Cognitive Decline Following Deep Brain Stimulation

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Apr 10, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to understand how deep brain stimulation (DBS) affects thinking and memory in people with Parkinson's Disease. Researchers want to find specific brain patterns, using MRI scans, that can help predict how well someone will respond to this treatment. The study will involve 55 participants with Parkinson's Disease who are planning to have DBS surgery, as well as some healthy individuals for comparison.

To participate, you should be at least 18 years old and scheduled for DBS surgery if you have Parkinson's. Some people won't qualify, such as those with certain mental health issues or medical conditions that prevent them from undergoing an MRI scan. Participants will attend four visits, including an initial screening, an MRI session, and a follow-up visit to assess cognitive changes after the DBS procedure. This study aims to improve our understanding of how DBS impacts cognitive function, which is important for providing better care for individuals with movement disorders.

Gender

ALL

Eligibility criteria

• • PD Participants
• Inclusion Criteria:
• • Subjects above 18 years of age
• • Subjects who will undergo DBS surgery as part of their clinical care for PD
• Exclusion Criteria:
• • Uncorrected visual or hearing impairments, as indicated by self-report
• • Individuals who are pregnant or expect to become pregnant during the course of the study
• • Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
• • COPD with oxygen dependence
• • Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
• • Non-PD Control Participants
• Inclusion Criteria:
• • Subjects above 18 years of age
• • Age matched to participants in PD group
• Exclusion Criteria:
• • Diagnosis of Parkinsons Disease or other movement disorder
• • Untreated neuropsychiatric disorders
• • Uncorrected visual or hearing impairments, as indicated by self-report
• • Individuals who are pregnant or expect to become pregnant during the course of the study
• • Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
• • COPD with oxygen dependence
• • Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)