Prehospital Inhaled Methoxyflurane Non-Clinical Occupational Exposure Study

Launched by OTTAWA HOSPITAL RESEARCH INSTITUTE · Mar 2, 2023

Keywords

ClinConnect Summary

Background:

Pain is a common emergency that is responsible for approximately 40% of ambulance calls.1 Effective and safe relief of acute pain is not only an important medical problem; since 2004, it is has been considered a fundamental human right.2 Yet, it is often undertreated in both prehospital and emergency department (ED) settings.3,4 Unrelieved pain activates the pituitary-adrenal axis, which can suppress the immune system and result in infection and poor wound healing. 5 Sympathetic activation can have negative effects on the cardiovascular, gastrointestinal, and renal systems, pre...

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Eligibility criteria

• Inclusion Criteria:
• • Patients ≥ 18 years of age
• Exclusion Criteria:
• • previous history of significant liver disease (e.g. Cirrhosis) or lab values outside normal range \*;
• • cardiac or respiratory illnesses (e.g. ischemic heart disease, asthma, chronic obstructive pulmonary disease/smoking hx \>10 pack per year history);
• • any renal impairment or lab values outside normal \*;
• • previous possible allergy to methoxyflurane by the patient or a
• • drug interactions: concurrent use of any potential nephrotoxic drugs relative; (aminoglycosidese.g. gentamicin), colistin, polymyxin B, amphotericin B, and tetracyclines);
• • personal or family history of malignant hyperthermia;
• • inclusion in another study not allowing the co-enrollment;
• • pregnancy or breastfeeding;
• • and history of use of methoxyflurane in the last 3 months.
• • normal laboratory values will be determined based on The Ottawa Hospital's available reference ranges.