A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer

Launched by SHANGHAI YUNYING MEDICAL TECHNOLOGY · Apr 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for patients with relapsed or hard-to-treat head and neck cancers using a special virus called R130. The goal is to see if this virus can help shrink tumors and improve the safety and effectiveness of treatment. The trial is open to adults aged 18 to 75 who have been diagnosed with head and neck cancer and have not responded to standard treatments. Participants should have one or more measurable tumors that can be targeted with the treatment and must not have severe health issues affecting their heart, liver, or other major organs.

If you or someone you know qualifies and decides to participate, you will receive the R130 virus injection, and the medical team will closely monitor your health throughout the study. It’s important to understand that this trial is in the early stages, which means researchers are still learning about the best ways to use this treatment. Participants will need to commit to follow-up visits and meet certain health criteria to ensure their safety during the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with head and neck cancer clearly diagnosed by histology and/or cytology, without systematic metastasis, and failure of standard treatment.
• • 2. Age 18 to 75 years.
• • 3. No absolute or relative centasis contraindiction，have at least one measurable lesion (according to RECIST 1.1 criteria) that is amenable to intratumoral drug delivery.
• • 4. No severe functinonal falure of heart, brain, liver, kidney and lung.
• • 5. Subjects with ECOG score of 0-2, and expected survival of 3 months or more.
• • 6. No evidence of clinically significant immunosuppression.
• 7. Patients must have the following hematologic parameters, Coagulation functions and hepatic and renal function during the screening period:
• • White Blood Cell (WBC)≥3.0×10\^9/L；
• • Absolute Lymphocyte Count (ANC)≥1.5×10\^9/L;
• • Platelet≥100×10\^9/L；
• • Prothrombin time (PT) or activated Partial Thromboplastin Time（APTT）≤1.5×ULN;
• • Serum Creatinine (Scr)≤1.5×ULN
• • Alanine aminotransferase(AST/ALT) ≤3×ULN;
• • Total Bilirubin(TBIL)≤1.5×ULN.
• • 8. Be able to understand and sign the informed consent document;
• • 9. Be able to stick to follow-up visit plan and other requirements in the agreement.
• • Exclusion Criteria.
• • 1. With a history of allergy to similar drugs.
• • 2. With hematological diseases, malignant tumors of the central nervous system, or combined with other malignant tumors.
• • 3. pregnancy, breast feeding.
• • 4. Current active hepatitis B, active hepatitis C, immunodeficiency virus or other active infection of clinical significance.
• • 5. Impaired function of important organs or a history of organ transplantation.
• • 6. Receiving antiherpes simplex virus therapy such as acyclovir, ganciclovir, vancomycin, and acepromazine within 4 weeks.
• • 7. Have had antitumor therapy, including endocrine, chemotherapy, radiotherapy, targeted therapy, immunotherapy and antitumor herbal therapy,4 weeks prior to the first dose.
• • 8. Have had any serious adverse reactions associated with immunotherapy and have not recovered to CTCAE 5.0 grade rating 0 or 1 level of toxicity after previous antineoplastic therapy.
• • 9. Subjects with any severe and/or uncontrolled disease, including: a) poorly controlled hypertension (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 100 mmHg); b) suffering from class I or higher myocardial ischemia or myocardial infarction, arrhythmia (QTc ≥ 470 ms and ≥ grade 2 congestive heart failure (New York Heart Association (NYHA) classification); c) active or uncontrolled severe infection (≥ CTCAE grade 2 infection); d) Patients with previous organ transplantation, bone marrow transplantation (hematopoietic stem cell transplantation) and severe immune deficiency; e) Urine routine suggesting urine protein ≥++ and confirmed 24-hour urine protein quantification \> 1.0 g.
• • 10. Patients with past history of type I diabetes mellitus.
• • 11. Severe abnormalities in thyroid and cortisol testing; active, known or suspected autoimmune disease requiring systemic therapy.
• • 12. Patients with active bleeding or severe coagulation dysfunction.
• • 13. Researchers considering the test subject as having a history of other severe systemic diseases, or other reasons inappropriate for the clinical study.