Shuiniujiao Dihuang Decoction With Variation for the Treatment of Psoriasis

Launched by CHINESE UNIVERSITY OF HONG KONG · Apr 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a traditional Chinese medicine formula called "Shuiniujiao Dihuang Decoction with Variation" (SDD) to see if it can help treat psoriasis vulgaris, a common skin condition that causes red, scaly patches. Psoriasis affects about 2% to 3% of people and can greatly impact their quality of life. Many current treatments can be expensive and may have side effects, so researchers want to explore a potentially safer and more accessible option with SDD.

To participate in this study, individuals aged between 18 and 65 with mild to moderate psoriasis (as measured by a specific scoring system) can sign up. Participants will be randomly divided into two groups—one receiving the SDD treatment and the other receiving a placebo (a treatment that looks the same but has no active ingredients)—for 12 weeks. Before joining, potential participants will be screened to ensure they do not have certain other skin conditions, recent treatments, or health issues that could affect the study. This trial is not yet recruiting, but it aims to provide valuable insights into how SDD might help people with psoriasis.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Mild to moderate chronic plaque psoriasis (PASI score 3 to 12).
• • Willingness to give informed consent.
• Exclusion Criteria:
• • Pustular or generalized erythrodermic psoriasis.
• • Psoriatic arthritis with syndrome of spleen-kidney yang deficiency according to Chinese medicine theory.
• • Systemic therapy for psoriasis 6 months prior to baseline.
• • Use topical medications for psoriasis 14 days prior to baseline such as retinoids, corticosteroids, vitamin D analogues, tazarotene and tacrolimus.
• • Has taken any antibiotics, probiotics and prebiotics 30 days prior to baseline.
• • UV light therapy 30 days prior to baseline.
• • Clinically significant laboratory abnormality in blood, liver or renal functions (≥1.5 times the upper limit of reference range).
• • History of allergy to Chinese herbs.
• • Known pregnant or lactation, or have a plan to conceive in 6 months.
• • Known active gastric or duodenal ulcer, or severe arrhythmia.
• • Unwillingness to comply with study protocol.
• • Any other condition that in the opinion of the investigators could disadvantage the subject.