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Search / Trial NCT05827016

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

Launched by BRISTOL-MYERS SQUIBB · Apr 11, 2023

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

Multiple Myeloma Iberdomide Cc 220 Lenalidomide Mm Ndmm Maintenance Autologous Stem Cell Transplant Asct Cel Mo D Cereblon Modulators

ClinConnect Summary

This clinical trial is studying two different treatments for patients with newly diagnosed multiple myeloma, a type of blood cancer. Specifically, it compares iberdomide maintenance therapy to lenalidomide maintenance therapy after patients have undergone a procedure called autologous stem cell transplant (ASCT). The goal is to see which treatment is more effective in keeping the cancer from coming back.

To participate in this study, patients need to have a confirmed diagnosis of multiple myeloma and should have received specific initial treatments that include certain medications before their stem cell transplant. They should also have had a positive response to treatment, meaning their cancer has improved. The trial is currently recruiting participants aged between 65 and 74, and both men and women can join. Those who qualify can expect regular check-ups and monitoring throughout the study to assess how well the treatments are working. This trial is important as it aims to find better ways to manage multiple myeloma after a stem cell transplant.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria
  • Confirmed diagnosis of symptomatic multiple myeloma (MM).
  • Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2.
  • Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) \[eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)\] with or without a CD38 monoclonal antibody, daratumumab + bortezomib/thalidomide/dexamethasone \[D-VTd\] and daratumumab + bortezomib/ lenalidomide/dexamethasone \[D-VRd\]), or VCd / daratumumab + bortezomib/cyclophosphamide/dexamethasone \[D-VCd\], and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted.
  • Participants within 12 months (single transplant) or 15 months (tandem transplant) from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria.
  • Exclusion Criteria
  • Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy.
  • Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma.
  • Known central nervous system/meningeal involvement of MM.
  • Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

About Bristol Myers Squibb

Bristol-Myers Squibb (BMS) is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With a robust portfolio of products across multiple therapeutic areas, including oncology, immunology, cardiovascular, and fibrotic diseases, BMS emphasizes cutting-edge research and a commitment to advancing medical science through clinical trials. The company is driven by a mission to provide transformative therapies, leveraging collaboration and scientific expertise to address unmet medical needs and improve patient outcomes worldwide.

