Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · Mar 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how a technique called Transcranial Magnetic Stimulation (TMS) can affect the way our brain processes space during navigation tasks. The researchers want to see if TMS can change a specific brain signal that relates to how we understand our surroundings and make decisions based on rewards while navigating in virtual environments. Essentially, they are looking at whether stimulating certain areas of the brain can help improve our ability to navigate and make choices.

To participate in this trial, you need to be between 18 and 55 years old and in good physical and mental health. You also should not have a history of certain neurological disorders or conditions that could affect the brain, such as seizures or serious mental health issues. Participants will engage in virtual navigation tasks while receiving TMS treatment and will need to follow study procedures. Overall, this trial aims to better understand how brain stimulation might enhance our spatial navigation abilities.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Be between the ages of 18 and 55 years old.
• • 2. Not received substance abuse treatment within the previous 30 days.
• • 3. Be in stable mental and physical health.
• • 4. If female, test non-pregnant.
• • 5. No evidence of focal or diffuse brain lesion on MRI.
• • 6. Be willing to provide informed consent.
• • 7. Be able to comply with protocol requirements and likely to complete all study procedures.
• Exclusion Criteria:
• • 1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia).
• • 2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \> 15 minutes, implanted electronic device, metal in the head, or pregnancy).
• • 3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.
• • 4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.
• • 5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.
• • uninterruptable central nervous system medication.