanca, , Argentina
Nanyang, , China
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Manila, , Philippines
Xinxiang, , China
Hialeah, Florida, United States
Manila, , Philippines
Manila, , Philippines
Peoria, Illinois, United States
Kingwood, Texas, United States
Tulsa, Oklahoma, United States
La Crosse, Wisconsin, United States
Taiyuan, , China
New Delhi, , India
Sesto San Giovanni, , Italy
Coronel Suarez, , Argentina
Seoul, , Korea, Republic Of
Kamogawa, , Japan
Daejeon, , Korea, Republic Of
Sremska Mitrovica, , Serbia
Barcelona, , Spain
Afyon, , Turkey
Anderson, South Carolina, United States
San Diego, California, United States
Rapid City, South Dakota, United States
Murdoch, , Australia
Gyeonggi Do, , Korea, Republic Of
Sydney, , Australia
Greenville, South Carolina, United States
Seoul, , Korea, Republic Of
Salvador, , Brazil
Ho Chi Minh, , Vietnam
Kyoto, , Japan
Matsudo Shi, , Japan
Nagoya Shi, , Japan
Okayama Shi, , Japan
Pelotas, , Brazil
Plovdiv, , Bulgaria
Enschede, Overijssel, Netherlands
Gouda, Zuid Holland, Netherlands
Saitama Shi, , Japan
Sao Paulo, , Brazil
Thomasville, Georgia, United States
Nanchang, , China
Bad Nauheim, , Germany
S Hertogenbosch, , Netherlands
Tokushima, , Japan
Dresden, , Germany
Timisoara, , Romania
Tokyo, , Japan
Zutphen, , Netherlands
Rockville, Maryland, United States
Ludhiana, , India
Barcelona, , Spain
Bangkok, , Thailand
Middlesbrough, , United Kingdom
Edinburgh, , United Kingdom
Isleworth, , United Kingdom
Portsmouth, , United Kingdom
Sejong Si, , Korea, Republic Of
Geneve 14, , Switzerland
Sofia, , Bulgaria
Sofia, , Bulgaria
Chikushino Shi, , Japan
Porto Alegre, , Brazil
Ahmedabad, , India
Shimoga, , India
Guangzhou, , China
Itabashi Ku, , Japan
Deventer, Overijssel, Netherlands
Maastricht, Limburg, Netherlands
Sneek, , Netherlands
Vigo, , Spain
Taipei City, , Taiwan
Nai Mueang Subdistrict Mueang, , Thailand
Newcastle Upon Tyne, , United Kingdom
Itabashi Ku, , Japan
Wuhan, , China
Haifa, , Israel
Roosendaal, , Netherlands
Malaga, , Spain
Chennai, , India
Kolkata, , India
Exeter, , United Kingdom
Kochi, , Japan
Vishakhapatnam, , India
Jamaica, New York, United States
Kfar Sava, , Israel
Incheon, , Korea, Republic Of
East Kilbride, , United Kingdom
Seoul, , Korea, Republic Of
Lanham, Maryland, United States
Paris Cedex 14, , France
Ludwigshafen, , Germany
Kanagawa, , Japan
Belgaum, , India
Chiba, , Japan
Kuala Lumpur, , Malaysia
Skopje, , North Macedonia
Madrid, , Spain
Davao City, , Philippines
Warszawa, , Poland
Karabuk, , Turkey
Kutahya, , Turkey
Columbia, Missouri, United States
Tokyo, , Japan
Pasadena, California, United States
Gainesville, Florida, United States
Louisville, Kentucky, United States
Houma, Louisiana, United States
High Point, North Carolina, United States
Bethlehem, Pennsylvania, United States
Traralgon, , Australia
Mons, , Belgium
Brasilia, , Brazil
St Catharines, Ontario, Canada
Singapore, , Singapore
Fort Wayne, Indiana, United States
Overland Park, Kansas, United States
Bloomfield Hills, Michigan, United States
Norfolk, Virginia, United States
Marshfield, Wisconsin, United States
Szolnok, , Hungary
Coimbra, , Portugal
Lugano, , Switzerland
Newmarket, Ontario, Canada
Worms, , Germany
Athens, , Greece
Chiba, , Japan
Tsukuba Shi, , Japan
Yokohama, , Japan
Santiago, , Chile
Busan, , Korea, Republic Of
Chicago, Illinois, United States
Cincinnati, Ohio, United States
Columbus, Ohio, United States
Beijing, , China
Athens, , Greece
Yangsan Si, , Korea, Republic Of
Poznan, , Poland
Fukuoka Shi, , Japan
Deventer, , Netherlands
Przemysl, , Poland
Chengdu, , China
Seoul, , Korea, Republic Of
Xalapa, , Mexico
Santa Rosa, California, United States
Adelaide, , Australia
Natal, , Brazil
Sao Jose Do Rio Preto, , Brazil
Halifax, Nova Scotia, Canada
Belo Horizonte, , Brazil
Clearwater, Florida, United States
Safety Harbor, Florida, United States
Oak Ridge, Tennessee, United States
Lille Cedex, , France
Potigny, , France
Mannheim, , Germany
Cochin, , India
Toronto, Ontario, Canada
Zagreb, , Croatia
Miri, , Malaysia
Birmingham, , United Kingdom
Seoul, , Korea, Republic Of
Surat, , India
Patients applied
Trial Officials
Janssen Research & Development, LLC Clinical Trial
Study Director
Janssen Research & Development, LLC
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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