Incidence, Impact and Mechanisms of Perioperative Right VEntricular Dysfunction (IMPRoVE)

Launched by NHS NATIONAL WAITING TIMES CENTRE BOARD · Apr 11, 2023

Keywords

ClinConnect Summary

The IMPRoVE study is looking into how common right heart failure, known as right ventricular dysfunction, is after major surgeries, and whether this condition can lead to poorer recovery for patients. The research aims to help us understand the impact this heart issue has on patients undergoing specific types of surgeries, such as hip or knee replacements and major colorectal or vascular operations.

To be part of this study, participants need to be over 18 years old and scheduled for one of the surgeries mentioned. They should also be able to give their consent and understand English well enough to follow instructions during the study. However, people who are pregnant, have had major surgery recently, or have certain heart conditions may not be eligible. If you join the study, you will undergo tests, including heart imaging, to help doctors learn more about how right ventricular dysfunction affects patients after surgery. This research is important as it could improve care and outcomes for future patients.

Gender

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Eligibility criteria

• • Main echocardiography study
• Inclusion Criteria:
• • 1. Provision of informed consent
• • 2. Age \>18 years
• • 3. Planned elective primary hip or knee joint replacement under spinal anaesthesia, major colorectal, major vascular surgery or surgery requiring one lung ventilation with or without lung resection
• Exclusion Criteria:
• • 1. Pregnancy
• • 2. On-going participation in any investigational research which could undermine the scientific basis of the study
• • 3. Previous major surgery within three months prior to recruitment
• • 4. Previous participation in the IMPRoVE study at any time
• • 5. Inadequate comprehension of English resulting in inability to comply with instructions while undergoing investigations required for main study and sub-studies.
• Additional exclusion criteria applicable to the T1 CMR sub-study includes:
• • 1. Atrial fibrillation at baseline
• • 2. Contraindication to cardiac magnetic resonance imaging (metal work in body etc)
• • 3. Contraindication to IV Gadolinium: acute or chronic renal failure, allergy to contrast