A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
Launched by BRISTOL-MYERS SQUIBB · Apr 11, 2023
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying two different treatments for patients with newly diagnosed multiple myeloma, a type of blood cancer. Specifically, it compares iberdomide maintenance therapy to lenalidomide maintenance therapy after patients have undergone a procedure called autologous stem cell transplant (ASCT). The goal is to see which treatment is more effective in keeping the cancer from coming back.
To participate in this study, patients need to have a confirmed diagnosis of multiple myeloma and should have received specific initial treatments that include certain medications before their stem cell transplant. They should also have had a positive response to treatment, meaning their cancer has improved. The trial is currently recruiting participants aged between 65 and 74, and both men and women can join. Those who qualify can expect regular check-ups and monitoring throughout the study to assess how well the treatments are working. This trial is important as it aims to find better ways to manage multiple myeloma after a stem cell transplant.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • Confirmed diagnosis of symptomatic multiple myeloma (MM).
- • Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2.
- • Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) \[eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)\] with or without a CD38 monoclonal antibody, daratumumab + bortezomib/thalidomide/dexamethasone \[D-VTd\] and daratumumab + bortezomib/ lenalidomide/dexamethasone \[D-VRd\]), or VCd / daratumumab + bortezomib/cyclophosphamide/dexamethasone \[D-VCd\], and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted.
- • Participants within 12 months (single transplant) or 15 months (tandem transplant) from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria.
- • Exclusion Criteria
- • Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy.
- • Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma.
- • Known central nervous system/meningeal involvement of MM.
- • Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years.
- • Other protocol-defined Inclusion/Exclusion criteria apply.
About Bristol Myers Squibb
Bristol-Myers Squibb (BMS) is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With a robust portfolio of products across multiple therapeutic areas, including oncology, immunology, cardiovascular, and fibrotic diseases, BMS emphasizes cutting-edge research and a commitment to advancing medical science through clinical trials. The company is driven by a mission to provide transformative therapies, leveraging collaboration and scientific expertise to address unmet medical needs and improve patient outcomes worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Adelaide, South Australia, Australia
Edmonton, Alberta, Canada
Philadelphia, Pennsylvania, United States
Madison, Wisconsin, United States
Badalona, , Spain
Box Hill, Victoria, Australia
Jerusalem, , Israel
Philadelphia, Pennsylvania, United States
Seoul, , Korea, Republic Of
Cleveland, Ohio, United States
Morristown, New Jersey, United States
Houston, Texas, United States
Tampa, Florida, United States
Singapore, , Singapore
Hadera, , Israel
Worcester, Massachusetts, United States
Ottawa, Ontario, Canada
Montreal, Quebec, Canada
Odense, , Denmark
