A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
Launched by JANSSEN RESEARCH & DEVELOPMENT, LLC · Feb 23, 2023
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a medication called milvexian to see if it can help reduce the risk of serious heart problems in patients who have recently experienced an acute coronary syndrome (ACS), which includes conditions like heart attacks. The goal is to find out if milvexian works better than a placebo (a harmless pill with no active ingredients) when given alongside standard heart care treatments.
To be eligible for this study, participants should be aged 65 or older and must have had a recent heart issue that meets specific criteria, such as elevated heart-related markers in the blood. They should also have at least two additional risk factors for heart disease, such as having diabetes or a history of heart problems. If you or a loved one is interested in participating, you'll receive regular check-ups and monitoring throughout the trial. It's important to note that women who can become pregnant will need to take precautions, as pregnancy is not allowed during the study. Overall, this trial aims to find new ways to protect heart health after serious events.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction \[STEMI\], non-STEMI, or unstable angina \[UA\]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB \[CK-MB\]) above the upper limit of normal as determined by the local laboratory
- • Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention \[PCI\] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (\>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- • All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- • A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
- Exclusion Criteria:
- • MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- • Planned CABG or staged PCI after randomization
- • Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- • Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
About Janssen Research & Development, Llc
Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson, is a leading pharmaceutical company dedicated to advancing innovative therapies in multiple therapeutic areas, including oncology, immunology, neuroscience, infectious diseases, and cardiovascular health. With a strong commitment to scientific excellence and patient-centered research, Janssen leverages cutting-edge technology and collaborative partnerships to drive the development of transformative treatments. The company is focused on addressing unmet medical needs through rigorous clinical trials and a robust pipeline, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Marshfield, Wisconsin, United States
New York, New York, United States
Nashville, Tennessee, United States
Bethesda, Maryland, United States
Washington, District Of Columbia, United States
Adelaide, South Australia, Australia
Peoria, Illinois, United States
Newark, New Jersey, United States
Montreal, Quebec, Canada
Bournemouth, , United Kingdom
Holon, , Israel
Las Vegas, Nevada, United States
Redhill, , United Kingdom
Urbana, Illinois, United States
Kansas City, Missouri, United States
Pomona, New Jersey, United States
Anderson, South Carolina, United States
Thessaloniki, , Greece
Vancouver, British Columbia, Canada
Saskatoon, Saskatchewan, Canada
Newport News, Virginia, United States
Montauban, , France
Gouda, , Netherlands
Cincinnati, Ohio, United States
Akron, Ohio, United States
San Diego, California, United States
Kettering, Ohio, United States
Paris, , France
Brugge, , Belgium
Coeur D'alene, Idaho, United States
La Jolla, California, United States
Afula, , Israel
Singapore, , Singapore
Palo Alto, California, United States
Singapore, , Singapore
Louisville, Kentucky, United States
Haifa, , Israel
Houma, Louisiana, United States
Ottawa, Ontario, Canada
East Kilbride, , United Kingdom
Bangkok, , Thailand
San Diego, California, United States
Rozzano, , Italy
Phoenix, Arizona, United States
London, Ontario, Canada
Leeds, , United Kingdom
Mobile, Alabama, United States
