Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy
Launched by MEDICAL UNIVERSITY OF SOFIA · Mar 29, 2023
Trial Information
Current as of July 02, 2025
Completed
Keywords
ClinConnect Summary
Systemic glucocorticoids are the mainstay of treatment for active moderate-to-severe Graves' orbitopathy. However, there are a number of different glucocorticoid regimens with different total dosage, schemes of administration and duration. The goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe Graves' orbitopathy. The main questions it aims to answer are:
1. Are the two glucocorticoid regimens similarly effective?
2. Do the two glucocorticoid regimens have similar safety profile? The patients...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Active moderate-to-severe Graves' orbitopathy
- • Without previous treatment with glucocorticoids or orbital radiotherapy
- • Euthyroid state
- Exclusion Criteria:
- • Uncontrolled hyper- or hypothyroidism
- • Previously treated Graves' orbitopathy
- • Mild or sight-threatening form of Graves' orbitopathy
- • Inactive moderate-to-severe Graves' orbitopathy
- • Contraindications for glucocorticoid treatment
About Medical University Of Sofia
The Medical University of Sofia is a prestigious academic institution dedicated to advancing healthcare through innovative research and clinical trials. Renowned for its commitment to excellence in medical education, the university fosters a collaborative environment that integrates scientific inquiry with practical application. As a clinical trial sponsor, the Medical University of Sofia prioritizes patient safety and ethical standards, while aiming to contribute valuable insights to the medical community. Through rigorous study design and multidisciplinary expertise, the university seeks to enhance treatment options and improve health outcomes across diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Sofia, , Bulgaria
Patients applied
Trial Officials
Mariya D Stoynova, PhD
Principal Investigator
Medical University of Sofia: Medicinski universitet-Sofia
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials