Marfan Syndrome Moderate Exercise Trial II

Launched by BAYLOR COLLEGE OF MEDICINE · Mar 30, 2023

Keywords

ClinConnect Summary

The Marfan Syndrome Moderate Exercise Trial II is a clinical study looking at how moderate exercise can affect adolescents and young adults with Marfan syndrome, a condition that affects connective tissues in the body and can lead to serious heart issues. Most patients with Marfan syndrome are advised to avoid certain physical activities due to potential risks, but this trial aims to explore whether supervised moderate exercise can actually be beneficial and help improve strength, endurance, and overall well-being.

To participate in this study, candidates need to be between 10 and 25 years old and have a confirmed diagnosis of Marfan syndrome. However, individuals who have had certain surgeries or have specific health conditions that could interfere with the exercise program are not eligible. Participants will be involved in a structured exercise program and monitored closely to see how it impacts their health. This study is currently recruiting, and it represents an important step in understanding how safe and effective exercise can be for those with Marfan syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female patients diagnosed with Marfan syndrome (defined by Ghent criteria and either a pathogenic variant in FBN1 or ectopia lentis)
• • Age 10-25 years at enrollment
• Exclusion Criteria:
• • 1. History of aortic surgery
• • 2. History of spinal surgery with implanted materials that may negatively impact MRI safety or imaging quality.
• • 3. Diagnosis of major congenital heart disease (ASD, VSD, bicuspid aortic valve, and mitral valve prolapse will not qualify as exclusion criteria)
• • 4. Condition limiting the ability to perform moderate exercise.
• • 5. Major concurrent diagnosis that may confound the interpretation of the effect of the proposed intervention on the proposed outcome measures.
• • 6. Aortic dilation meeting threshold for prophylactic aortic surgical intervention (\>/= 4.5 cm in diameter)