Sarasota, Florida, United States
Chattanooga, Tennessee, United States
Saint Louis, Missouri, United States
Taipei, , Taiwan
Richmond, Indiana, United States
Edmonton, Alberta, Canada
Tupelo, Mississippi, United States
Ioannina, , Greece
Lincoln, , United Kingdom
Plymouth, , United Kingdom
Hobart, , Australia
Tacoma, Washington, United States
Zagreb, , Croatia
San Diego, California, United States
Moenchengladbach, , Germany
Davao, , Philippines
Manila, , Philippines
Winchester, Virginia, United States
Liege, , Belgium
Toulouse Cedex 9, , France
Bath, , United Kingdom
Middlesbrough, , United Kingdom
Haverhill, Massachusetts, United States
Lincoln, Nebraska, United States
Jamaica, New York, United States
Norfolk, Virginia, United States
Cambridge, Ontario, Canada
Langhorne, Pennsylvania, United States
Tokyo, , Japan
Eindhoven, , Netherlands
Newmarket, Ontario, Canada
Grand Blanc, Michigan, United States
Leicester, , United Kingdom
Berlin, , Germany
Atlanta, Georgia, United States
Hvidovre, , Denmark
Birmingham, , United Kingdom
Milano, , Italy
London, , United Kingdom
Osaka, , Japan
Little Rock, Arkansas, United States
Bytom, , Poland
Tokyo, , Japan
Baltimore, Maryland, United States
Taichung, , Taiwan
Utrecht, , Netherlands
Taipei, , Taiwan
Vienna, , Austria
Kuala Lumpur, , Malaysia
Edinburgh, , United Kingdom
Toronto, Ontario, Canada
Blackpool, , United Kingdom
Bruxelles, , Belgium
Brussels, , Belgium
Milano, , Italy
Haifa, , Israel
Rotterdam, , Netherlands
Venlo, , Netherlands
Gifu, , Japan
Erie, Pennsylvania, United States
Creteil, , France
Adelaide, , Australia
Sendai, , Japan
Bruxelles, , Belgium
Hampstead, , United Kingdom
Paris, , France
Bloemfontein, , South Africa
Kaohsiung, , Taiwan
Duesseldorf, , Germany
Seoul, , Korea, Republic Of
Taipei, , Taiwan
Nashville, Tennessee, United States
Muncie, Indiana, United States
Gainesville, Georgia, United States
Thessaloniki, , Greece
Philadelphia, Pennsylvania, United States
Paris, , France
Shanghai, , China
Beijing, , China
Viborg, , Denmark
Gurnee, Illinois, United States
Quebec, , Canada
Davao City, , Philippines
Seoul, , Korea, Republic Of
Pessac, , France
Rock Hill, South Carolina, United States
New Delhi, , India
Auckland, , New Zealand
Berlin, , Germany
Petah Tikva, , Israel
Tianjin, , China
Dudley, , United Kingdom
Tokushima, , Japan
Basel, , Switzerland
Camperdown, , Australia
Bucuresti, , Romania
Changsha, , China
Mobile, Alabama, United States
Littleton, Colorado, United States
Louisville, Kentucky, United States
Slidell, Louisiana, United States
Oklahoma City, Oklahoma, United States
Kuala Lumpur, , Malaysia
Bangkoknoi, , Thailand
Hefei, , China
Nanjing, , China
Gwangju, , Korea, Republic Of
Greensboro, North Carolina, United States
Sydney, , Australia
Kyoto, , Japan
Lublin, , Poland
Swansea, , United Kingdom
Beijing, , China
Quezon City, , Philippines
New Delhi, , India
Fort Wayne, Indiana, United States
Seoul, , Korea, Republic Of
Ube, , Japan
Sao Paulo, , Brazil
Pavia, , Italy
Ashkelon, , Israel
Palo Alto, California, United States
Sanford, North Carolina, United States
Brno, , Czechia
Praha 10, , Czechia
Milano, , Italy
Napoli, , Italy
Tokyo, , Japan
Tsu, , Japan
Deventer, , Netherlands
Santiago De Compostela, , Spain
Taoyuan County, , Taiwan
Genk, , Belgium
Gilbert, Arizona, United States
Berlin, , Germany
Brasschaat, , Belgium
Innsbruck, , Austria
Pecs, , Hungary
Mannheim, , Germany
Feldkirch, , Austria
Baguio City, , Philippines
Nis, , Serbia
Seoul, , Korea, Republic Of
Winnipeg, Manitoba, Canada
Lille Cedex, , France
Heraklion, , Greece
Berlin, , Germany
Gyor, , Hungary
Cordoba, , Argentina
Cordoba, , Argentina
Brasov, , Romania
Sao Paulo, , Brazil
Madrid, , Spain
Beijing, , China
Bielefeld, , Germany
Chengdu, , China
Hamburg, , Germany
Gabrovo, , Bulgaria
Cordoba, , Argentina
Hamilton, Ontario, Canada
Fukuoka, , Japan
Taunton, , United Kingdom
Bonheiden, , Belgium
Wynnewood, Pennsylvania, United States
Singapore, , Singapore
San Diego, California, United States
Leverkusen, , Germany
Newcastle Upon Tyne, , United Kingdom
