Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery

Launched by POITIERS UNIVERSITY HOSPITAL · Feb 23, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at different ways to give an antibiotic called cefoxitin to help prevent infections after colorectal surgery. The study compares two methods: one involves giving a large dose of cefoxitin at the start, followed by a steady drip of the medication, while the other method uses smaller doses given at intervals. The main goal is to see if the first method is better at reducing the risk of surgical site infections (SSIs) within 30 days after surgery.

To participate in this trial, adult patients aged 18 and older who are scheduled for colorectal surgery lasting more than 90 minutes may be eligible. However, individuals with specific health issues, such as allergies to cefoxitin, severe obesity, or significant kidney problems, cannot join. If you decide to participate, you can expect careful monitoring and support throughout the study, which aims to improve care for patients undergoing this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (≥18 years)
• • Undergoing colorectal surgery (predictable duration \> 90 min)
• Exclusion Criteria:
• • Patients with known history of hypersensitivity to cefoxitin or others beta-lactams
• • Patients with extreme severe obesity (defined by a body mass index greater than 50 kg/m2)
• • Patients with severe renal insufficiency (clearance creatinine \< 30ml/min)
• • Active bacterial infection at the time of surgery or recent antimicrobial therapy (up to 2 weeks before surgery) except for oral surgical antibiotic prophylaxis