Pressure Opening With Electrical Impedance Tomography

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Apr 11, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way to measure lung function in patients with Acute Respiratory Distress Syndrome (ARDS) or Acute Lung Injury. The researchers want to see if using a tool called electrical impedance tomography (EIT) can help doctors better understand how air moves in different parts of the lungs. This information may improve how mechanical ventilation is set up for patients, potentially leading to better care.

To participate in the trial, patients must be at least 18 years old and have a specific level of oxygen in their blood. They must also be on a type of breathing support that controls either volume or pressure. Participants will be sedated and lying on their back during the study. It’s important to know that certain conditions, like severe lung disease or unstable blood pressure, may prevent someone from joining the trial. If eligible, participants can expect to undergo a procedure that involves low-flow air being given to their lungs while both the ventilator and EIT monitor are used to gather valuable information about their lung function.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (≥18 years old).
• • Patients with PaO2/FiO2 ratio \<300 mmHg.
• • Volume- or pressure-controlled ventilation.
• • Sedated, with or without infusion of neuromuscular blockage.
• • Patients in supine position
• Exclusion Criteria:
• • Pneumothorax and bronchopleural fistula.
• • Severe hemodynamic instability (\>30 % increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min).
• • PaO2/FiO2 ratio \< 80 mmHg.
• • Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \< 30 % predicted).
• • Known or highly suspected elevated intracranial pressure (\>18 mmHg).
• • Impossibility to correctly position the EIT belt (e.g., burns chest drainage, etc.).
• • Contraindications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions, etc.).
• • Clinical judgement of the attending physician.
• • Pregnant or breastfeeding woman
• • Patient under guardianship, curators or safeguard of justice