Locations

Adelaide, South Australia, Australia

Edmonton, Alberta, Canada

Philadelphia, Pennsylvania, United States

Madison, Wisconsin, United States

Badalona, , Spain

Box Hill, Victoria, Australia

Jerusalem, , Israel

Philadelphia, Pennsylvania, United States

Seoul, , Korea, Republic Of

Cleveland, Ohio, United States

Morristown, New Jersey, United States

Houston, Texas, United States

Tampa, Florida, United States

Singapore, , Singapore

Hadera, , Israel

Worcester, Massachusetts, United States

Ottawa, Ontario, Canada

Montreal, Quebec, Canada

Odense, , Denmark

Jacksonville, Florida, United States

Houston, Texas, United States

Barcelona, , Spain

Paris, , France

Taipei, , Taiwan

Waratah, New South Wales, Australia

Tübingen, , Germany

Tainan, , Taiwan

Beijing, , China

Taoyuan, , Taiwan

Chongqing, Chongqing, China

Seoul, , Korea, Republic Of

Kuopio, , Finland

Freiburg, , Germany

Paris, , France

Jinan, Shandong, China

Nanjing, , China

Pavia, , Italy

Limoges, , France

Changchun, Jilin, China

Dallas, Texas, United States

Jena, , Germany

Rome, , Italy

Westbury, New York, United States

Pamplona, , Spain

Jinan, , China

Kortrijk, , Belgium

Hamburg, , Germany

Ramat Gan, , Israel

Goyang Si, , Korea, Republic Of

Tianjin, Tianjin, China

New Taipei City, , Taiwan

Fuzhou, , China

Medellin, , Colombia

Haifa, , Israel

Changsha, Hunan, China

Changsha, Hunan, China

Busan, , Korea, Republic Of

Kumamoto Shi, Kumamoto, Japan

Milano, Mi, Italy

Linz, , Austria

Guangzhou, Guangdong, China

Brno, , Czechia

Oviedo, Asturias, Spain

Chiba Shi, , Japan

Osakasayama Shi, , Japan

Weston, Florida, United States

Tübingen, Baden Württemberg, Germany

Eugene, Oregon, United States

Lille, , France

New York, New York, United States

New Brunswick, New Jersey, United States

Qingdao, , China

Wuhan, , China

Roma, , Italy

Floridablanca, , Colombia

Seoul, , Korea, Republic Of

Katowice, , Poland

Orange, California, United States

Milano, Mi, Italy

Palma De Mallorca, , Spain

Ulsan, , Korea, Republic Of

Kayseri, , Turkey

Petah Tikva, , Israel

Shanghai, , China

Porto, , Portugal

Singapore, , Singapore

Toledo, Ohio, United States

Sunto Gun, , Japan

Edirne, , Turkey

Edinburgh, , United Kingdom

Vienna, , Austria

Minato Ku, , Japan

Toulouse, , France

Isehara Shi, , Japan

Nagasaki Shi, , Japan

Xuzhou, Jiangsu, China

Houston, Texas, United States

St. Pölten, , Austria

Olomouc, , Czechia

Rochester, Minnesota, United States

Nantes, , France

Shenyang, Liaoning, China

Genova, Ge, Italy

Borås, , Sweden

Worcester, Massachusetts, United States

Seongnam Si, Gyeonggi Do, , Korea, Republic Of

Augusta, Georgia, United States

Kaohsiung, , Taiwan

Athens, , Greece

Pittsburgh, Pennsylvania, United States

Chattanooga, Tennessee, United States

Beijing, , China

Edinburgh, , United Kingdom

Prague, , Czechia

Weston, Florida, United States

Changsha, Hunan, China

Kagoshima Shi, , Japan

Córdoba, , Argentina

Gifu Shi, , Japan

Tampa, Florida, United States

Warsaw, , Poland

Hangzhou, Zhejiang, China

Shibuya Ku, , Japan

New York, New York, United States

Clayton, Victoria, Australia

Kumamoto Shi, , Japan

Jerusalem, , Israel

Winston Salem, North Carolina, United States

Craiova, Dolj, Romania

Nagoya Shi, , Japan

Beijing, Beijing, China

Ann Arbor, Michigan, United States

Kanazawa Shi, , Japan

Nashville, Tennessee, United States

New York, New York, United States

Aurora, Colorado, United States

Fort Collins, Colorado, United States

Pensacola, Florida, United States

Atlanta, Georgia, United States

Chicago, Illinois, United States

Westwood, Kansas, United States

Clinton, Maryland, United States

Ann Arbor, Michigan, United States