Jacksonville, Florida, United States
Houston, Texas, United States
Barcelona, , Spain
Paris, , France
Taipei, , Taiwan
Waratah, New South Wales, Australia
Tübingen, , Germany
Tainan, , Taiwan
Beijing, , China
Taoyuan, , Taiwan
Chongqing, Chongqing, China
Seoul, , Korea, Republic Of
Kuopio, , Finland
Freiburg, , Germany
Paris, , France
Jinan, Shandong, China
Nanjing, , China
Pavia, , Italy
Limoges, , France
Changchun, Jilin, China
Dallas, Texas, United States
Jena, , Germany
Rome, , Italy
Westbury, New York, United States
Pamplona, , Spain
Jinan, , China
Kortrijk, , Belgium
Hamburg, , Germany
Ramat Gan, , Israel
Goyang Si, , Korea, Republic Of
Tianjin, Tianjin, China
New Taipei City, , Taiwan
Fuzhou, , China
Medellin, , Colombia
Haifa, , Israel
Changsha, Hunan, China
Changsha, Hunan, China
Busan, , Korea, Republic Of
Kumamoto Shi, Kumamoto, Japan
Milano, Mi, Italy
Linz, , Austria
Guangzhou, Guangdong, China
Brno, , Czechia
Oviedo, Asturias, Spain
Chiba Shi, , Japan
Osakasayama Shi, , Japan
Weston, Florida, United States
Tübingen, Baden Württemberg, Germany
Eugene, Oregon, United States
Lille, , France
New York, New York, United States
New Brunswick, New Jersey, United States
Qingdao, , China
Wuhan, , China
Roma, , Italy
Floridablanca, , Colombia
Seoul, , Korea, Republic Of
Katowice, , Poland
Orange, California, United States
Milano, Mi, Italy
Palma De Mallorca, , Spain
Ulsan, , Korea, Republic Of
Kayseri, , Turkey
Petah Tikva, , Israel
Shanghai, , China
Porto, , Portugal
Singapore, , Singapore
Toledo, Ohio, United States
Sunto Gun, , Japan
Edirne, , Turkey
Edinburgh, , United Kingdom
Vienna, , Austria
Minato Ku, , Japan
Toulouse, , France
Isehara Shi, , Japan
Nagasaki Shi, , Japan
Xuzhou, Jiangsu, China
Houston, Texas, United States
St. Pölten, , Austria
Olomouc, , Czechia
Rochester, Minnesota, United States
Nantes, , France
Shenyang, Liaoning, China
Genova, Ge, Italy
Borås, , Sweden
Worcester, Massachusetts, United States
Seongnam Si, Gyeonggi Do, , Korea, Republic Of
Augusta, Georgia, United States
Kaohsiung, , Taiwan
Athens, , Greece
Pittsburgh, Pennsylvania, United States
Chattanooga, Tennessee, United States
Beijing, , China
Edinburgh, , United Kingdom
Prague, , Czechia
Weston, Florida, United States
Changsha, Hunan, China
Kagoshima Shi, , Japan
Córdoba, , Argentina
Gifu Shi, , Japan
Tampa, Florida, United States
Warsaw, , Poland
Hangzhou, Zhejiang, China
Shibuya Ku, , Japan
New York, New York, United States
Clayton, Victoria, Australia
Kumamoto Shi, , Japan
Jerusalem, , Israel
Winston Salem, North Carolina, United States
Craiova, Dolj, Romania
Nagoya Shi, , Japan
Beijing, Beijing, China
Ann Arbor, Michigan, United States
Kanazawa Shi, , Japan
Nashville, Tennessee, United States
New York, New York, United States
Aurora, Colorado, United States
Fort Collins, Colorado, United States
Pensacola, Florida, United States
Atlanta, Georgia, United States
Chicago, Illinois, United States
Westwood, Kansas, United States
Clinton, Maryland, United States
Ann Arbor, Michigan, United States
Detroit, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Rochester, Minnesota, United States
Hattiesburg, Mississippi, United States
Kansas City, Missouri, United States
Lebanon, New Hampshire, United States
New York, New York, United States
Charlotte, North Carolina, United States
Cincinnati, Ohio, United States
York, Pennsylvania, United States
Dallas, Texas, United States
Milwaukee, Wisconsin, United States
