Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes

Launched by CHUNGNAM NATIONAL UNIVERSITY HOSPITAL · Apr 24, 2023

Keywords

ClinConnect Summary

1. For study subjects who survived after out-of-hospital cardiac arrest, prognosis was evaluated using Cerebral Performance Category (CPC) scores on days 10-14 after return of spontaneous circulation (ROSC). A CPC score of 1-2 indicates a good neurological prognosis, while a score of 3-5 indicates a poor neurological prognosis. Only subjects with CPC scores of 1-2 were included in this study.
2. Blood samples were collected through venous puncture at days 10-14, 3 months, and 6 months after ROSC, and the obtained blood was drawn into an serum separating tube (SST) bottle without anticoagula...

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Eligibility criteria

• Inclusion Criteria:
• • Patients who visited the hospital emergency room due to cardiac arrest within 60 months after Institutional Review Board (IRB) approval
• • Patients with Glasgow Coma Scale (GCS) less than 8 points after spontaneous circulation recovery
• • Patients who are 18 years old or older
• • Patients who underwent targeted temperature management (TTM)
• • Patients who showed good neurological outcomes with CPC 1-2 points after evaluating the prognosis on days 10-14 after ROSC
• Exclusion Criteria:
• • Under 18 years of age
• • cardiac arrest cause is trauma
• • Patients who have not undergone targeted temperature management
• • Patients treated with extracorporeal membrane oxygenation (ECMO)
• • Patients who were not able to undergo SNSB testing
• • Patients who could not be followed up until 6 months after ROSC