Detroit, Michigan, United States

Grosse Pointe Woods, Michigan, United States

Rochester, Minnesota, United States

Hattiesburg, Mississippi, United States

Kansas City, Missouri, United States

Lebanon, New Hampshire, United States

New York, New York, United States

Charlotte, North Carolina, United States

Cincinnati, Ohio, United States

York, Pennsylvania, United States

Dallas, Texas, United States

Milwaukee, Wisconsin, United States

Buenos Aires, B, Argentina

Mar Del Plata, B, Argentina

Pilar, B, Argentina

Ciudad Autonoma Buenos Aires, Caba, Argentina

Ciudad Autonoma Buenos Aires, Caba, Argentina

Córdoba, , Argentina

Waratah, New South Wales, Australia

Adelaide, South Australia, Australia

Box Hill, Victoria, Australia

Heidelberg, Victoria, Australia

Clayton, , Australia

Nedlands, , Australia

Randwick, , Australia

Linz, , Austria

St. Pölten, , Austria

Vienna, , Austria

Kortrijk, Vwv, Belgium

Gilly, , Belgium

Curitiba, Pr, Brazil

Niterói, Rj, Brazil

São Paulo, Sp, Brazil

Barretos, , Brazil

Porto Alegre, , Brazil

Ribeirao Preto, , Brazil

Rio De Janeiro, , Brazil

Rio De Janeiro, , Brazil

Salvador, , Brazil

Sao Paulo, , Brazil

Ottawa, Ontario, Canada

Edmonton, , Canada

Quebec, , Canada

Vancouver, , Canada

Los ángeles, Bi, Chile

Providencia, Rm, Chile

Santiago, , Chile

Temuco, , Chile

Vitacura, , Chile

Hefei, Ah, China

Beijing Shi, Beijing, China

Beijing, Beijing, China

Guangzhou Shi, Guangdong, China

Guangzhou, Guangdong, China

Shenzhen, Guangdong, China

Zhengzhou, Hainan, China

Wuhan, Hb, China

Changsha, Hunan, China

Nanjing, Jiangsu, China

Xuzhou, Jiangsu, China

Nanchang, Jiangxi, China

Changchun, Jilin, China

Shenyang, Liaoning, China

Xi'an City, Shaanxi, China

Jinan, Shandong, China

Shanghai, Shanghai, China

Shanghai, Shanghai, China

Tianjin, Tianjin, China

Tianjin, Tianjin, China

Tianjin, Tianjin, China

Hangzhou, Zhejiang, China

Beijing, , China

Binzhou, , China

Changsha, , China

Chongqing, , China

Hangzhou Shi, , China

Nanchang Shi, , China

Nanjing, , China

Nanning Shi, , China

Qingdao, , China

Wenzhou Shi, , China

Wuhan Shi, , China

Bogota, , Colombia

Bogota, , Colombia

Floridablanca, , Colombia

Medellin, , Colombia

Valledupar, , Colombia

Brno, , Czechia

Hradec Kralove, , Czechia

Olomouc, , Czechia

Ostrava, , Czechia

Prague, , Czechia

Praha, , Czechia

Odense, , Denmark

Kuopio, , Finland

Amiens, , France

Bayonne, , France

Caen, , France

Creteil, , France

La Roche Sur Yon Cedex 9, , France

Lille, , France

Limoges, , France

Lyon, , France

Nantes, , France

Nice, , France

Paris, , France

Paris, , France

Paris, , France

Pierre Benite, , France

Toulouse, , France

Villejuif, , France

Ulm, Bw, Germany

Dusseldorf, Northwest, Germany

Hamm, Northwest, Germany

Berlin, , Germany

Freiburg, , Germany

Jena, , Germany

Tübingen, , Germany

Thessaloniki, B, Greece

Rio, G, Greece

Athina, I, Greece

Athens, , Greece

Thessaloniki, , Greece

Hong Kong, Hk, Hong Kong

Debrecen, Hb, Hungary

Haifa, , Iceland

Chandigarh, Ch, India

Cochin, Kl, India

Kolhapur, Mh, India

Nagpur, Mh, India

Pune, Mh, India

Pune, Mh, India

Bhubaneswar, Odisha, India

Kolkata, Wb, India

Bangalore, , India

Navi Mumbai, , India

Beer Ya'aqov, , Israel

Hadera, , Israel

Jerusalem, , Israel

Jerusalem, , Israel

Petah Tikva, , Israel

Ramat Gan, , Israel

Tel Aviv Yafo, , Israel

Tel Aviv Yafo, , Israel

Catania, Ct, Italy

Catanzaro, Cz, Italy

Genova, Ge, Italy

Milano, Mi, Italy

Milano, Mi, Italy

Pisa, Pi, Italy

Roma, Rm, Italy

Torino, To, Italy

Bergamo, , Italy

Catanzaro, , Italy

Naples, , Italy

Rome, , Italy

Chiba Shi, , Japan

Gifu Shi, , Japan

Higashiibaraki Gun, , Japan

Hiroshima Shi, , Japan

