Metabolic Adaptations to Weight Loss With and Without Exercise

Launched by UNIVERSITY OF MICHIGAN · Mar 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how adding exercise to a weight loss program affects health, especially focusing on fat tissue in the abdomen. Researchers want to understand how the combination of losing weight through diet and exercising can improve conditions related to obesity, such as insulin resistance and metabolic diseases. Participants will either engage in a moderate-intensity exercise program or not exercise at all while they aim to lose 10% of their body weight. The study will involve metabolic tests at different stages to see how these two approaches work together.

To join the study, participants need to be between 18 and 40 years old, have a body mass index (BMI) between 30 and 40, and be stable in their weight for at least two months. They should not be regularly exercising and must meet certain health criteria. Each participant’s involvement will last about 10 to 13 months, which includes the weight loss phase and follow-up assessments. During the follow-up, participants will have the freedom to choose their own diet and exercise habits while still being monitored at specific intervals. This trial aims to uncover valuable insights that could help improve weight loss strategies and overall health.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • Age: 18-40
• • Body Mass Index: 30-40 kg/m2
• • Weight stable (±3kg for greater than or equal to about 2 months)
• • No regularly planned exercise/physical activity
• • Women must have regularly occurring menses and must be premenopausal
• • Exclusion criteria
• • EKG abnormalities
• • Evidence/history of cardiovascular disease, diabetes or other metabolic disease
• • Medications known to affect lipid or glucose metabolism
• • Pregnant or lactating
• • Tobacco or e-cigarette use
• • Prior experience of hypersensitivity to insulin, human albumin, and potassium chloride injection.
• • Allergies/hypersensitivity to local anesthetics of the amide type (e.g., lidocaine)
• • History of hyperkalemia or potential for developing hyperkalemia (including but not limited to taking drugs that may induce hyperkalemia such as cardiac glycosides or potassium sparing diuretics)
• • Anti-coagulant medication (e.g., Coumadin, Rivaroxaban) and Lidocaine allergy/sensitivity are exclusion criteria for the biopsy procedure.