Gut-oral Axis Microbiome in Autism Spectrum Disorders

Launched by IRCCS BURLO GAROFOLO · Apr 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between gut and oral bacteria and Autism Spectrum Disorder (ASD). Researchers believe that the bacteria in our gut and mouth can affect not only our digestive health but also our brain and behavior. By comparing the gut and oral bacteria of children with ASD to those without the disorder, the study aims to understand how these bacteria might contribute to the symptoms of ASD and related gastrointestinal issues.

To participate, children aged 1 to 17 who are Caucasian and either have a diagnosis of ASD or are healthy without any neurological disorders can apply. However, those who have taken antibiotics or probiotics in the month before the study, or have other neurological or chronic inflammatory diseases, will not be eligible. Participants will provide samples of their gut and oral bacteria, which will help researchers learn more about how these microorganisms interact with health and behavior. This study is currently recruiting, and the findings could lead to new insights into managing ASD symptoms.

Gender

ALL

Eligibility criteria

• • INCLUSION CRITERIA
• • Case group
• • 1. Caucasian
• • 2. Diagnosed with ASD or with a newly formulated diagnosis of ASD
• • 3. Aged between 1 and 17 years
• • Control group
• • 1. Caucasian
• • 2. Healthy at the time of sampling
• • 3. No ASD or other neurological disorders
• • 4. Aged between 1 and 17 years
• • EXCLUSION CRITERIA
• • 1. Antibiotic use in the month before sample collection
• • 2. Probiotic use in the month before sample collection
• • 3. Other neurological diseases
• • 4. Chronic inflammatory diseases
• • 5. The use of constipation drugs during the three days before sample collection