Impact of Rotational Atherectomy on Coronary Microcirculation

Launched by LITHUANIAN UNIVERSITY OF HEALTH SCIENCES · Mar 5, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatments for patients with a specific type of heart condition called stable angina, which is often caused by narrowed or hardened arteries. The study is comparing a procedure called rotational atherectomy, which helps to remove calcium buildup in the arteries, to conventional stenting, where a small mesh tube is placed in the artery to keep it open. Researchers want to see how these treatments affect the tiny blood vessels in the heart, known as coronary microcirculation, both before and after the procedures.

To participate in this trial, patients need to have calcified lesions in their coronary arteries that require treatment. However, there are some important exclusions: for example, those who have had a heart attack in the past, certain heart surgeries, or specific health conditions may not be eligible. Participants will undergo various tests to assess their heart's microcirculation at different stages of the trial. Overall, this study aims to improve our understanding of how these treatments impact heart health, particularly in patients with calcified arteries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient diagnosed with stable coronary artery calcified lesion requiring Percutaneous coronary intervention
• Exclusion Criteria:
• • patients with a history of old myocardial infarction or history of coronary artery bypass grafting (CABG) or Percutaneous coronary intervention PCI
• • Patients with signs of chronic infection, prolong usage of corticosteroids or compromised immune system
• • patients had contraindication of adenosine triphosphate (ATP);
• • had a history of liver or renal function dysfunction
• • Patients with dementia
• • Patients being referred to CABG
• • unable to provide informed consent;
• • had pregnancy or life span \< 1 year.
• • Presence of sever structural valvular heart disease
• • Presence of significant left main disease
• • Unability to measure the index of microcirculatory resistance due to (death or retraction from the study ...etc)
• • Inability to perform successful PCI