Non-specific Effects of a Modified Measles Vaccination Schedule to Prevent Allergy and Unrelated Infection in Children

Launched by LAURE PITTET, MD-PHD · Feb 24, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how the measles-mumps-rubella (MMR) vaccine might help protect children from allergies and infections, even those not directly related to measles. Researchers want to see if changing the timing of the vaccine could have additional benefits for children's health. The trial is currently recruiting participants, specifically healthy children who are 6 months old and have received their vaccinations according to the Swiss vaccination schedule.

To participate, children must be in good health and have received at least two doses of a particular vaccine, with the last dose given at least two weeks before joining the study. Unfortunately, children with specific health issues or allergies to the vaccine components cannot take part. Parents of eligible children can expect to be involved in the study process, which may include monitoring their child's health over time. This research is important as it could provide new insights into how vaccines can offer broader health benefits for children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Informed Consent as documented by signature
• • 2. 6-month-old children
• • 3. In overall good health, without any clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) and no clinically significant abnormal finding on history and/or physical examination
• • 4. Fully immunised for age according to the Swiss vaccination schedule
• • 1. with at least 2 doses of DTP-containing vaccine
• • 2. the last dose of vaccine received at least 2 weeks prior to enrolment
• Exclusion Criteria:
• • 1. Contra-indications to MMR, including
• • 1. immunosuppression (i.e. proven, suspected, or planned)
• • 2. allergy to a component of the vaccine
• • 3. receipt of a live-attenuated vaccine in the four weeks prior to inclusion
• • 2. Vaccine refusal
• • 3. Indication for an early MMR vaccination, including
• • 1. Measles outbreak
• • 2. Planned immunosuppression (indication to an accelerated schedule to be completed before starting an immunosuppressive treatment)
• • 3. Travel to a region with a high risk of measles outbreak
• • 4. Indication for vaccination with MMR-varicella (MMRV) instead of MMR, including
• • 1. severe eczema
• • 2. parental will
• • 5. Parental inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, known/suspected non-compliance, substance abuse, etc.
• • 6. Plan to move out of the country or have prolong absence during the trial
• • 7. Other sibling included in the trial (in the case of multiple pregnancy, only one child can be randomised)
• • 8. Any temporary contra-indication to MMR, including child being sick (active significant illness, inclusion can be delayed a few days until the illness resolves)