Isehara Shi, , Japan

Kagoshima Shi, , Japan

Kamakura Shi, , Japan

Kanazawa Shi, , Japan

Kobe Shi, , Japan

Koto Ku, , Japan

Kumamoto Shi, , Japan

Maebashi Shi, , Japan

Minato Ku, , Japan

Nagasaki Shi, , Japan

Nagoya Shi, , Japan

Osakasayama Shi, , Japan

Saitama Shi, , Japan

Sapporo Shi, , Japan

Sendai Shi, , Japan

Shibukawa Shi, , Japan

Shibuya Ku, , Japan

Shizuoka Shi, , Japan

Dong Gu, Ulsan, Korea, Republic Of

Busan, , Korea, Republic Of

Goyang Si, , Korea, Republic Of

Seoul, , Korea, Republic Of

Mexico, Cmx, Mexico

Guanajuato, Gto, Mexico

Toluca De Lerdo, Mex, Mexico

Hermosillo, Son, Mexico

Mexico City, , Mexico

Amsterdam, Nh, Netherlands

Dordrecht, , Netherlands

Bydgoszcz, Kp, Poland

Lodz, Ld, Poland

Gdansk, Pomorskie, Poland

Gliwice, , Poland

Katowice, , Poland

Lodz, , Poland

Lublin, , Poland

Warsaw, , Poland

Wroclaw, , Poland

Almada, Lisboa, Portugal

Braga, , Portugal

Coimbra, , Portugal

Porto, , Portugal

Bucureşti, B, Romania

Craiova, Dolj, Romania

Iasi, Is, Romania

Cluj Napoca, , Romania

Cluj Napoca, , Romania

Singapore, , Singapore

Singapore, , Singapore

Oviedo, Asturias, Spain

Barcelona, B, Spain

Cáceres, Cc, Spain

Las Palmas De Gran Canaria, Las Palmas, Spain

Murcia, Mu, Spain

Valencia, Vc, Spain

Badalona, , Spain

Palma De Mallorca, , Spain

Pamplona, , Spain

Aarau 1, , Swaziland

Stockholm, Ab, Sweden

Luleå, Bd, Sweden

Goeteborg, , Sweden

Helsingborg, , Sweden

Linkoping, , Sweden

Kao Hsiung, , Taiwan

Kaohsiung, , Taiwan

New Taipei City, , Taiwan

Tainan, , Taiwan

Ankara, , Turkey

Bornova, , Turkey

Edirne, , Turkey

Istanbul, , Turkey

Izmir, , Turkey

Kayseri, , Turkey

Yenimahalle, , Turkey

Aberdeen, Abd, United Kingdom

Derby, Dby, United Kingdom

Bournemouth, Dor, United Kingdom

Stafford, Sts, United Kingdom

London, , United Kingdom

Oxford, , United Kingdom

Windsor, , United Kingdom

Athens, Georgia, United States

Sao Paulo, Sp, Brazil

Helsinki, , Finland

Cluj Napoca, Jud. Cluj, Romania

Aarau, , Switzerland

Surrey, British Columbia, Canada

Pavia, , Italy

Borås, , Sweden

Durham, North Carolina, United States

Vancouver, British Columbia, Canada

Kortrijk, , Belgium

Changsha, Hunan, China

Kamakura Shi, Kanagawa, Japan

Monterrey, Nl, Mexico

Athens, Georgia, United States

Philadelphia, Pennsylvania, United States

Ashdod, , Israel

Haifa, , Israel

Hiroshima City, , Japan

Ibaraki, , Japan

Portsmouth, Ham, United Kingdom

Wuhan, , China

Dong Gu, , Korea, Republic Of

Rotterdam, Zh, Netherlands

Izmir, , Turkey

Madison, Wisconsin, United States

Vienna, , Austria

Charleroi, Wht, Belgium

Chongqing, Chongqing, China

Tianjin, Tianjin, China

Changsha, , China

Fuzhou, , China

Amiens Cedex 1, , France

La Roche Sur Yon, , France

Hamm, , Germany

Haifa, , Israel

Gdansk, Pm, Poland

Aarau 1, , Switzerland

Mineola, New York, United States

Clayton, Victoria, Australia

Edmonton, Alberta, Canada

Monterrey, , Mexico

çankaya, , Turkey

Xi'an City, , China

Lodz, Ld, Poland

Grand Rapids, Michigan, United States

Germantown, Tennessee, United States

Wenzhou Shi, , China

Hamburg, , Germany

Larisa, , Greece

Seongnam Si, Gyeonggi Do, , Korea, Republic Of

Seoul, , Korea, Republic Of

Bucureşti, B, Romania

Uddevalla, , Sweden

Taipei, , Taiwan

Taoyuan, , Taiwan

Lebanon, New Hampshire, United States

Philadelphia, Pennsylvania, United States

Randwick, New South Wales, Australia

Nedlands, Western Australia, Australia

Temuco, , Chile

Beijing, Beijing, China

Guangzhou Shi, Guangdong, China

Shanghai, , China

Thessaloniki, B, Greece

Thessaloniki, , Greece

Beer Ya'aqov, , Israel

Kamakura Shi, Kanagawa, Japan

Koto Ku, , Japan

Katowice, , Poland

Cluj Napoca, Jud. Cluj, Romania