Buenos Aires, B, Argentina
Mar Del Plata, B, Argentina
Pilar, B, Argentina
Ciudad Autonoma Buenos Aires, Caba, Argentina
Ciudad Autonoma Buenos Aires, Caba, Argentina
Córdoba, , Argentina
Waratah, New South Wales, Australia
Adelaide, South Australia, Australia
Box Hill, Victoria, Australia
Heidelberg, Victoria, Australia
Clayton, , Australia
Nedlands, , Australia
Randwick, , Australia
Linz, , Austria
St. Pölten, , Austria
Vienna, , Austria
Kortrijk, Vwv, Belgium
Gilly, , Belgium
Curitiba, Pr, Brazil
Niterói, Rj, Brazil
São Paulo, Sp, Brazil
Barretos, , Brazil
Porto Alegre, , Brazil
Ribeirao Preto, , Brazil
Rio De Janeiro, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
Sao Paulo, , Brazil
Ottawa, Ontario, Canada
Edmonton, , Canada
Quebec, , Canada
Vancouver, , Canada
Los ángeles, Bi, Chile
Providencia, Rm, Chile
Santiago, , Chile
Temuco, , Chile
Vitacura, , Chile
Hefei, Ah, China
Beijing Shi, Beijing, China
Beijing, Beijing, China
Guangzhou Shi, Guangdong, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Zhengzhou, Hainan, China
Wuhan, Hb, China
Changsha, Hunan, China
Nanjing, Jiangsu, China
Xuzhou, Jiangsu, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Xi'an City, Shaanxi, China
Jinan, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Tianjin, Tianjin, China
Tianjin, Tianjin, China
Tianjin, Tianjin, China
Hangzhou, Zhejiang, China
Beijing, , China
Binzhou, , China
Changsha, , China
Chongqing, , China
Hangzhou Shi, , China
Nanchang Shi, , China
Nanjing, , China
Nanning Shi, , China
Qingdao, , China
Wenzhou Shi, , China
Wuhan Shi, , China
Bogota, , Colombia
Bogota, , Colombia
Floridablanca, , Colombia
Medellin, , Colombia
Valledupar, , Colombia
Brno, , Czechia
Hradec Kralove, , Czechia
Olomouc, , Czechia
Ostrava, , Czechia
Prague, , Czechia
Praha, , Czechia
Odense, , Denmark
Kuopio, , Finland
Amiens, , France
Bayonne, , France
Caen, , France
Creteil, , France
La Roche Sur Yon Cedex 9, , France
Lille, , France
Limoges, , France
Lyon, , France
Nantes, , France
Nice, , France
Paris, , France
Paris, , France
Paris, , France
Pierre Benite, , France
Toulouse, , France
Villejuif, , France
Ulm, Bw, Germany
Dusseldorf, Northwest, Germany
Hamm, Northwest, Germany
Berlin, , Germany
Freiburg, , Germany
Jena, , Germany
Tübingen, , Germany
Thessaloniki, B, Greece
Rio, G, Greece
Athina, I, Greece
Athens, , Greece
Thessaloniki, , Greece
Hong Kong, Hk, Hong Kong
Debrecen, Hb, Hungary
Haifa, , Iceland
Chandigarh, Ch, India
Cochin, Kl, India
Kolhapur, Mh, India
Nagpur, Mh, India
Pune, Mh, India
Pune, Mh, India
Bhubaneswar, Odisha, India
Kolkata, Wb, India
Bangalore, , India
Navi Mumbai, , India
Beer Ya'aqov, , Israel
Hadera, , Israel
Jerusalem, , Israel
Jerusalem, , Israel
Petah Tikva, , Israel
Ramat Gan, , Israel
Tel Aviv Yafo, , Israel
Tel Aviv Yafo, , Israel
Catania, Ct, Italy
Catanzaro, Cz, Italy
Genova, Ge, Italy
Milano, Mi, Italy
Milano, Mi, Italy
Pisa, Pi, Italy
Roma, Rm, Italy
Torino, To, Italy
Bergamo, , Italy
Catanzaro, , Italy
Naples, , Italy
Rome, , Italy
Chiba Shi, , Japan
Gifu Shi, , Japan
Higashiibaraki Gun, , Japan
Hiroshima Shi, , Japan
Isehara Shi, , Japan
Kagoshima Shi, , Japan
Kamakura Shi, , Japan
Kanazawa Shi, , Japan
Kobe Shi, , Japan
Koto Ku, , Japan
Kumamoto Shi, , Japan
Maebashi Shi, , Japan
Minato Ku, , Japan
Nagasaki Shi, , Japan
Nagoya Shi, , Japan
Osakasayama Shi, , Japan
Saitama Shi, , Japan
Sapporo Shi, , Japan
Sendai Shi, , Japan
