Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord Stimulation

Launched by ARTUR BIKTIMIROV · Mar 29, 2023

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ClinConnect Summary

The purpose of this study is to evaluate the effectiveness of neuromodulation for relief of phantom limb pain (PLP) using peripheral nerve (PNS) and spinal cord stimulation (SCS) with implantable electrodes.

The study is conducted to collect information on the role of non-adaptive neuroplasticity and inhibitory descending antinociceptive influences, which determine the effect of peripheral nerve and spinal cord stimulation with implanted electrodes in patients with phantom limb pain as a result of amputation of the lower limb. Neuromodulation is a potential treatment option for chronic pai...

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Eligibility criteria

• Inclusion criteria for the study:
• • Patients with implanted neuromodulation devices.
• • Amputation of the lower limb.
• • Age ranges from 18 to 65 years old.
• • The duration from the moment of amputation is from 12 months.
• • The presence of persistent chronic pain syndrome is from 4 to 10 points according to the Visual Analogue Scale
• • Absence of pregnancy at the time of implantation, confirmed by a pregnancy test.
• Exclusion criteria:
• • The presence of severe somatic pathology that prevents surgical treatment and participation in the study.
• • The presence of mental illness (including history), severe depression, suicidal tendencies, history of suicide.
• • The presence of gross orthopedic deformity in the limb above the amputation level.
• • History of oncology.
• • History of epilepsy.
• • Complicated TBI or history of stroke.
• • The impossibility of conducting electrical stimulation due to another somatic pathology.
• • Purulent septic pathology.
• • Drug addiction (including history).
• • Congenital malformation of the lower limb.
• • Anomalies in the development of the CNS.
• • Any conditions that fall under the exclusion criteria according to the researchers.