Herston, , Australia
Wollongong, , Australia
Paris Cedex 14, , France
Pleven, , Bulgaria
Miskolc, , Hungary
Manila, , Philippines
Holbæk, , Denmark
Tallinn, , Estonia
Portsmouth, , United Kingdom
Olsztyn, , Poland
Jinan, , China
Hradec Kralove, , Czechia
Timisoara, , Romania
Kayseri, , Turkey
Bay City, Michigan, United States
Jerusalem, , Israel
Incheon, , Korea, Republic Of
San Juan, , Philippines
Kuala Lumpur, , Malaysia
Shanghai, , China
Tartu, , Estonia
Bucuresti, , Romania
Bialystok, , Poland
Everett, Washington, United States
Xi'an, Shaanxi, China
Wellington, Florida, United States
Brno, , Czechia
Liège, , Belgium
Salvador, , Brazil
Mainz, , Germany
Luedenscheid, , Germany
Taipei, , Taiwan
Worms, , Germany
Safed, , Israel
Lisboa, , Portugal
Amsterdam, , Netherlands
Harefield, , United Kingdom
Tokyo, , Japan
Gent, , Belgium
Springfield, Missouri, United States
Falls Church, Virginia, United States
Chambersburg, Pennsylvania, United States
Munster, Indiana, United States
Caen Cedex, , France
Woodville South, , Australia
Larissa, , Greece
Nieuwegein, , Netherlands
Wroclaw, , Poland
Graz, , Austria
Changchun, , China
El Paso, Texas, United States
Stevenage, , United Kingdom
New York, New York, United States
Sao Paulo, , Brazil
Marikina City, , Philippines
Seoul, , Korea, Republic Of
Montreal, Quebec, Canada
Amarillo, Texas, United States
Eindhoven, Brabant, Netherlands
Osaka, , Japan
Concord, , Australia
Mons, , Belgium
Porto Alegre, , Brazil
Guangzhou, , China
Lyon, , France
Springfield, Illinois, United States
Xuzhou, , China
Ede, , Netherlands
Vila Nova De Gaia, , Portugal
Helmond, , Netherlands
Zuerich, , Switzerland
Beersheba, , Israel
Busan, , Korea, Republic Of
Magdeburg, , Germany
Hamburg, , Germany
Fort Wayne, Indiana, United States
Basingstoke, , United Kingdom
Seoul, , Korea, Republic Of
Pancevo, , Serbia
Taipei, , Taiwan
Manila, , Philippines
Pune, , India
Riga, , Latvia
Phoenix, Arizona, United States
Gyeonggi Do, , Korea, Republic Of
Rosario, , Argentina
Tokyo, , Japan
Krapinske Toplice, , Croatia
Lipa City, , Philippines
Brasov, , Romania
Ciudad Autonoma De Buenos Aires, , Argentina
Krakow, , Poland
Roeselare, , Belgium
Chengdu, , China
Dortmund, , Germany
Linz, , Austria
Niska Banja, , Serbia
Dorchester, , United Kingdom
Saga, , Japan
Parma, , Italy
Raleigh, North Carolina, United States
Alexandria, Louisiana, United States
Salvador, , Brazil
Levis, Quebec, Canada
Nanjing, , China
Seoul, , Korea, Republic Of
Aguascalientes, , Mexico
Pasig City, , Philippines
Haifa, , Israel
Valhalla, New York, United States
Beijing, , China
Peoria, Illinois, United States
Amersfoort, , Netherlands
Gouda, Zuid Holland, Netherlands
Dubrovnik, , Croatia
Bruxelles, , Belgium
Milano, , Italy
Beijing, , China
Peterborough, , United Kingdom
Kurashiki, , Japan
Budapest, , Hungary
Northridge, California, United States
Somerset, New Jersey, United States
Clearwater, Florida, United States
Garran, , Australia
Busan, , Korea, Republic Of
New Taipei, , Taiwan
Londonderry, , United Kingdom
Almada, , Portugal
Fremont, California, United States
Suzhou, , China
Hiroshima, , Japan
Szekszárd, , Hungary
Birmingham, , United Kingdom
Dunedin, , New Zealand
Shanghai, , China
Sofia, , Bulgaria
Rotorua, , New Zealand
Beijing, , China
Murdoch, , Australia
Braga, , Portugal
Hanoi, , Vietnam
Cheongju Si, , Korea, Republic Of
Athens, , Greece
Jackson, Tennessee, United States
Bridgewater, New Jersey, United States
Belgrade, , Serbia
Edegem, , Belgium
Heerlen, , Netherlands
Clayton, , Australia
Debrecen, , Hungary
Szombathely, , Hungary
Chengdu, , China
Madrid, , Spain
Slagelse, , Denmark
Fukuoka Shi, , Japan
Kyoto Shi, , Japan
Daejeon, , Korea, Republic Of
Wonju, , Korea, Republic Of
Ostrava Poruba, , Czechia
Budapest, , Hungary
Columbus, Ohio, United States
Uzice, , Serbia
Bardejov, , Slovakia
Haifa, , Israel
Fukuoka, , Japan
Tauranga, , New Zealand
Fort Lauderdale, Florida, United States
Cordoba, , Argentina
La Plata, , Argentina
Salta, , Argentina
Villa Maria, , Argentina
Belo Horizonte, , Brazil
Slavonski Brod, , Croatia
