Comparison of Prophylactic Photobiomodulation Protocols in Chemoinduced Oral Mucositis in Oncology Patients

Launched by FEDERAL UNIVERSITY OF RIO GRANDE DO SUL · Mar 30, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different types of light therapy can help prevent and treat painful mouth sores, known as oral mucositis, in children and teens undergoing certain chemotherapy treatments for cancer. The researchers will compare two methods of using low-power lasers—one applied inside the mouth (intraoral) and another outside the mouth (extraoral)—to see which is more effective in reducing pain and improving the quality of life for these patients.

To participate, children and adolescents aged 30 months to 17 years with a confirmed cancer diagnosis who are receiving specific chemotherapy treatments at a hospital are eligible. Participants will be divided into two groups and monitored closely for ten days or until their mouth sores heal. The trial aims to improve care for young cancer patients by finding the best approach to manage this common and distressing side effect of treatment. If you have any questions about the study or the therapies involved, the medical team will be available to provide information and support.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of malignant neoplasia (hematological or solid tumors);
• • Responsible and participants agree to the study participation after reading and signing the Informed Consent Form (ICF) and Informed Term of Consent (TALE) for participation in Clinical Research;
• • They performed the chemotherapy infusions hospitalized in the pediatric oncology department of the 3rd east of HCPA;
• • Received the following chemotherapy protocols: MTX-HD, combination chemotherapy of MTX-HD, doxorubicin and cyclophosphamide; and MTX-HD and cyclophosphamide.
• Exclusion Criteria:
• * Participants will be excluded who:
• • Patients over the age of 18 years
• • Patients who will undergo HSCT