Shibukawa Shi, , Japan
Shibuya Ku, , Japan
Shizuoka Shi, , Japan
Dong Gu, Ulsan, Korea, Republic Of
Busan, , Korea, Republic Of
Goyang Si, , Korea, Republic Of
Seoul, , Korea, Republic Of
Mexico, Cmx, Mexico
Guanajuato, Gto, Mexico
Toluca De Lerdo, Mex, Mexico
Hermosillo, Son, Mexico
Mexico City, , Mexico
Amsterdam, Nh, Netherlands
Dordrecht, , Netherlands
Bydgoszcz, Kp, Poland
Lodz, Ld, Poland
Gdansk, Pomorskie, Poland
Gliwice, , Poland
Katowice, , Poland
Lodz, , Poland
Lublin, , Poland
Warsaw, , Poland
Wroclaw, , Poland
Almada, Lisboa, Portugal
Braga, , Portugal
Coimbra, , Portugal
Porto, , Portugal
Bucureşti, B, Romania
Craiova, Dolj, Romania
Iasi, Is, Romania
Cluj Napoca, , Romania
Cluj Napoca, , Romania
Singapore, , Singapore
Singapore, , Singapore
Oviedo, Asturias, Spain
Barcelona, B, Spain
Cáceres, Cc, Spain
Las Palmas De Gran Canaria, Las Palmas, Spain
Murcia, Mu, Spain
Valencia, Vc, Spain
Badalona, , Spain
Palma De Mallorca, , Spain
Pamplona, , Spain
Aarau 1, , Swaziland
Stockholm, Ab, Sweden
Luleå, Bd, Sweden
Goeteborg, , Sweden
Helsingborg, , Sweden
Linkoping, , Sweden
Kao Hsiung, , Taiwan
Kaohsiung, , Taiwan
New Taipei City, , Taiwan
Tainan, , Taiwan
Ankara, , Turkey
Bornova, , Turkey
Edirne, , Turkey
Istanbul, , Turkey
Izmir, , Turkey
Kayseri, , Turkey
Yenimahalle, , Turkey
Aberdeen, Abd, United Kingdom
Derby, Dby, United Kingdom
Bournemouth, Dor, United Kingdom
Stafford, Sts, United Kingdom
London, , United Kingdom
Oxford, , United Kingdom
Windsor, , United Kingdom
Athens, Georgia, United States
Sao Paulo, Sp, Brazil
Helsinki, , Finland
Cluj Napoca, Jud. Cluj, Romania
Aarau, , Switzerland
Surrey, British Columbia, Canada
Pavia, , Italy
Borås, , Sweden
Durham, North Carolina, United States
Vancouver, British Columbia, Canada
Kortrijk, , Belgium
Changsha, Hunan, China
Kamakura Shi, Kanagawa, Japan
Monterrey, Nl, Mexico
Athens, Georgia, United States
Philadelphia, Pennsylvania, United States
Ashdod, , Israel
Haifa, , Israel
Hiroshima City, , Japan
Ibaraki, , Japan
Portsmouth, Ham, United Kingdom
Wuhan, , China
Dong Gu, , Korea, Republic Of
Rotterdam, Zh, Netherlands
Izmir, , Turkey
Madison, Wisconsin, United States
Vienna, , Austria
Charleroi, Wht, Belgium
Chongqing, Chongqing, China
Tianjin, Tianjin, China
Changsha, , China
Fuzhou, , China
Amiens Cedex 1, , France
La Roche Sur Yon, , France
Hamm, , Germany
Haifa, , Israel
Gdansk, Pm, Poland
Aarau 1, , Switzerland
Mineola, New York, United States
Clayton, Victoria, Australia
Edmonton, Alberta, Canada
Monterrey, , Mexico
çankaya, , Turkey
Xi'an City, , China
Lodz, Ld, Poland
Grand Rapids, Michigan, United States
Germantown, Tennessee, United States
Wenzhou Shi, , China
Hamburg, , Germany
Larisa, , Greece
Seongnam Si, Gyeonggi Do, , Korea, Republic Of
Seoul, , Korea, Republic Of
Bucureşti, B, Romania
Uddevalla, , Sweden
Taipei, , Taiwan
Taoyuan, , Taiwan
Lebanon, New Hampshire, United States
Philadelphia, Pennsylvania, United States
Randwick, New South Wales, Australia
Nedlands, Western Australia, Australia
Temuco, , Chile
Beijing, Beijing, China
Guangzhou Shi, Guangdong, China
Shanghai, , China
Thessaloniki, B, Greece
Thessaloniki, , Greece
Beer Ya'aqov, , Israel
Kamakura Shi, Kanagawa, Japan
Koto Ku, , Japan
Katowice, , Poland
Cluj Napoca, Jud. Cluj, Romania
Cáceres, Cc, Spain
Las Palmas De Gran Canaria, Las Palmas, Spain
Murcia, Mu, Spain
Ankara, , Turkey
Helsinki, , Finland
Erlangen, By, Germany
Iasi, Is, Romania
