Exercise and Coronary Microvascular Disease

Launched by COREAALST BV · Mar 30, 2023

Keywords

ClinConnect Summary

This clinical trial, called "Exercise and Coronary Microvascular Disease," is studying how a structured exercise program, combined with standard medical treatment, affects patients with coronary microvascular disease, a condition that can cause chest pain without blockages in the large arteries. The goal is to see if adding a cardiac rehabilitation program improves patients' overall well-being and quality of life. To participate, people need to have non-obstructive coronary artery disease, experience chest pain, and show signs of microvascular dysfunction.

Eligible participants will be randomly assigned to one of two groups: one will receive the usual medical treatment, while the other will get both the medical treatment and the exercise program, which includes 36 personalized training sessions. The study will include around 204 people and will take place at a single site in Belgium. Participants can expect to undergo some tests to assess their heart function at the beginning and after four months. It's important to note that individuals with certain heart conditions or those unable to exercise won't be eligible for this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Non obstructive CAD (diameter stenosis \<50% visual or FFR \> 0.80)
• • Angina at presentation
• • Evidence of microvascular dysfunction (IMR ≥ 25)
• Exclusion Criteria:
• • Inability to give consent
• • Acute coronary syndrome (ACS)
• • Severe valve disease
• • Permanent AF
• • History of coronary artery bypass grafting (CABG)
• • Cardiomyopathies
• • Intolerance to adenosine
• • Hemodynamic instability
• • Not able to exercise