Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery

Launched by UNIVERSITÄT MÜNSTER · Apr 25, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how certain hormones in the body, part of a system called the RAAS-axis, behave in patients undergoing heart surgery. Specifically, it compares patients who have surgery using a heart-lung machine (on-pump surgery) with those who have surgery without it (off-pump surgery). The goal is to see if there are any differences in the levels of these hormones that could affect recovery, especially for those experiencing low blood pressure after surgery, known as vasoplegia or vasoplegic shock.

To participate in this study, you need to be an adult who is scheduled for coronary artery bypass graft surgery, either on-pump or off-pump. You will need to give your written consent to join. However, if you are having emergency surgery, taking certain heart medications that weren’t paused, or have specific health conditions like severe kidney or lung disease, you may not be eligible. If you choose to participate, you can expect to contribute to important research that could improve treatment and outcomes for future heart surgery patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery
• • 2. written informed consent
• Exclusion Criteria:
• • 1. emergency surgery in the context of acute coronary syndrome
• • 2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
• • 3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m²
• • 4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
• • 5. Chronic pulmonary hypertension
• • 6. Pregnancy or breastfeeding
• • 7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
• • 8. Persons held in an institution by legal or official order