Cleveland, Ohio, United States
Wooster, Ohio, United States
Temuco, , Chile
Maebashi Shi, , Japan
Worcester, Massachusetts, United States
Mayfield Heights, Ohio, United States
Quebec, , Canada
Hefei, Ah, China
Zhengzhou City, Henan, China
Nanchang, Jiangxi, China
Amiens Cedex 1, , France
Pisa, Pi, Italy
Sendai Shi, , Japan
Valencia, Vc, Spain
Oxford, , United Kingdom
Stoke On Trent, , United Kingdom
Windsor, , United Kingdom
Vienna, , Austria
Vitacura, , Chile
Praha, , Czechia
Ulm, Bw, Germany
Hamm, , Germany
Torino, To, Italy
Naples, , Italy
Saitama Shi, , Japan
Cankaya, , Turkey
Aberdeen, Abd, United Kingdom
Derby, Dby, United Kingdom
Stoke On Trent, Staffordshire, United Kingdom
Fort Collins, Colorado, United States
Rochester, Minnesota, United States
Guangzhou, Guangdong, China
Monteria, Cordoba, Colombia
Caen, , France
Bangalore, Karnataka, India
Kolhapur, Mh, India
Stoke On Trent, Staffordshire, United Kingdom
Hiroshima Shi, , Japan
Montreal, Quebec, Canada
Santiago, , Chile
Suzhou Shi, , China
Firenze, Fl, Italy
Windsor, Berkshire, United Kingdom
Tampa, Florida, United States
Tampa, Florida, United States
Cleveland, Ohio, United States
Mayfield Heights, Ohio, United States
Wooster, Ohio, United States
Rio De Janeiro, Rj, Brazil
Ribeirão Preto, Sp, Brazil
São Paulo, Sp, Brazil
Berlin, Be, Germany
Bhubaneswar, Odisha, India
Catania, Ct, Italy
Braga, , Portugal
London, , United Kingdom
Mayfield Heights, Ohio, United States
Berlin, Be, Germany
Kolhapur, Mh, India
Nagpur, Mh, India
Ashdod, , Israel
Firenze, Fi, Italy
Cankaya, , Turkey
Xi'an City, Shaanxi, China
Guangzhou, , China
Monteria, , Colombia
La Roche Sur Yon, , France
Hong Kong, Hk, Hong Kong
Debrecen, Hb, Hungary
Pune, Mh, India
Gliwice, , Poland
Lublin, , Poland
Yenimahalle, , Turkey
Charleroi, Wht, Belgium
Suzhou Shi, , China
Monteria, Cor, Colombia
Medellin, , Colombia
Amsterdam, Nh, Netherlands
Dordrecht, , Netherlands
Ciudad Autonoma Buenos Aires, Caba, Argentina
Ciudad Autonoma Buenos Aires, Caba, Argentina
Valledupar, , Colombia
Creteil, , France
Erlangen, By, Germany
Firenze, Fi, Italy
Bydgoszcz, Kp, Poland
Uddevalla, , Sweden
Istanbul, , Turkey
Bournemouth, Dor, United Kingdom
Portsmouth, Ham, United Kingdom
Gdansk, Pm, Poland
Nanjing, Jiangsu, China
Bogota, , Colombia
Bangalore, Karnataka, India
Pune, Mh, India
Izmir, , Turkey
Kansas, Ohio, United States
Cottbus, Bb, Germany
Bayreuth, By, Germany
Munchen, By, Germany
Hamburg, Hh, Germany
Hildesheim, Ni, Germany
Gottingen, , Germany
Cochin, Kl, India
Chemnitz, Sn, Germany
Lodz, Ld, Poland
Prague 2, , Czechia
Kolkata, Wb, India
Charleroi, Wht, Belgium
Shenzhen, Guangdong, China
Madrid, , Spain
Pilar, B, Argentina
Athina, I, Greece
Winston Salem, North Carolina, United States
Chongqing, Cq, China
Xi'an, Shaanxi, China
Shanghai, Shanghai, China
Ningbo, Zhejiang, China
Changsha, , China
Wuhan Shi, , China
Muenchen, By, Germany
Rio, G, Greece
Chandigarh, Ch, India
Shibukawa Shi, Gunma, Japan
Sapporo Shi, , Japan
Coimbra, , Portugal
Bogota, , Colombia
Augsburg, By, Germany
Marburg, , Germany
Istanbul, , Turkey
Almere, , Netherlands
Beijing, Beijing, China
Larisa, , Greece
Isehara Shi, , Japan
Kao Hsiung, , Taiwan
Ankara, , Turkey
Brooklyn, New York, United States
Bydgoszcz, , Poland
Charlotte, North Carolina, United States
Toledo, Ohio, United States
Itabashi Ku, , Japan
Nerima Ku, , Japan
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported