OCT Vibrography for Biomechanical Properties of Tissues

Launched by MASSACHUSETTS GENERAL HOSPITAL · Feb 26, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new tool called OCT Vibrography, which is designed to measure the mechanical properties of human tissues, like the cornea in the eye, skin, and gums. The goal is to see how well this technology works in understanding the health and condition of these tissues without needing invasive procedures.

To participate in the trial, you need to be between 18 and 75 years old and generally healthy. There are specific groups for people with healthy eyes, skin, and gums, as well as a group for those with a mild or moderate eye condition called keratoconus. Participants can expect to undergo some tests using the OCT Vibrography, which is non-invasive and safe. It's important to note that certain health conditions or previous surgeries may prevent someone from joining the study. If you think you might be eligible or are interested in learning more, please reach out!

Gender

ALL

Eligibility criteria

• Group 1:
• Inclusion criteria:
• • • Subjects with healthy eyes (age 18 - 75, N = 50)
• Exclusion criteria:
• • Subjects with history of eye diseases, and previous eye surgeries.
• • Subjects with diabetes, glaucoma family history
• • Subjects allergic to anesthetic eyedrop, especially proparacaine
• • Subjects with severe allergy
• • Subjects who have difficulty biting
• • Subjects who have recurrent corneal erosion
• Group 2:
• Inclusion criteria:
• • • Subjects with healthy skin (age 18 - 75, N = 10)
• Exclusion criteria:
• • • Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition
• Group 3:
• Inclusion criteria:
• • • Subjects with healthy gingiva (age 18 - 75, N = 10)
• Exclusion criteria:
• • • Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition
• Group 4:
• Inclusion criteria:
• • • Mild or moderate keratoconus subjects (age 18 - 40, N = 20)
• Exclusion criteria:
• • • Subjects with K-max above 60 diopters (Pentacam imaging) are excluded