ONLOOP Trial: Evaluating a New Surveillance and Support System for Survivors of Childhood Cancer in Ontario

Launched by THE HOSPITAL FOR SICK CHILDREN · Apr 14, 2023

Keywords

ClinConnect Summary

The ONLOOP Trial is a study designed to help adult survivors of childhood cancer in Ontario, Canada, stay on top of important health screenings. Many childhood cancer treatments can lead to long-term health issues, like heart disease and new cancers, but many survivors don’t get the regular check-ups they need. The ONLOOP program aims to remind these survivors to complete tests such as echocardiograms for heart health, mammograms and breast MRIs for breast cancer, and colonoscopies for colorectal cancer. By participating in this trial, survivors will either receive helpful reminders and personalized health information about their specific risks and needed screenings or continue with their usual care for about 13 months.

To be eligible for the trial, participants must be at least 18 years old, have been diagnosed with cancer before age 18, and have completed treatment at one of Ontario's specialized childhood cancer programs. They should also have missed their recommended screenings by at least six months. If you or a loved one fits this description, you could play a valuable role in helping to improve health outcomes for childhood cancer survivors. Participants can expect to receive supportive materials and have the option to involve their family doctor in their care, ensuring everyone is informed about their health needs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Survivors of childhood cancer who are currently aged 18 and older
• • Diagnosed with cancer before age 18 between 1986-2017
• • At least 5 years from most recent childhood cancer event (latest of primary diagnosis, relapse, or second cancer before age 18)
• • Treated at one of Ontario's five specialized childhood cancer programs
• • Received radiation and/or anthracycline treatment that increased the survivor's risk of cardiomyopathy, breast cancer, and/or colorectal cancer
• • Overdue for guideline-recommended surveillance by ≥6 months (mammogram and breast MRI, colonoscopy, and/or echocardiogram)
• Exclusion Criteria:
• • Was not diagnosed or was not fully treated at one of Ontario's five pediatric cancer centres
• • Developed a second cancer or relapse of their primary cancer after age 18
• • Not currently living in Ontario or address deemed ineligible by Ontario Health
• • Opted out of a similar Ontario Health program (eg, the Ontario Breast Screening Program)
• • Previously opted out of receiving invitations for Ontario Health research studies or similar communications