LDL-c Level Variability and Trained Immunity

Launched by WUHAN UNION HOSPITAL, CHINA · Mar 17, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different ways of taking atorvastatin, a medication that helps lower cholesterol, might affect the body's immune response and overall cholesterol levels. Specifically, the researchers want to see the difference between taking atorvastatin continuously versus taking it intermittently and how these methods impact cholesterol variability, which has been linked to heart-related health issues like heart attacks and strokes.

To participate in this study, you need to be at least 18 years old and either a man or a postmenopausal woman with elevated cholesterol levels (higher than 3.4 mmol/L). You should also be willing to follow the study procedures and provide informed consent. However, if you have a history of heart problems, certain organ dysfunctions, or cannot tolerate statins, you may not be eligible. If you join the trial, you can expect to undergo regular assessments to monitor your cholesterol and immune responses throughout the study. Your involvement could contribute to valuable insights on how to better manage cholesterol and improve heart health for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Voluntarily participate, understand and sign an informed consent form;
• • 2. Age ≥ 18 years old, male or postmenopausal female (defined as amenorrhea over 2 years with relevant clinical characteristics, such as age over 55 years old or menopausal cardiovascular symptoms such as hot flashes, night sweats, palpitations, etc.). Women with hysterectomy and/or bilateral oophorectomy may also be considered for inclusion in the group;
• • 3. Commit to complying with research procedures and cooperate in the implementation of the entire process of research; 4、LDL-c\>3.4mmol/L
• Exclusion Criteria:
• • 1. Previous cardiovascular history;
• • 2. Statins should not be discontinued in high-risk groups for cardiovascular events;
• • 3. Any known organ dysfunction;
• • 4. Intolerance to statins;
• • 5. Pregnant women, lactating women, or women of childbearing age who do not use effective contraception;
• • 6. Participating in other clinical trials;
• • 7. Unable to follow the study procedure.