PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism

Launched by UNIVERSITY OF CALGARY · Feb 21, 2023

Keywords

ClinConnect Summary

The PREP and GO study is a clinical trial designed to look at how anticoagulation (blood-thinning) treatments are managed for women during pregnancy, especially around the time of labor and after giving birth. This study is important because it aims to find the best ways to prevent blood clots, which can be a serious concern for pregnant women. The trial is currently recruiting participants who are 18 years or older and need anticoagulation therapy due to confirmed blood clots or certain blood disorders.

If you or someone you know is pregnant and has had blood clots in the past or has a condition that requires blood thinners, you might be eligible to participate. This study will involve monitoring participants as they go through labor and the postpartum period, helping researchers understand the best practices for managing anticoagulation during this time. Participants will receive guidance and support throughout the study, and their experiences will contribute to improving care for future pregnant women at risk of blood clots.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• * Requires anticoagulation during the antepartum period of pregnancy for a VTE indication, including at least one of:
• • 1. Objectively confirmed VTE (DVT, superficial vein thrombosis \[SVT\], PE or unusual site thrombosis) diagnosed during the current pregnancy;
• • 2. Objectively confirmed VTE diagnosed in a prior pregnancy;
• • 3. Objectively confirmed VTE diagnosed when not pregnant;
• • 4. Inherited or acquired thrombophilia requiring anticoagulation.
• • Receiving any dose or type of LMWH during the antepartum period
• Exclusion Criteria:
• • Anticoagulation for a non-VTE indication, including prosthetic heart valves, atrial fibrillation, prevention of placenta-mediated pregnancy complications, or prevention of recurrent pregnancy loss (participants can be included with a diagnosis of antiphospholipid syndrome (APS) with or without thrombotic events)
• • Unable to provide or declined consent.
• • Home or birthing centre planned delivery.