Vascular Complications in Children From T1D Diagnosis

Launched by UNIVERSITY OF BRITISH COLUMBIA · Mar 16, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how and when children diagnosed with type 1 diabetes (T1D) might develop heart and blood vessel problems. Researchers want to understand the early signs of vascular damage, which can happen over time with T1D. The study is currently looking for participants between the ages of 8 and 17 who have been diagnosed with T1D within the last 14 weeks. To be eligible, children must be able to undergo a non-invasive test that measures how stiff their arteries are and wear a device that monitors their blood pressure for 24 hours.

If your child participates, they will help researchers learn more about the connection between T1D and heart health in young people. It's important to note that certain children, such as those with other serious health conditions or who are taking specific medications, will not be able to join the study. This research could ultimately help improve the understanding and management of cardiovascular health in children with type 1 diabetes.

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Eligibility criteria

• • Inclusion Criteria
• • 1. Between the ages of 8-18 years
• • 2. Within 14 weeks of type 1 diabetes diagnosis
• • 3. Ability and willingness to undergo non-invasive arterial stiffness assessment for 1hr and willingness to wear the 24-h automated blood pressure monitoring (ABPM) device.
• • Exclusion Criteria
• Children will be ineligible to participate in the study if they meet any of the following:
• • 1. Other cardiometabolic or endocrine diseases diagnosis (type 2 diabetes; familial disorders of cholesterol metabolism; lupus)
• • 2. Other genetic syndromes (Down Syndrome; Prader-Willi)
• • 3. Eating disorder diagnosis
• • 4. Transgender children taking hormone blockers or exogenous sex steroids
• • 5. Currently treated with medications known to affect metabolism (e.g. glucocorticoids, antipsychotics).