Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project

Launched by UMC UTRECHT · Mar 7, 2023

Keywords

ClinConnect Summary

This study, called RED-LRGP (Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project), is a randomized trial testing whether a proactive, screen-like approach can find heart problems earlier than usual primary care. Participants undergo a structured early-diagnosis process that includes a questionnaire about symptoms, a focused physical exam, blood tests, an ECG, and an echocardiogram, and then researchers will compare it to usual care. The main goal is to see how often this approach detects coronary artery disease, atrial fibrillation, heart failure, or valvular heart disease within about one year.

Who can join: adults aged 50 to 80 who are part of the LRGP study and are willing to participate (with consent to share findings). People who already have coronary artery disease, atrial fibrillation, or heart failure, or who are having major cardiovascular surgery or revascularization within three months of enrolling, are not eligible. Up to about 1,476 people may take part at UMC Utrecht in the Netherlands. At this stage, the study is still enrolling by invitation, and results aren’t available yet, but participants can expect tests and follow-up for about a year to learn about detection rates, heart health, quality of life, risk factors, and costs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 50-80 years
• • Being a participant of LRGP
• • Having indicated in the LRGP informed consent to be interested in participating in further research.
• Exclusion Criteria:
• • Diagnosed with coronary artery disease and atrial fibrillation and heart failure.
• • Undergoing major (cardiovascular) surgery, and/or revascularisation therapy and/or transplantation treatment within 3 months after enrolment.
• • Not willing to give written informed consent for RED-LRGP.
• • Not allowing incidental findings to be reported to him/herself or their own GP.