Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MV

Launched by WUHAN UNION HOSPITAL, CHINA · Mar 12, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a medication called levosimendan in patients suffering from Acute Respiratory Distress Syndrome (ARDS) who also have problems with the right side of their heart, known as right ventricular dysfunction (RVD). ARDS can make it hard to breathe, and when it affects the heart, it can become more serious. The study aims to see if levosimendan can improve heart function in these patients while they are on mechanical ventilation, a machine that helps them breathe. To do this, doctors will use a special ultrasound called transesophageal echocardiography, which provides a clearer view of the heart compared to standard methods.

To be eligible for this trial, participants must be between 18 and 80 years old, agree to take part, and have ARDS requiring mechanical ventilation along with acute RVD. However, certain individuals, such as those who are pregnant, have chronic heart issues, or are dealing with severe kidney or liver problems, will not be able to participate. If eligible, participants can expect to be closely monitored for how their heart responds to the treatment and any potential changes in their overall health. This study is crucial because it could lead to new ways to help patients with serious heart and lung conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who agree to participate in this clinical trial and sign informed consent
• • Age 18-80 years old, gender unlimited
• • Patients with ARDS(According to the diagnostic criteria of ARDS in Berlin 2012) requiring mechanical ventilation; Acute right ventricular dysfunction due to ARDS
• Exclusion Criteria:
• • Pregnant or lactating women;
• • Chronic cardiac insufficiency, pulmonary hypertension and/or right ventricular enlargement caused by chronic cardiopulmonary disease, cardiogenic shock or after major cardiac surgery before ARDS;
• • right ventricular myocardial infarction;
• • Uncorrected hypotension, hypoxemia and hypercapnia, or acid-base balance disturbance
• • Mechanical ventilation driving pressure \>=18cmH2O before randomization
• • Rapid arrhythmia;
• • pericardial tamponade;
• • Pulmonary embolism;
• • severe renal insufficiency;
• • severe liver insufficiency;
• • Failure to sign informed consent;
• • known allergy to the test drug and control drug;
• • Patients who have participated in other clinical trials within 30 days