Effect of MgSO4 Pretreatment on Muscle Relaxation

Launched by ASSIUT UNIVERSITY · Mar 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how magnesium sulfate (a type of mineral) affects muscle relaxation during certain surgeries. Specifically, the researchers want to see if giving magnesium sulfate before surgery helps muscles relax faster and for a longer time when a drug called cis-atracurium is used. There are two groups in the study: one will receive magnesium sulfate, and the other will not.

To participate, you must be between 18 and 60 years old, scheduled for elective ear, nose, or throat surgery, and have a healthy weight. You cannot have any medical conditions that affect muscle activity or have certain allergies. If you choose to take part, you’ll receive either the magnesium sulfate or a placebo (a substance with no active ingredients), and the team will monitor how your muscles respond during the procedure. This trial is currently recruiting participants, and it aims to improve the care and comfort of patients undergoing surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age group 18-60 years old
• • Both genders
• • Patients who will be scheduled to undergo elective otorhinolaryngological surgery.
• • Patients with BMI between 18.5 and 24.9 Kg/m2.
• • Patients with American Society of Anesthesiologist physical status classification of 1 or 2
• Exclusion Criteria:
• • Patients who are less than 18 years old or more than 60 years old.
• • Patients on medications that interfered with muscle activity.
• • Allergy to medications used in this study.
• • Pregnancy or suspected pregnancy.
• • Neuro-muscular diseases.
• • Renal or hepatic impairment.
• • Hypermagnesemia (\>2.5 mmol) or hypomagnesemia (\<1.7 mmol).
• • Patients refusing to study