Oxygen Toxicity: Mechanisms in Humans

Launched by DUKE UNIVERSITY · Feb 27, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Oxygen Toxicity: Mechanisms in Humans," is focused on understanding how certain factors can affect the risk of oxygen toxicity in scuba divers. Researchers want to learn how training the muscles we use to breathe, environmental conditions like lack of sleep and exposure to carbon dioxide, and being underwater may influence this risk. By studying these factors, the trial aims to improve our understanding of how oxygen toxicity can occur and what can be done to prevent it.

To participate, you must be a healthy adult aged 18 to 45, with equal numbers of men and women included. Participants will need to complete a health screening, engage in regular breathing exercises, and perform workouts both on land and underwater, sometimes while experiencing factors like sleep deprivation or carbon dioxide exposure. The researchers will compare how participants perform and breathe before and after these activities to see if there are any changes. If you're interested in learning more about how your body responds to different conditions while diving, this trial might be a great opportunity!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Equal numbers of male and female
• • Non-smokers
• • Aged 18-45 years
• • Males will be required to have VO2 peak \> or equal to mL/kg min
• • and females \> or equal to 30 mL/kg min
• Exclusion Criteria:
• • Pregnancy
• • Cardiorespiratory disease, including hypertension
• • Neuromuscular disease
• • Anemia
• • History of hemoglobinopathy, including sick cell disease and trait