Evaluation of COVID-19 Immune Barrier and Reinfection Risk

Launched by SUN YAT-SEN UNIVERSITY · Mar 15, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how well the immune system protects people from getting COVID-19 again after they've been vaccinated or infected with the Omicron variant. Researchers want to see how the levels of COVID-19 antibodies in the body change over time and how these antibodies can help protect against different variations of the virus. The study mainly involves healthcare workers at a hospital, who will be followed for 48 weeks to gather important information about their immune response.

To participate in the trial, you need to be a medical or administrative staff member at the Third Affiliated Hospital of Sun Yat-Sen University or someone who can commit to regular follow-ups. There are no age or gender restrictions, but you must be able to confirm if you've had COVID-19 before and remember when it happened. However, if you have serious respiratory diseases or other health conditions that could affect your immune system, you would not be eligible. Participants will regularly provide samples and information about their health, helping researchers understand how to strengthen immunity against COVID-19.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. No age limit, no gender limit;
• • 2. Medical staff, administrative and logistics staff who work in the Third Affiliated Hospital of Sun Yat-Sen University or other participants who can cooperate with the follow-up for 48 weeks;
• • 3. The participants need to be sure whether they have ever been infected with COVID-19, and need to be clearly remember the time when they first infected with COVID-19.
• Exclusion Criteria:
• • 1. Have the following serious respiratory diseases: such as asthma, bronchiectasis, chronic obstructive pulmonary disease, pulmonary interstitial disease, tuberculosis and other respiratory diseases that may interfere with symptom observation;
• • 2. Those with other serious diseases or disease history that affect immune function, including but not limited to uncontrolled and unresectable malignant tumors,hematological diseases, cachexia, active bleeding, severe malnutrition, mental diseases, autoimmune diseases, HIV, etc.
• • 3. Those who have long-term assignment plans and cannot return to the hospital regularly for follow-up.