The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · Mar 20, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how exposure to ozone, a common air pollutant, can cause lung injury. Researchers want to understand how certain cells in the lungs, called macrophages, respond to this exposure. If you participate in the study, you will attend two sessions where you will breathe either filtered air or a small amount of ozone. These sessions will be at least two weeks apart. After each session, you'll be asked to cough up a small amount of mucus, known as sputum, which will be analyzed to see how your lungs reacted.

To be eligible for this study, you need to be vaccinated against COVID-19 and should not have any serious health conditions like heart or lung disease, recent COVID-19 symptoms, diabetes, or a history of smoking in the past five years. You also should not be pregnant or have certain other health issues that could interfere with the study. This trial is open to all genders and is currently looking for participants aged between 65 and 74. If you decide to join, you'll help researchers learn more about how air pollution affects our lungs, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Vaccinated against COVID-19
• Exclusion Criteria:
• • Cardiovascular disease
• • Respiratory disease
• • Recent (within 4 weeks) respiratory or COVID-19 symptoms
• • Diabetes
• • Pregnancy
• • HIV Infection
• • History of smoking within the past 5 years.
• • Orthopedic or rheumatologic conditions which would interfere with cycle use
• • Inability to produce a sputum plug at screening
• • Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.