Zalaegerszeg, , Hungary
Seoul, , Korea, Republic Of
Tijuana, , Mexico
Oswiecim, , Poland
Cape Town, , South Africa
Tokyo, , Japan
Rechovot, , Israel
Rijeka, , Croatia
Iloilo City, , Philippines
Torun, , Poland
Thessaloniki, , Greece
Turnhout, , Belgium
Seoul, , Korea, Republic Of
Rishon Lezion, , Israel
Saint Paul, Minnesota, United States
Trinity, Florida, United States
Shreveport, Louisiana, United States
Poughkeepsie, New York, United States
Cordoba, , Argentina
Hasselt, , Belgium
Peterborough, Ontario, Canada
Alkmaar, , Netherlands
Enschede, , Netherlands
Veldhoven, , Netherlands
Worcester, , South Africa
Beijing, , China
Poitiers, , France
Alexander City, Alabama, United States
Stamford, Connecticut, United States
Bangor, Maine, United States
Zhengzhou, , China
Greifswald, , Germany
Kecskemet, , Hungary
Bonn, , Germany
Belgrade, , Serbia
Cochin, , India
Busan, , Korea, Republic Of
Hazel Crest, Illinois, United States
Omaha, Nebraska, United States
Fort Lauderdale, Florida, United States
Chongqing, , China
Brno, , Czechia
Hangzhou, Zhejiang, China
Pulau Pinang, , Malaysia
Maastricht, , Netherlands
Talcahuano, , Chile
Remscheid, , Germany
Seriate, , Italy
Kaposvar, , Hungary
Angers, , France
Rostock, , Germany
Kaohsiung, , Taiwan
Daejeon, , Korea, Republic Of
Quezon, , Philippines
Targu Mures, , Romania
Nijmegen, , Netherlands
Pasadena, California, United States
Guiyang, , China
Cape Town, , South Africa
Florencio Varela, , Argentina
Singapore, , Singapore
Le Coudray, , France
Hanoi, , Vietnam
S Hertogenbosch, , Netherlands
Slany, , Czechia
Itabashi Ku, , Japan
Kragujevac, , Serbia
Izmir, , Turkey
Isleworth, , United Kingdom
Budapest, , Hungary
Dasmarinas, , Philippines
Madrid, , Spain
Madrid, , Spain
Valencia, , Spain
Wakayama, , Japan
Eskisehir, , Turkey
Malatya, , Turkey
Brandenburg An Der Havel, , Germany
Ankara, , Turkey
Bahia Blanca, , Argentina
Ballarat, , Australia
Elizabeth Vale, , Australia
Praha 2, , Czechia
Treviglio, , Italy
Riga, , Latvia
Oak Ridge, Tennessee, United States
Roma, , Italy
Tianjin, , China
Madrid, , Spain
Vilnius, , Lithuania
Kingswood, , Australia
Seoul, , Korea, Republic Of
Belgrade, , Serbia
Mersin, , Turkey
Barcelona, , Spain
Barcelona, , Spain
Caba, , Argentina
Barcelona, , Spain
Malaga, , Spain
Changhua, , Taiwan
Milano, , Italy
Wroclaw, , Poland
Lanzhou, , China
Plzen, , Czechia
Lugano, , Switzerland
Daugavpils, , Latvia
Minot, North Dakota, United States
Matthews, North Carolina, United States
Maastricht, Limburg, Netherlands
Votuporanga, , Brazil
Corbeil Essonnes Cedex, , France
Budapest, , Hungary
Budapest, , Hungary
Sremska Kamenica, , Serbia
Yokohama, , Japan
Roma, , Italy
Dongguan, , China
Yanji, , China
Deventer, Overijssel, Netherlands
Enschede, Overijssel, Netherlands
Guangzhou, , China
Englewood, New Jersey, United States
Tübingen, , Germany
Daegu, , Korea, Republic Of
Copenhagen S, , Denmark
Hastings, , New Zealand
Mangalore, , India
Blagoevgrad, , Bulgaria
Takamatsu, , Japan
Fuzhou, , China
Skierniewice, , Poland
Banska Bystrica, , Slovakia
Rosario, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Bydgoszcz, , Poland
Naleczow, , Poland
Svidnik, , Slovakia
Zilina, , Slovakia
Alicante, , Spain
Barcelona, , Spain
Manises, , Spain
Sao Paulo, , Brazil
Beijing, , China
Shinjuku Ku, , Japan
Campinas, , Brazil
Tatuí, , Brazil
Sofia, , Bulgaria
Rouen Cedex, , France
Budapest, , Hungary
Siauliai, , Lithuania
Leiria, , Portugal
Wenzhou, , China
Kumamoto City, , Japan
Nanjing, , China
Frankfurt, , Germany
Bergamo, , Italy
Liepaja, , Latvia
Miri, , Malaysia
Gyula, , Hungary
Trois Rivières, Quebec, Canada
Ceske Budejovice, , Czechia
Athens Attica, , Greece
Bergamo, , Italy
Taipei, , Taiwan
Cluj Napoca, , Romania
Bruxelles, , Belgium
Roma, , Italy
Torrette Di Ancona, , Italy
Aveiro, , Portugal
Bahia Blanca, , Argentina
Wien, , Austria
Belo Horizonte, , Brazil
São Paulo, , Brazil
Incheon, , Korea, Republic Of
Zutphen, , Netherlands
Madrid, , Spain
Vigo, , Spain
Sofia, , Bulgaria
Santo André, , Brazil
Surat, , India
Culiacan, , Mexico
Taipei City, , Taiwan
Sofia, , Bulgaria
Alessandria, , Italy
Sagamihara, , Japan
Valencia, , Spain
Zaragoza, , Spain
Muntinlupa, , Philippines
Herlev, , Denmark
Wroclaw, , Poland
Herning, , Denmark
Sopot, , Poland
Kingston Upon Thames, , United Kingdom
Passo Fundo, , Brazil
Santo Andre, , Brazil
Hangzhou, , China
Zagreb, , Croatia
Szekszárd, , Hungary
Patna, , India
Vijayawada, , India
Isehara, , Japan
Osaka Shi, , Japan
Lublin, , Poland
Guimarães, , Portugal
Santa Maria Da Feira, , Portugal
West Bromwich, , United Kingdom
Adelaide, , Australia
Meguro Ku, , Japan
Sremska Mitrovica, , Serbia
Seoul, , Korea, Republic Of
El Paso, Texas, United States
Lodz, , Poland
Naples, Florida, United States
Flint, Michigan, United States
Wuhan, , China
Rapid City, South Dakota, United States
Afyon, , Turkey
Tianjin, , China
Sao Paulo, , Brazil
Sherman, Texas, United States
Montpellier, , France
Manchester, , United Kingdom
Saitama, , Japan
Ciudad Autonoma De Buenos Aires, , Argentina
Hanoi, , Vietnam
Zunyi, , China
Jerusalem, , Israel
Southport, , Australia
Rosario, , Argentina
Birtinya, , Australia
Torquay, , United Kingdom
Hirosaki, , Japan
Shiwa Gun, , Japan
Centurion, , South Africa
Ashdod, , Israel
Lleida, , Spain
Krakow, , Poland
Chennai, , India
Milton, , Australia
Mexico, , Mexico
Chuncheon, , Korea, Republic Of
Mainz, , Germany
Botucatu, , Brazil
Santa Fe, , Argentina
Porto Alegre, , Brazil
Kisarazu Shi, , Japan
Tsuchiura City, , Japan
Tsukuba City, , Japan
Kitakyushu Shi, , Japan
Mar Del Plata, , Argentina
Shinagawa, , Japan
Pathum Wan, , Thailand
Hangzhou, , China
Ningbo, , China
Wałbrzych, , Poland
Amarillo, Texas, United States
Emmen, , Netherlands
Hangzhou, , China
Ciudad Autonoma Buenos Aires, , Argentina
Porto Alegre, , Brazil
Zabrze, , Poland
Ho Chi Minh, , Vietnam
Katowice, , Poland
Frankfurt, , Germany
Harderwijk, , Netherlands
Sremska Kamenica, , Serbia
Ha Noi, , Vietnam
Kochi, , Japan
Svendborg, , Denmark
El Paso, Texas, United States
Huizhou, , China
Ciudad Autonoma Buenos Aires, , Argentina
Hangzhou, , China
Tianjin, , China
Chicago, Illinois, United States
Ciudad Autonoma De Buenos Aires, , Argentina
São Paulo, , Brazil
Viña Del Mar, , Chile
Tiberias, , Israel
Stara Zagora, , Bulgaria
Belgrade, , Serbia
Athens, , Greece
Martin, , Slovakia
Queretaro, , Mexico
Fukui Shi, , Japan
Ureshino Shi, , Japan
Pamplona, , Spain
Nijmegen, , Netherlands
Somerset West, , South Africa
Koga, , Japan
Taipei, , Taiwan
Yangsan Si, , Korea, Republic Of
Porto Alegre, , Brazil
Jerusalem, , Israel
Siedlce, , Poland
Athens, , Greece
Kaunas, , Lithuania
Santa Fe, , Argentina
Fukuoka Shi, , Japan
Bad Nauheim, , Germany
Sao Bernardo Do Campo, , Brazil
Kfar Sava, , Israel
Kfar Sava, , Israel
Bratislava, , Slovakia
Tucson, Arizona, United States
Przemysl, , Poland
Kaohsiung, , Taiwan
Gunma, , Japan
Tokyo, , Japan
Goyang Si, , Korea, Republic Of
Cordoba, , Argentina
Exeter, , United Kingdom
Belgrade, , Serbia
Brezno, , Slovakia
Concepcion, , Chile
Athens, , Greece
London, , United Kingdom
Lille Cedex, , France
Ramat Gan, , Israel
Targu Mures, , Romania
Matsudo Shi, , Japan
Rio De Janeiro, , Brazil
Limoges, , France
Taichung, , Taiwan
Bucheon Si, , Korea, Republic Of
Kansas City, Missouri, United States
Toledo, Ohio, United States
Vila Real, , Portugal
Istanbul, , Turkey
Houston, Texas, United States
Cape Town, , South Africa
Sao Paulo, , Brazil
Warszawa, , Poland
Goiania, , Brazil
Ahmedabad, , India
Porto Alegre, , Brazil
Pleven, , Bulgaria
Kota Bahru, , Malaysia
Marilia, , Brazil
Porto Alegre, , Brazil
Belo Horizonte, , Brazil
Criciúma, , Brazil
New Orleans, Louisiana, United States
Sao Jose Do Rio Preto, , Brazil
Frederiksberg, , Denmark
Nagoya Shi, , Japan
Ribeirao Preto, , Brazil
Iasi, , Romania
Tg. Mures, , Romania
Timisoara, , Romania
Nishinomiya Shi, , Japan
Changzhou, , China
Hyderabad, , India
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Campina Grande Do Sul, , Brazil
Haskovo, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Zabok, , Croatia
ålborg, , Denmark
Alexandroupolis, , Greece
Amritsar, , India
Belgaum, , India
Hyderbad, , India
Ludhiana, , India
Mysore, , India
Naharya, , Israel
Chiba, , Japan
Himeji Shi, , Japan
Kasuga Shi, , Japan
Nagoya Shi, , Japan
Kota Bharu, , Malaysia
Seberang Jaya, , Malaysia
Otahuhu, , New Zealand
Cebu, , Philippines
Manila, , Philippines
Oradea, , Romania
Nai Mueang Subdistrict Mueang, , Thailand
Ho Chi Minh, , Vietnam
Ho Chi Minh, , Vietnam
Olsztyn, , Poland
Suita Shi, , Japan
La Tronche, , France
Cleveland, Ohio, United States
Lugano, Ticino, Switzerland
San Diego, California, United States
Birmingham, Alabama, United States
Huntsville, Alabama, United States
Scottsdale, Arizona, United States
Bakersfield, California, United States
Newport Beach, California, United States
Santa Monica, California, United States
Stockton, California, United States
Trumbull, Connecticut, United States
Jacksonville, Florida, United States
Loxahatchee Groves, Florida, United States
Orange, Florida, United States
Sarasota, Florida, United States
Cartersville, Georgia, United States
Gainesville, Georgia, United States
Elkhart, Indiana, United States
Salisbury, Maryland, United States
Saginaw, Michigan, United States
Saginaw, Michigan, United States
Duluth, Minnesota, United States
Bronx, New York, United States
Chapel Hill, North Carolina, United States
Lenoir, North Carolina, United States
Bartlesville, Oklahoma, United States
Tulsa, Oklahoma, United States
Greenville, South Carolina, United States
Kingwood, Texas, United States
Kyle, Texas, United States
Lubbock, Texas, United States
Sherman, Texas, United States
Leesburg, Virginia, United States
La Crosse, Wisconsin, United States
Ciudad Autonoma Buenos Aires, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Coronel Suarez, , Argentina
Junin, , Argentina
Quilmes, , Argentina
Rosario, , Argentina
Salta, , Argentina
Salta, , Argentina
San Martin, , Argentina
San Miguel De Tucuman, , Argentina
San Nicolas, , Argentina
Santa Fe, , Argentina
Venado Tuerto, , Argentina
Cairns, , Australia
Austria, , Austria
Braunau Am Inn, , Austria
Wiener Neustadt, , Austria
Mechelen, , Belgium
Mol, , Belgium
Belo Horizonte, , Brazil
Brasilia, , Brazil
Brasília, , Brazil
Campinas, , Brazil
Curitiba, , Brazil
Curitiba, , Brazil
Curitiba, , Brazil
Natal, , Brazil
Pelotas, , Brazil
Porto Alegre, , Brazil
Recife, , Brazil
Recife, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Sao Paulo, , Brazil
São Jose Do Rio Preto, , Brazil
São José, , Brazil
Uberaba, , Brazil
Vitória, , Brazil
Vitória, , Brazil
Burgas, , Bulgaria
Panagyurishte, , Bulgaria
Pernik, , Bulgaria
Plovdiv, , Bulgaria
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Calgary, Alberta, Canada
Vancouver, British Columbia, Canada
Moncton, New Brunswick, Canada
Newmarket, Ontario, Canada
Oakville, Ontario, Canada
Windsor, Ontario, Canada
St Jean Sur Richelieu, Quebec, Canada
Terrebonne, Quebec, Canada
Quebec, , Canada
Quebec, , Canada
Puerto Varas, , Chile
Santiago, , Chile
Temuco, , Chile
Temuco, , Chile
Baotou, , China
Dongguan, , China
Guiyang, , China
Jinan, , China
Jining, , China
Nanchang, , China
Nanjing, , China
Shenzhen, , China
Su Zhou, , China
Taiyuan, , China
Wenzhou, , China
Wuhan, , China
Wulumuqi, , China
Yichang, , China
Yinchuan, , China
Cakovec, , Croatia
Jihlava, , Czechia
Kolin, , Czechia
Liberec, , Czechia
Ostrava, , Czechia
Pardubice, , Czechia
Prague, , Czechia
Prague, , Czechia
Praha 2, , Czechia
Praha 4, , Czechia
Trinec, , Czechia
Aahus N, , Denmark
Koge, , Denmark
Chambray Les Tours, , France
Dijon Cedex, , France
Nice Cedex 1, , France
Nîmes Cedex 9, , France
Poitiers, , France
Rouen, , France
Vandoeuvre Les Nancy Cedex, , France
Versailles Cedex, , France
Bad Friedrichshall, , Germany
Bad Krozingen, , Germany
Bitburg, , Germany
Bonn Beuel, , Germany
Bremen, , Germany
Coburg, , Germany
Dresden, , Germany
Erfurt, , Germany
Hamburg, , Germany
Ludwigshafen, , Germany
Mainz, , Germany
Neuwied, , Germany
Worms, , Germany
Athens, , Greece
Athens, , Greece
Patra, , Greece
Thessaloniki, , Greece
Szeged, , Hungary
Szolnok, , Hungary
Aligarh, , India
Bangalore, , India
Bangalore, , India
Delhi, , India
Faridabad, , India
Kolkata, , India
Kolkata, , India
Kolkata, , India
Mumbai, , India
Nagpur, , India
Nagpur, , India
Nagpur, , India
Pune, , India
Shimoga, , India
Ulhasnagar, , India
Bologna, , Italy
Chieti, , Italy
La Spezia, , Italy
Mestre, , Italy
Pisa, , Italy
Sassari, , Italy
Tradate, , Italy
Treviso, , Italy
Aichi, , Japan
Ishikawa, , Japan
Kanagawa, , Japan
Kumamoto Shi, , Japan
Kure Shi, , Japan
Matsumoto Shi, , Japan
Minato Ku, , Japan
Miyazaki Shi, , Japan
Nagano Shi, , Japan
Nagoya Shi, , Japan
Okayama Shi, , Japan
Urayasu Shi, , Japan
Gangseo Gu, , Korea, Republic Of
Sejong Si, , Korea, Republic Of
Kaunas, , Lithuania
Klaipeda, , Lithuania
Panevezys, , Lithuania
Kota Kinabalu, , Malaysia
Kuching, , Malaysia
Selayang, , Malaysia
Guadalajara, , Mexico
Jalapa, , Mexico
Mazatlan, , Mexico
Monterrey, , Mexico
San Luis Potosí, , Mexico
Torreon, , Mexico
Xalapa, , Mexico
Almelo, , Netherlands
Den Haag, , Netherlands
Goes, , Netherlands
Roermond, , Netherlands
Auckland, , New Zealand
Christchurch, , New Zealand
New Plymouth, , New Zealand
Angeles, , Philippines
Davao City, Davao Del Sur, , Philippines
Ilocos Sur, , Philippines
Iloilo, , Philippines
Elbląg, , Poland
Kielce, , Poland
Krakow, , Poland
Ostrowiec Swietokrzyski, , Poland
Poznan, , Poland
Przemysl, , Poland
Warszawa, , Poland
Coimbra, , Portugal
Covilha, , Portugal
Lisbon, , Portugal
Baia Mare, , Romania
Bucharest, , Romania
Bucuresti, , Romania
Bucuresti, , Romania
Bucuresti, , Romania
Cluj Napoca, , Romania
Cluj Napoca, , Romania
Constanta, , Romania
Craiova, , Romania
Pitesti, , Romania
Timisoara, , Romania
Smederevo, , Serbia
Zajecar, , Serbia
Kosice, , Slovakia
Kosice, , Slovakia
Košice, , Slovakia
Lucenec, , Slovakia
Moldava Nad Bodvou, , Slovakia
Nitra, , Slovakia
Nove Zamky, , Slovakia
Presov, , Slovakia
Zvolen, , Slovakia
Cape Town, , South Africa
Durban, , South Africa
Johannesburg, , South Africa
Somerset West, , South Africa
El Palmar, , Spain
Gijon, , Spain
Madrid, , Spain
Tarragona, , Spain
Chiangmai, , Thailand
Adana, , Turkey
Ankara, , Turkey
Ankara, , Turkey
Antalya, , Turkey
Bursa, , Turkey
Istanbul, , Turkey
Kutahya, , Turkey
Samsun, , Turkey
Bristol, , United Kingdom
Swansea, , United Kingdom
Wigan, , United Kingdom
Yeovil, , United Kingdom
Hanoi, , Vietnam
Ho Chi Minh, , Vietnam
Rockville, Maryland, United States
Columbia, Missouri, United States
Cordoba, , Argentina
Zhanjiang, , China
Kolkata, , India
Chikushino Shi, , Japan
Saitama Shi, , Japan
Leiderdorp, , Netherlands
New Taipei, , Taiwan
Hanoi, , Vietnam
Fort Worth, Texas, United States
Chicago, Illinois, United States
Linfen, , China
Xinxiang, , China
Tampa, Florida, United States
West Monroe, Louisiana, United States
Porto Alegre, , Brazil
Sao Jose Do Rio Preto, , Brazil
Sarasota, Florida, United States
La Tronche, , France
Bronx, New York, United States
Redding, California, United States
Springfield, Ohio, United States
Hialeah, Florida, United States
Birmingham, Alabama, United States
Safety Harbor, Florida, United States
Bydgoszcz, , Poland
Sao Paulo, , Brazil
Danbury, Connecticut, United States
Jacksonville, Florida, United States
Pomona, New Jersey, United States
Campinas, , Brazil
Amagasaki Shi, , Japan
Palos Hills, Illinois, United States
Porto Alegre, , Brazil
Traralgon, , Australia
Jacksonville, Florida, United States
Duluth, Minnesota, United States
Buffalo, New York, United States
Surrey, British Columbia, Canada
Kamogawa, , Japan
Kanazawa Shi, , Japan
Sneek, , Netherlands
Wuxi, , China
Seoul, , Korea, Republic Of
Lisboa, , Portugal
New York, New York, United States
Belgaum, , India
Mobile, Alabama, United States
Tomball, Texas, United States
Brasilia, , Brazil
Pelotas, , Brazil
Nanyang, , China
Nagpur, , India
Okayama Shi, , Japan
Tsukuba Shi, , Japan
Harrisburg, Pennsylvania, United States
Lanham, Maryland, United States
Natal, , Brazil
Wuhan, , China
Tokyo, , Japan
Roosendaal, , Netherlands
Sejong Si, , Korea, Republic Of
Yangsan Si, , Korea, Republic Of
Shantou, , China
Bikaner, , India
Nashville, Tennessee, United States
