Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Launched by ADVENTHEALTH TRANSLATIONAL RESEARCH INSTITUTE · Mar 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how aerobic exercise can help improve muscle health in people who have survived colorectal cancer, which includes cancer of the colon or rectum. The researchers want to see if regular aerobic exercise—like walking, running, or cycling—has different effects on the body compared to just paying attention to exercise without actually doing it. By focusing on muscle and fat in the body, they hope to learn more about how exercise can support recovery for cancer survivors.

To be eligible for this trial, participants need to be at least 18 years old and have had stage I, II, or III colorectal cancer that was surgically removed. They should not be exercising heavily already (less than 150 minutes of exercise a week) and must be cleared by their doctor to participate. If you join, you can expect to engage in an exercise program while being monitored for your health. The trial is currently looking for volunteers, and it’s a great opportunity for those who want to contribute to important research on cancer recovery through physical activity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years
• • Histologically confirmed stage I, II, or III colon or rectal cancer
• • Completed surgical resection with curative intent
• • Completed other cancer-directed treatments
• • Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
• • No planned major surgery during the study period
• • Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
• • Ability to provide written informed consent
• • Provide written approval by a qualified healthcare professional
• • Willing to be randomized
• Exclusion Criteria:
• • Evidence of metastatic or recurrent colorectal cancer
• • Concurrently actively treated other (non-colorectal) cancer
• • Scheduled to receive other postoperative cancer-directed treatment(s)
• • Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
• • Currently participating in another study with competing outcomes
• • Contraindications to magnetic resonance imaging
• • Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
• • Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
• • Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol