Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

Launched by BAPTIST HEALTH SOUTH FLORIDA · Feb 24, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding glioblastoma, a type of aggressive brain tumor, by examining tissue collected during surgery. Researchers want to gather samples from different parts of the tumor and blood from participants to study how the tumor’s structure and genetic information vary. This research aims to uncover new insights about glioblastoma, which could lead to better treatment options in the future.

To participate in this study, you need to be at least 18 years old and have been diagnosed with glioblastoma or gliosarcoma. You should also have a specific type of brain scan that shows the tumor. If you decide to join, you will be asked to sign a consent form and will undergo standard surgery. The information collected from your tumor and blood will help scientists learn more about this challenging condition and potentially improve therapies for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Have the appearance of high-grade glioma on magnetic resonance (MR) imaging if allowed to consent and will undergo the procedure if the frozen is consistent with glioblastoma or gliosarcoma OR Patients with a history of histologically confirmed diagnosis of World Health Organization Grade glioblastoma or gliosarcoma that are undergoing repeat resection of a recurrent tumor as identified on preoperative MR imaging
• • 2. Aged ≥ 18 years old
• • 3. Contrast-enhancing tumor volume of at least 10 cc on the preoperative, volumetric MRI within 1 month prior to surgery
• • 4. Provision of signed and dated informed consent form by participant or legally authorized representative (LAR), if applicable
• Exclusion Criteria:
• • 1. Has a history or current evidence of any medical condition, therapy, or laboratory abnormality that might confound the results of the study or is not in the best interest of the participant, in the opinion of the treating investigator.