Oropharyngeal Candidiasis (OPC) and S-ECC

Launched by TEMPLE UNIVERSITY · Feb 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at the connection between early oral thrush (a type of Candida infection) in young children and the development of severe tooth decay, known as severe early childhood caries (S-ECC). The researchers want to understand if having oral thrush in the first year of life affects how severe tooth decay might become later on.

To be part of the study, children must be between 9 to 15 months old and have at least one tooth that has fully grown in. The trial will include both children who have had oral thrush and those who have not, with 35 participants in each group. Parents or guardians will need to give their consent for their child to participate. Children with certain medical conditions, dental problems, or who have recently taken antibiotics will not be eligible to join. Participants can expect to help researchers learn more about these conditions, which could lead to better dental care for kids in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female individuals at the age of 9-24-month-old
• • Must have at least one fully erupted tooth at baseline visit
• • Parent/guardian willing and able to provide informed consent
• • With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)
• Exclusion Criteria:
• • Presence of a systemic medical condition (e.g. Down syndrome etc.)
• • Presence of an orofacial deformity
• • Presence of dental caries
• • Use of systemic antimicrobial therapy within 30 days of the baseline visit
• • Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.