Macrophage Programing in Acute Lung Injury: MiniBAL

Launched by WILLIAMJANSSEN · Mar 2, 2023

Keywords

ClinConnect Summary

This clinical trial, called MiniBAL, is studying how certain white blood cells, known as macrophages, respond to inflammation in the lungs of people with Acute Respiratory Distress Syndrome (ARDS) and Ventilator-Associated Pneumonia (VAP). The researchers want to understand how the immune system reacts to different types of lung injuries and whether testing lung cell samples more often can help doctors start treatment for infections faster. This trial is important because it could help improve care for patients on mechanical ventilators in the intensive care unit (ICU).

To be eligible for this trial, participants need to be adults aged 18-85 who are in the ICU and require a breathing machine, either because of ARDS or other reasons. Participants can expect to have a small amount of fluid taken from their lungs and some blood samples collected over a period of about 10 days. Additionally, nasal samples will be taken, and doctors will monitor their health closely. If any bacteria are found in the lung fluid, the participant’s doctor may start antibiotic treatment if needed. After leaving the hospital, participants might receive a follow-up call from the research team to check on their recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written informed consent (by LAR if subject unconscious or has altered mental status) prior to any study procedures. Verbal consent may be used as necessary
• • Adults between ages 18 and 85 years ikd
• • Admission to the intensive care unit.
• • Orally/nasally intubated or expected to be intubated within 48 hours
• Exclusion Criteria:
• • History of solid organ or bone marrow transplantation
• • Severe or massive hemoptysis
• • At significant risk for bleeding (INR \> 3 or PTT \> 3x normal)
• • Presence of pneumomediastinum or pneumothorax on recent imaging
• • Presence of an advanced directive with Do Not Intubate (DNI) status (Do Not Resuscitate (DNR) is acceptable)
• • Morbid state or expected to survive less than 24 hours because of an advanced co-morbid medical condition in the opinion of the PI and/or clinical team and attending physician.
• • Pregnancy