A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Launched by MAYO CLINIC · Mar 30, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Type 2 Myocardial Infarction (T2MI), which is a type of heart attack that occurs without significant blockage in the main arteries of the heart. The researchers want to understand if patients with T2MI are more likely to have a related issue known as coronary microvascular disease (CMD), which affects the tiny blood vessels in the heart. The study is not yet recruiting participants, but it aims to include adults aged 65 to 74 who can provide consent and have a structurally normal heart. Those who experience atypical chest pain and need testing for CMD may also be eligible to participate.

If you join the study, you can expect to undergo assessments that will help determine your heart's microcirculation function. Participants will be carefully selected based on specific criteria to ensure safety, such as having no serious heart disease or prior heart surgeries. It's important to note that individuals with certain conditions, like significant coronary artery disease or recent heart events, will not be able to participate. This research could provide valuable insights into heart health for those with T2MI and help improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability to give informed consent
• • Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)
• • For controls: atypical chest pain with indication for CMD testing
• • For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value \>99th centile+ evidence of symptoms or signs of myocardial ischemia)
• Exclusion Criteria:
• • Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)
• • Known to have angiographically significant CAD/pressure wire positive for epicardial CAD
• • Inability to receive heparin products
• • Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
• • Prior coronary artery bypass grafting
• • Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)
• • Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation