A Cohort Study of Correlation Between Mast Cells and Prognosis in Patients With Acute Myocardial Infarction

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Apr 5, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the role of mast cells, which are a type of immune cell involved in inflammation, in patients who have experienced an acute myocardial infarction, commonly known as a heart attack. The goal is to understand how these mast cells might relate to the recovery and overall prognosis of patients with this condition. Researchers will analyze certain markers related to mast cells in patients who meet specific criteria for heart attacks and are receiving standard medical care.

To be eligible for this study, participants must be at least 18 years old and diagnosed with a specific type of heart attack called ST Segment Elevation Myocardial Infarction (STEMI). This diagnosis typically involves chest pain and certain changes observed on an electrocardiogram (ECG). Participants should also be willing to cooperate with the study requirements. However, those who are taking certain medications like glucocorticoids, have allergies, autoimmune diseases, or certain medical conditions like pregnancy, are not eligible. If you join, you can expect to provide information about your condition and may undergo various tests to help researchers learn more about the connection between mast cells and heart attack prognosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age above 18 years old, regardless of gender;
• • 2) Meet STEMI diagnostic criteria (diagnostic criteria: ischemic chest pain lasting ≥30min; ST segment elevation of more than two adjacent leads or new left bundle branch block in ECG; With or without elevated myocardial markers) and receiving standard care for STEMI.
• • 3) Agree to and cooperate with the study
• Exclusion Criteria:
• • 1) The patient is taking or planning to take long-term oral or intravenous glucocorticoids (inhaled and topical hormones are allowed);
• • 2) Allergic diseases, autoimmune diseases or malignant tumors.
• • 3) Patients with metal implants or claustrophobia are not allowed to undergo an MRI examination;
• • 4) Pregnancy or lactation