Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
Launched by MASSACHUSETTS GENERAL HOSPITAL · Apr 12, 2023
Trial Information
Current as of July 23, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring how our eyes respond to different types of light and how this affects our sleep and daily rhythms, particularly looking at how these responses might differ based on a person's age and sex. Researchers want to understand if the way our pupils react to light is connected to when we sleep, our body's internal clock, and how hormones react to light.
To participate, individuals must be between 18 and 85 years old, typically go to sleep between 10 PM and 1 AM, and wake up between 5:30 AM and 8:30 AM. Participants will first undergo a special eye exam and fill out some questionnaires. If eligible, they will wear a watch for a week to track their activity and light exposure, followed by a 3-day stay in a research room at Mass General Hospital. During this stay, their pupil responses to light and other factors will be tested. It's important to note that certain medical conditions and medications could make someone ineligible for this study.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • (i) 18-85 years old.
- • (ii) Habitual sleep onset 10 pm- 1 am (healthy controls only);
- • (iii) Habitual wake onset 5:30 am- 8:30 am (healthy controls only);
- • (iv) vision correctable to 20/30;
- • (v) stable medically.
- • (vi) ability to speak, understand, and read English at a high school level
- Exclusion Criteria:
- • (i) Color blind by Ishihara Color Blindness Test;
- • (ii) any history of eye trauma, surgery or abnormality (e.g., retinopathy, glaucoma, cataracts, amblyopia, macular degeneration, congenital color vision deficiencies, or any type of blindness) besides correctable vision abnormalities (e.g., with glasses); any abnormalities on clinical eye exam (e.g., neuritis, Neuromyelitis optica, treated or untreated glaucoma) such that the ophthalmologist recommends the participant not be studied; Limited cataracts (e.g., Lens Opacities Classification (LOCS) III grade \<2) will be allowed and documented during the eye exam. Eye drops that affect pupil size or contractility (e.g. mydriatics, miotics); drops to treat glaucoma (e.g., pilocarpine, brimonidine, other drops like artificial tear drops, or anti-inflammatory drops would not be exclusionary)
- • (iii) current or history of neurologic or psychiatric disease including autonomic function disorder or migraines; psychiatric disorder requiring medications in a first degree relative (healthy controls only); limited-duration counseling without prescription medications will not be exclusionary; (iv) current or history of circadian rhythm sleep-wake disorder (healthy controls only);
- • (v) prescription or non-prescription drugs affecting the pupil (e.g., affecting autonomic function), sleep, melatonin (e.g., lithium, alpha- and beta-adrenergic antagonists), and/or circadian rhythms (e.g., beta blockers, non-steroidal anti-inflammatory drugs, tricyclics);
- • (vi) Other disorders that can affect or may be affected by intrinsically photosensitive Retinal Ganglion Cell (ipRGC) function, including diabetes mellitus, multiple sclerosis, Parkinson's disease, seasonal affective disorder;
- • (vii) shift- or night-work in past three months; history of night work in preceding 3 year period
- • (viii) crossing more than 2 time zones in past three months;
- • (ix) presence of depression as assessed by a Beck Depression Inventory (BDI) score \>14.
- • (x) pregnant or less than 6 weeks post-partum or breast-feeding
About Massachusetts General Hospital
Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Boston, Massachusetts, United States
Patients applied
Trial Officials
Elizabeth B Klerman, MD PhD
Principal Investigator
Massachusetts General Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported