The Long-term Consequences of Neonatal Encephalopathy in the Hypothermia Era

Launched by MCGILL UNIVERSITY HEALTH CENTRE/RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE · Feb 23, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how children who experienced neonatal encephalopathy (a type of brain injury that can happen at birth) and received therapeutic hypothermia (a cooling treatment) are doing by the time they are 9 years old. The researchers want to understand how these children compare to their peers without any brain injuries in areas like thinking skills, attention, social interactions, and behavior. They will also examine the brain structure and health of both groups through MRI scans to see if there are any differences that might explain their development.

To be eligible for this study, children need to have been born between 2014 and 2018 and received specific cooling treatment shortly after birth for their brain injury. This trial is not yet recruiting participants, but when it does, children can expect to visit the study site for evaluations and a brain scan. Parents will also have the chance to fill out questionnaires to share their observations about their child's development. Overall, this study aims to gather important information that could help understand the long-term effects of neonatal encephalopathy and improve care for affected children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • born between 2014 and 2018
• • received whole-body cooling to an esophageal temperature of 33.5°C initiated within the first 6 hours of life, continued for 72 hours, and then they were slowly rewarmed received TH for moderate or severe NE
• Exclusion Criteria:
• • Participants with a history of
• • congenital infections
• • genetic or metabolic disorders
• • major brain malformations (e.g., lissencephaly) and
• • any contraindication for MRI (e.g., metal implant, claustrophobia)