Urinary Creatinine Excretion Time in the Neonatal Period

Launched by CENTRAL HOSPITAL, NANCY, FRANCE · Apr 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how newborns excrete a substance called creatinine in their urine, which helps us understand their kidney function. When babies are born, their kidneys are still developing, and it can be hard to tell how well they are working. The researchers want to find out when newborns start to effectively excrete creatinine, which could improve how we manage treatments for babies who might have kidney issues.

To participate in this study, babies must be full-term (born at 37 weeks or more), have had a healthy birth, and be of normal weight. Unfortunately, babies who have certain health problems or who need extra medical care during their first few days of life won’t be eligible. If a baby qualifies, parents can expect to provide a urine sample that will help researchers learn more about kidney function in newborns. This information could lead to better care for infants with kidney concerns in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All full-term newborns (37WA or more)
• • From a physiological and spontaneous pregnancy
• • Good neonatal adaptation (Apgar 7 at 5 minutes of life)
• • Eutrophic (weight \> 10th percentile and \< 90th percentile)
• Exclusion Criteria:
• • Newborns for whom no urine sample is interpretable
• • Those with a significant clinical-biological anomaly
• • Neonates with hemodynamic disorders such as low blood pressure (median \< gestational age) or hypovolemia (shock, signs of dehydration, need for volume expansion) during the first 3 days of life