The Role of Type H Vessel Formation in Induced Membrane of Patients With Critical Size Bone Defect

Launched by CHANG GUNG MEMORIAL HOSPITAL · Mar 30, 2023

Keywords

ClinConnect Summary

This clinical trial is looking into how a special type of blood vessel, called type H vessels, affects the healing process of bones in patients with significant bone injuries, specifically those with open fractures. The researchers want to find out if these type H vessels are important for healing and if they can be used as a marker to help doctors understand how well a patient's bone is healing. Participants in the study will be individuals aged 20 to 80 who have specific types of open fractures with certain sizes of bone defects.

To participate, individuals must agree to join the study and meet certain health criteria. In this trial, researchers will collect samples of the induced membrane, a tissue formed in the healing process, as well as blood samples to study the type H vessels and their related indicators. Participants can expect to be randomly assigned to either a group receiving the induced membrane treatment or a control group without it. This is a vital step in understanding how to improve bone healing in patients with significant fractures. The trial is not yet recruiting, but it aims to provide valuable insights into bone healing in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Accept the informed consent form
• • Age: 20 years to 80 years
• • Type II and III open fracture with 2-6.5 cm defect size
• Exclusion Criteria:
• • Not accept the informed consent form
• • Age smaller than 20 years and over 80 years
• • Quit during the trial
• • patients with Notifiable infectious diseases such as AIDS and hepatitis as well as cancer