NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Apr 18, 2023

Keywords

ClinConnect Summary

The NeoTAILOR clinical trial is exploring a new way to personalize treatment for women with stage II or III ER-positive, HER2-negative breast cancer. This study aims to identify which patients truly need chemotherapy before surgery and to improve treatment outcomes, especially for Black patients. By using specific biomarkers (which are biological indicators) to guide the choice of neoadjuvant therapy (treatment given before surgery), the researchers hope to enhance the chances of a positive response to treatment.

To participate in this trial, women must be postmenopausal and diagnosed with a certain type of breast cancer that meets specific criteria, such as having a tumor that is at least 2 cm in size. Eligible participants will undergo a series of tests and may receive hormone therapy or standard chemotherapy before their surgery. The trial is currently recruiting participants, and those interested will be fully informed about the study and must agree to follow all the necessary procedures. This trial is a great opportunity for eligible patients to receive potentially more effective treatment tailored to their needs.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Histologically or cytologically confirmed newly diagnosed clinical stage II or III (by AJCC 8th edition - at least T2, any N, M0 or if N1+ then any T) ER-positive (ER \> 10%), any PR, and HER2-negative breast cancer with complete surgical excision of the breast cancer after neoadjuvant therapy as the treatment goal.
• • HER2 negative must be assessed by FISH or IHC staining 0 or 1+ according to ASCO/CAP guidelines.
• * A palpable mass is not required; however, tumor size must be either:
• • ≥2 cm in one dimension by clinical or radiographic examination (WHO criteria), if clinically axillary lymph node negative OR
• • Measureable (≥10 mm) by modified RECIST v1.1 for breast MRI (see Section 9.0), if histologically confirmed resectable locoregional nodal involvement.
• • ECOG performance status 0 or 1.
• • Eligible to receive neoadjuvant aromatase inhibitor, as per treating physician.
• • Eligible to receive neoadjuvant standard of care anthracycline- and/or taxane-based chemotherapy regimen, as per treating physician.
• • Able to tolerate breast MRI with intravenous contrast administration. Must be able to complete the applicable MRI screening evaluation form.
• • Adequate bone marrow and organ function, as determined by the treating physician.
• • Known history of hepatitis C virus (HCV) infection is permissible provided the patient has been treated and cured.
• • At least 18 years of age.
• * Postmenopausal status, defined as one of the following:
• • Age ≥ 60 years
• • Age \< 60 with intact uterus and amenorrhea for 12 consecutive months or more
• • Status post bilateral oophorectomy, total hysterectomy
• • Ability to understand and willingness to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable), and willing and able to comply with scheduled visits and treatment schedule.
• Exclusion Criteria:
• • Inflammatory breast cancer (cT4d disease as per AJCC 8th edition).
• • Locally recurrent or metastatic disease (cM1 disease as per AJCC 8th edition).
• • Bilateral breast cancer.
• • Prior systemic therapy for the indexed breast cancer.
• • Pre-existing Grade ≥2 neuropathy.
• • Uncontrolled intercurrent illness that would limit compliance with study requirements.
• * A history of other malignancy ≤5 years prior to the indexed breast cancer diagnosis with the following exceptions:
• • Basal cell or squamous cell carcinoma of the skin which were treated with local resection only
• • Adequately treated carcinoma in situ of the cervix.
• • Prior or concurrent malignancy whose natural history or treatment will not interfere with the safety or efficacy assessments of the indexed breast cancer. In this event, review and approval by the study PI is required.
• • Concurrent participation in any investigational therapeutic trial for treatment of breast cancer.
• • Known HIV positivity that in the judgement of the treating physician would impact safety of chemotherapy receipt.
• • A history of allergic reactions attributed to compounds of similar chemical or biologic composition to anastrozole, taxanes (paclitaxel or nab-paclitaxel), anthracyclines (doxorubicin or epirubicin) or cyclophosphamide.
• • Evidence of uncontrolled ongoing or active infection, requiring parenteral anti-bacterial, anti-viral, or anti-fungal therapy ≤ 7 days prior to administration of study treatment. Patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible.
• • Any uncontrolled medical condition that in the opinion of the Investigator would pose a risk to participant safety or interfere with study participation or interpretation of individual participant results.