Multiparametric Ultrasound Study in Diagnosing GvHD

Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Mar 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking into a new way to diagnose intestinal graft-versus-host disease (aGvHD) using a special type of ultrasound. GvHD can happen after a patient receives a stem cell transplant, and it can cause symptoms like diarrhea. The researchers want to see if this bedside ultrasound can help identify the condition more accurately and quickly, which could improve patient care.

To participate in the study, you need to be at least 18 years old and have received your first stem cell transplant within the last year. You should also have started experiencing diarrhea between the day of your transplant and 100 days afterward. If you join the trial, you will be asked to sign a consent form and undergo the ultrasound procedure as part of the evaluation. It's important to note that individuals with certain health issues, such as severe heart or breathing problems, or those who have had a previous stem cell transplant, are not eligible to participate. This trial is currently recruiting participants, so if you think you might qualify, you can discuss it with your healthcare team.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Submitted to first allogeneic stem cell transplant during the 12 months period of enrollment of the study;
• • Diarrhea onset between day 0 and day +100 from transplant;
• • Signed informed consent.
• Exclusion Criteria:
• • Previous allogeneic stem cell transplantation;
• • Patients refusing to sign informed consent for the study;
• • Patients affected by severe cardiomyopathy and respiratory distress/insufficiency;
• • Patients unable to fully understand and accept study protocol for various problems