Continuous vs. Intermittent Infusion Vancomycin

Launched by AARON COOK · Apr 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to give a medication called vancomycin, which is often used to treat infections in hospitalized patients. The researchers want to find out if giving vancomycin continuously (without breaks) is better or worse for kidney health compared to giving it intermittently (with breaks). The study is taking place at the University of Kentucky and is looking for adult patients aged 18 and older who are currently hospitalized and have been prescribed vancomycin.

To participate, individuals must be in good enough health to give consent and should not have certain kidney problems or other specific conditions. If eligible, participants will be randomly assigned to one of the two treatment groups and will have their kidney function closely monitored throughout the trial. This research is important because it could help doctors understand the best way to use vancomycin, potentially leading to better care for patients receiving this medication.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥ 18 years of age
• • Hospitalized at University of Kentucky on a medical service (internal medicine or medical intensive care)
• • Prescribed ≥ 2 doses of vancomycin per treating physician
• • Be able to provide written, informed consent, or have a legally authorized representative (LAR) responsible for their care able to provide written, informed consent.
• Exclusion Criteria:
• • Chronic kidney disease (documented or prior to admission estimated GFR (eGFR) \<60 ml/min/1.73m2 using non-race-based creatinine GFR equation)
• • End stage kidney disease
• • Stage 1 or higher AKI per Kidney Disease: Improving Global Outcomes (KDIGO) classification (serum creatinine increase ≥ 0.3 mg/dl or 1.5-1.9 times baseline; urine output \< 0.5 ml/kg/hr for 6-12 hours)
• • Greater than 2 doses of vancomycin within the last 72 hours
• • Allergy to iohexol
• • Uroepithelial tumors
• • Pregnancy
• • Prisoner