Recife, , Brazil
Wenzhou, , China
Hiratsuka Shi, , Japan
Toyama Shi, , Japan
Tiel, , Netherlands
Aveiro, , Portugal
Santa Rosa, California, United States
Xian, , China
Roma, , Italy
Changzhou, , China
Rouen Cedex, , France
Vila Nova De Gaia, , Portugal
North Miami Beach, Florida, United States
Thomasville, Georgia, United States
Zhongshan, , China
Pau Cedex, , France
Vandoeuvre Les Nancy Cedex, , France
Chieti, , Italy
Amagasaki Shi, , Japan
Izunokuni Shi, , Japan
Bucharest, , Romania
Bern, , Switzerland
Tainan, , Taiwan
Yokohama, , Japan
Sao Paulo, , Brazil
Chiba, , Japan
Itabashi Ku, , Japan
Chengdu, , China
Tokyo, , Japan
Busan, , Korea, Republic Of
Seoul, , Korea, Republic Of
Torun, , Poland
Criciúma, , Brazil
Ribeirao Preto, , Brazil
Santa Rosa, California, United States
Hialeah, Florida, United States
Pembroke Pines, Florida, United States
Curitiba, , Brazil
Curitiba, , Brazil
Santiago, , Chile
Viña Del Mar, , Chile
Guiyang, , China
Wenzhou, , China
Zhongshan, , China
Sesto San Giovanni, , Italy
Belgrade, , Serbia
Geneve 14, , Switzerland
Tainan, , Taiwan
Wakayama, , Japan
Vishakhapatnam, , India
Lansing, Michigan, United States
Jackson, Mississippi, United States
Houston, Texas, United States
Porto Alegre, , Brazil
Sao Paulo, , Brazil
Vina Del Mar, , Chile
Mulhouse Cedex, , France
Yilan County, , Taiwan
Shanghai, , China
Sendai, , Japan
Dongguan, , China
Chennai, , India
Miami, Florida, United States
Poços De Caldas, , Brazil
Salvador, , Brazil
Vitoria, , Brazil
Wuhan, , China
Ceske Budejovice, , Czechia
Pardubice, , Czechia
Budapest, , Hungary
Whangarei, , New Zealand
Przemysl, , Poland
Karabuk, , Turkey
Barcelona, , Spain
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Sao Paulo, , Brazil
Tokyo, , Japan
Manila, , Philippines
Guimaraes, , Portugal
Birmingham, Alabama, United States
Boca Raton, Florida, United States
Cary, North Carolina, United States
Zalaegerszeg, , Hungary
Jerusalem, , Israel
Barcelona, , Spain
Malaga, , Spain
Montpellier, , France
Matsudo Shi, , Japan
Mumbai, , India
Tacoma, Washington, United States
Belo Horizonte, , Brazil
Kamogawa, , Japan
Saitama Shi, , Japan
Urayasu Shi, , Japan
Gyeonggi Do, , Korea, Republic Of
Seoul, , Korea, Republic Of
Brick, New Jersey, United States
Overland Park, Kansas, United States
Bloomfield Hills, Michigan, United States
Belo Horizonte, , Brazil
Potigny, , France
Surat, , India
San Luis Potosí, , Mexico
Wroclaw, , Poland
Mossel Bay, , South Africa
Bialystok, , Poland
Bahia Blanca, , Argentina
Gainesville, Florida, United States
High Point, North Carolina, United States
Bethlehem, Pennsylvania, United States
Brasilia, , Brazil
St Catharines, Ontario, Canada
Xalapa, , Mexico
Singapore, , Singapore
Torun, , Poland
Guimaraes, , Portugal
Jackson, Michigan, United States
Greenville, South Carolina, United States
Humble, Texas, United States
Sao Paulo, , Brazil
Nantes Cedex 1, , France
Strasbourg, , France
Ferrara, , Italy
Gangseo Gu, , Korea, Republic Of
Coimbra, , Portugal
Tetovo, , North Macedonia
Sao Jose Do Rio Preto, , Brazil
Cavite, , Philippines
Mandaluyong, , Philippines
Tokyo, , Japan
Chicago, Illinois, United States
Halifax, Nova Scotia, Canada
Athens, , Greece
Skopje, , North Macedonia
Davao City, , Philippines
Coimbra, , Portugal
Hangzhou, , China
Wroclaw, , Poland
Walbrzych, , Poland
Olsztyn, , Poland
Lublin, , Poland
Downers Grove, Illinois, United States
Sta Rosa, , Philippines
Bytom, , Poland
Elblag, , Poland
Krakow, , Poland
Poznan, , Poland
Sopot, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Nishinomiya Shi, , Japan
Shinagawa, , Japan
Angers, , France
Wien, , Austria
Chiba, , Japan
Ho Chi Minh, , Vietnam
Greenville, South Carolina, United States
Athens, , Greece
Szolnok, , Hungary
Chesterfield, Missouri, United States
Prague, , Czechia
Chiba, , Japan
Warszawa, , Poland
Patients applied
Trial Officials
Janssen Research & Development, LLC Clinical Trial
Study Director
Janssen Research & Development, LLC
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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