Deucravacitinib in PG

Launched by DARTMOUTH-HITCHCOCK MEDICAL CENTER · Apr 6, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new medication called Deucravacitinib to see if it is safe and effective for treating pyoderma gangrenosum (PG), a condition that causes painful skin ulcers. The study is looking for adult men and women aged 18 to 70 who have been diagnosed with PG and meet specific medical criteria. To participate, women must not be pregnant or planning to become pregnant during the study, and everyone must agree to use reliable birth control methods while taking the medication and for at least 30 days after their last dose.

Participants in the trial will need to stop using certain other treatments for their PG before starting the study, which may take some time depending on the medications they have been using. Throughout the trial, participants will be monitored closely for safety and effectiveness. This study is not yet recruiting, so interested individuals will need to wait for the recruitment process to begin. If you or someone you know has PG and fits the eligibility criteria, this could be an opportunity to contribute to research that may lead to new treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women between the ages of 18-70 years old
• • Diagnosed with pyoderma gangrenosum requiring one major and at least 4 minor criteria
• • Women must not be pregnant, lactating, or planning pregnancy during the study period
• • Women of child-bearing potential must be on birth control for the duration of the treatment period.
• * Subjects must agree to the use of at least one of the following contraception methods for the entire duration of the study until at least 30 days after taking their last dose of study drug:
• • Women: Hormonal contraception (oral, injections, patch, implant, or vaginal-ring); Spiral (with or without hormones); any sterilization methods; a partner who has had a vasectomy; or sexual abstinence.
• • Other acceptable methods of contraception are male or female condoms (with or without spermicide) or a cap, diaphragm, or sponge with spermicide.
• • Willing to discontinue topical and/or systemic therapies, with the exception of oral rescue therapy with steroids.
• • The wash period for systemic therapies will largely depend on the specific treatment but, in general, will be at least 6 months for biologics and 3 months for other immune- suppressants such as cyclosporine, mycophenolate mofetil, methotrexate, etc. No wash out period is required for topicals.
• • Capable and willing to sign Institutional Review Board/IEC-approved written informed consent form in accordance with regulatory and institutional guidelines before the performance of any protocol-related procedures.
• Exclusion Criteria:
• • Patient under 18 years of age.
• • Patients with a history of inflammatory bowel disease.
• • Patients on systemic immunosuppressive/immune modulating therapy including: oral steroids, cyclosporine, mycophenolate mofetil, methotrexate, Azathioprine or TNFα inhibitor at time of starting deucravacitinib.
• • Patients currently enrolled in another investigational study.
• • Patients with a history or evidence of active infection and/or febrile illness within 7 days; or serious infection requiring antibiotic treatment within 30 days
• • Hepatitis C virus (HCV): subjects known to be positive for anti-HCV antibody or for HCV RNA detectable by polymerase chain reaction (PCR)
• • Hepatitis B virus (HBV): subjects known to be positive for hepatitis B surface antigen or for HBV DNA detectable by PCR
• • Human Immunodeficiency Virus (HIV) infection: subjects known to be HIV positive
• • History of active or inadequately treated latent tuberculosis (TB)
• • Known or suspected systemic or skin autoimmune disorder other than pyoderma gangrenosum
• • Any unstable major illness or evidence of unstable condition of major organ systems including psychiatric
• • Cancer or history of lymphoproliferative disease within last 5 years; exception is cutaneous basal cell carcinoma or squamous cell carcinoma that has been treated.
• • Major surgery within the last 4 weeks
• • Live vaccines within the last 60 days
• • Leukopenia (absolute WBC count \< 3000/mm3); Lymphopenia (ALC \< 500/mm3); Neutropenia (ANC \< 1000/mm3)
• • Thrombocytopenia (platelet count \< 100,000/mm3; Anemia (hemoglobin \< 9.0g/dL)
• • ALT/AST \> 3 X ULN and/or Total, unconjugated, and/or conjugated bilirubin \> 2 X ULN within 28 days of dosing