Cáceres, Cc, Spain

Las Palmas De Gran Canaria, Las Palmas, Spain

Murcia, Mu, Spain

Ankara, , Turkey

Helsinki, , Finland

Erlangen, By, Germany

Iasi, Is, Romania

Cleveland, Ohio, United States

Wooster, Ohio, United States

Temuco, , Chile

Maebashi Shi, , Japan

Worcester, Massachusetts, United States

Mayfield Heights, Ohio, United States

Quebec, , Canada

Hefei, Ah, China

Zhengzhou City, Henan, China

Nanchang, Jiangxi, China

Amiens Cedex 1, , France

Pisa, Pi, Italy

Sendai Shi, , Japan

Valencia, Vc, Spain

Oxford, , United Kingdom

Stoke On Trent, , United Kingdom

Windsor, , United Kingdom

Vienna, , Austria

Vitacura, , Chile

Praha, , Czechia

Ulm, Bw, Germany

Hamm, , Germany

Torino, To, Italy

Naples, , Italy

Saitama Shi, , Japan

Cankaya, , Turkey

Aberdeen, Abd, United Kingdom

Derby, Dby, United Kingdom

Stoke On Trent, Staffordshire, United Kingdom

Fort Collins, Colorado, United States

Rochester, Minnesota, United States

Guangzhou, Guangdong, China

Monteria, Cordoba, Colombia

Caen, , France

Bangalore, Karnataka, India

Kolhapur, Mh, India

Stoke On Trent, Staffordshire, United Kingdom

Hiroshima Shi, , Japan

Montreal, Quebec, Canada

Santiago, , Chile

Suzhou Shi, , China

Firenze, Fl, Italy

Windsor, Berkshire, United Kingdom

Tampa, Florida, United States

Tampa, Florida, United States

Cleveland, Ohio, United States

Mayfield Heights, Ohio, United States

Wooster, Ohio, United States

Rio De Janeiro, Rj, Brazil

Ribeirão Preto, Sp, Brazil

São Paulo, Sp, Brazil

Berlin, Be, Germany

Bhubaneswar, Odisha, India

Catania, Ct, Italy

Braga, , Portugal

London, , United Kingdom

Mayfield Heights, Ohio, United States

Berlin, Be, Germany

Kolhapur, Mh, India

Nagpur, Mh, India

Ashdod, , Israel

Firenze, Fi, Italy

Cankaya, , Turkey

Xi'an City, Shaanxi, China

Guangzhou, , China

Monteria, , Colombia

La Roche Sur Yon, , France

Hong Kong, Hk, Hong Kong

Debrecen, Hb, Hungary

Pune, Mh, India

Gliwice, , Poland

Lublin, , Poland

Yenimahalle, , Turkey

Charleroi, Wht, Belgium

Suzhou Shi, , China

Monteria, Cor, Colombia

Medellin, , Colombia

Amsterdam, Nh, Netherlands

Dordrecht, , Netherlands

Ciudad Autonoma Buenos Aires, Caba, Argentina

Ciudad Autonoma Buenos Aires, Caba, Argentina

Valledupar, , Colombia

Creteil, , France

Erlangen, By, Germany

Firenze, Fi, Italy

Bydgoszcz, Kp, Poland

Uddevalla, , Sweden

Istanbul, , Turkey

Bournemouth, Dor, United Kingdom

Portsmouth, Ham, United Kingdom

Gdansk, Pm, Poland

Nanjing, Jiangsu, China

Bogota, , Colombia

Bangalore, Karnataka, India

Pune, Mh, India

Izmir, , Turkey

Kansas, Ohio, United States

Cottbus, Bb, Germany

Bayreuth, By, Germany

Munchen, By, Germany

Hamburg, Hh, Germany

Hildesheim, Ni, Germany

Gottingen, , Germany

Cochin, Kl, India

Chemnitz, Sn, Germany

Lodz, Ld, Poland

Prague 2, , Czechia

Kolkata, Wb, India

Charleroi, Wht, Belgium

Shenzhen, Guangdong, China

Madrid, , Spain

Pilar, B, Argentina

Athina, I, Greece

Winston Salem, North Carolina, United States

Chongqing, Cq, China

Xi'an, Shaanxi, China

Shanghai, Shanghai, China

Ningbo, Zhejiang, China

Changsha, , China

Wuhan Shi, , China

Muenchen, By, Germany

Rio, G, Greece

Chandigarh, Ch, India

Shibukawa Shi, Gunma, Japan

Sapporo Shi, , Japan

Coimbra, , Portugal

Bogota, , Colombia

Augsburg, By, Germany

Marburg, , Germany

Istanbul, , Turkey

Almere, , Netherlands

Beijing, Beijing, China

Larisa, , Greece

Isehara Shi, , Japan

Kao Hsiung, , Taiwan

Ankara, , Turkey

Brooklyn, New York, United States

Bydgoszcz, , Poland

Patients applied

0 patients applied

Trial Officials

Bristol-Myers Squibb

Study Director

Bristol-Myers Squibb

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported