Glycemic Control, Type II Diabetes, Parathyroidectomy

Launched by THE CLEVELAND CLINIC · Feb 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how surgery to remove the parathyroid glands (a procedure called parathyroidectomy) affects blood sugar control in patients who have both primary hyperparathyroidism and type 2 diabetes. The researchers want to understand if this surgery can help improve diabetes management in these patients. The trial is currently looking for participants aged 18 and older, including those who will have the surgery and those who will not.

To join the study, participants must have both conditions, but not everyone will qualify. For example, patients with a history of recurring parathyroid problems or those with type 1 diabetes cannot participate. Those who take part in the study will be monitored to see how their diabetes responds to the surgery and how their overall health changes. This research aims to provide valuable insights into the connection between these two health issues and how treatment can improve patient outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Study group: Consecutive patients older than 18 years old with concomitant PHPT and DM who will undergo PTX. The indications and need for surgery will be independent from the research team.
• • 2. Control group: Consecutive patients older than 18 years old with concomitant PHPT and DM who will not undergo PTX. The indications to forgo surgery will be independent from the research team.
• Exclusion Criteria:
• • 1. Patients with recurrent or persistent PHPT will not be included.
• • 2. Patients who are included but have evidence of recurrent or persistent PHPT based on six-month laboratory workup will be excluded from the final analysis (\<5% expected)9.
• • 3. Patients with type 1 diabetes mellitus
• • 4. Patients with secondary and/or tertiary hyperparathyroidism